Methotrexate News and Research

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Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
Abbott opens biotech facility in Puerto Rico

Abbott opens biotech facility in Puerto Rico

Using a light hand to treat Hodgkin disease

Using a light hand to treat Hodgkin disease

New method of predicting rheumatoid arthritis offers early help to sufferers

New method of predicting rheumatoid arthritis offers early help to sufferers

A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis

A prediction rule for disease outcome in patients with recent-onset undifferentiated arthritis

Scientists find surprising way of switching off a gene involved in cell division

Scientists find surprising way of switching off a gene involved in cell division

Many Australian physicians not applying for permission to import Mifepristone

Many Australian physicians not applying for permission to import Mifepristone

Tumor necrosis factor A antagonist use and cancer in patients with rheumatoid arthritis

Tumor necrosis factor A antagonist use and cancer in patients with rheumatoid arthritis

Remicade receives European approval for treatment of psoriatic arthritis

Remicade receives European approval for treatment of psoriatic arthritis

NICE backs use of Enbrel and Raptiva to treat severe psoriasis

NICE backs use of Enbrel and Raptiva to treat severe psoriasis

Rituximab shown to significantly inhibit structural damage of joints caused by rheumatoid arthritis

Rituximab shown to significantly inhibit structural damage of joints caused by rheumatoid arthritis

The efficacy and safety of Rituximab in patients with active rheumatoid arthritis

The efficacy and safety of Rituximab in patients with active rheumatoid arthritis

Remicade (infliximab) gains Australian approval for treatment of early rheumatoid arthritis

Remicade (infliximab) gains Australian approval for treatment of early rheumatoid arthritis

FDA approves Rituxan (Rituximab)

FDA approves Rituxan (Rituximab)

Methotrexate re-use in rheumatoid arthritis is frequently effective despite earlier failures

Methotrexate re-use in rheumatoid arthritis is frequently effective despite earlier failures

Study associates chronic, severe inflammation with increased lymphoma risk among RA patients

Study associates chronic, severe inflammation with increased lymphoma risk among RA patients

Evidence supports combination therapy for achieving remission of early rheumatoid arthritis

Evidence supports combination therapy for achieving remission of early rheumatoid arthritis

Researchers identify genes affected by Methotrexate (MTX)

Researchers identify genes affected by Methotrexate (MTX)

Warning labels on high-risk drugs ignored by doctors

Warning labels on high-risk drugs ignored by doctors

Long-term benefits of initial combination therapy for rheumatoid arthritis

Long-term benefits of initial combination therapy for rheumatoid arthritis

Potential oral drug for rheumatoid arthritis

Potential oral drug for rheumatoid arthritis