Methotrexate News and Research

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Methotrexate is an antimetabolite and antifolate agent with antineoplastic and immunosuppressant activities. Methotrexate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses. Methotrexate also exhibits potent immunosuppressant activity although the mechanism(s) of actions is unclear.

Methotrexate is approved by the Food and Drug Administration (FDA) to be used by itself to treat the following types of gestational trophoblastic tumors, Chorioadenoma destruens, Choriocarcinoma, Hydatidiform mole. Methotrexate is also approved to be used alone or with other drugs to treat acute lymphoblastic leukemia (ALL) that has spread to the central nervous system (CNS) or to keep it from spreading there, and to treat the following, breast cancer, certain types of head and neck cancer, lung cancer, advanced non-Hodgkin lymphoma (NHL), advanced mycosis fungoides (a type of cutaneous T-cell lymphoma), osteosarcoma that has not spread to other parts of the body, following surgery to remove the primary tumor. Methotrexate is also approved to treat the following non-cancer conditions, rheumatoid arthritis, severe psoriasis.
Warning labels on high-risk drugs ignored by doctors

Warning labels on high-risk drugs ignored by doctors

Long-term benefits of initial combination therapy for rheumatoid arthritis

Long-term benefits of initial combination therapy for rheumatoid arthritis

Potential oral drug for rheumatoid arthritis

Potential oral drug for rheumatoid arthritis

Children who survive cancer face educational difficulties and social isolation

Children who survive cancer face educational difficulties and social isolation

Is the disease course of rheumatoid arthritis becoming milder?

Is the disease course of rheumatoid arthritis becoming milder?

Disease modifying activity of 2ME2 demonstrated in preclinical rheumatoid arthritis studies

Disease modifying activity of 2ME2 demonstrated in preclinical rheumatoid arthritis studies

Patients with primary biliary cirrhosis who are treated with methotrexate have an increased risk of death

Patients with primary biliary cirrhosis who are treated with methotrexate have an increased risk of death

Adalimumab and methotrexate is about five times more effective than methotrexate alone for rheumatoid arthritis

Adalimumab and methotrexate is about five times more effective than methotrexate alone for rheumatoid arthritis

Abbott receives European approval to market Humira

Abbott receives European approval to market Humira

Nanotechnology used to smuggle a powerful chemotherapeutic drug inside tumor cells

Nanotechnology used to smuggle a powerful chemotherapeutic drug inside tumor cells

MabThera highly effective in treating rheumatoid arthritis

MabThera highly effective in treating rheumatoid arthritis

Arthritis medications (methotrexate and leflunomide) commonly used in adults are safe and effective in children

Arthritis medications (methotrexate and leflunomide) commonly used in adults are safe and effective in children

Experts call for improved access to treatment for psoriatic arthritis

Experts call for improved access to treatment for psoriatic arthritis

Brewing up potential anti-cancer drugs from green tea

Brewing up potential anti-cancer drugs from green tea

Trial of Etanercept for Wegners's disease shows no benefit against the autoimmune condition

Trial of Etanercept for Wegners's disease shows no benefit against the autoimmune condition

RU-486 plus prostaglandins remains the most effective nonsurgical abortion method

RU-486 plus prostaglandins remains the most effective nonsurgical abortion method

Promising new evidence for the optimal use of biologic therapies for rheumatoid arthritis

Promising new evidence for the optimal use of biologic therapies for rheumatoid arthritis

FDA accepts Genmab's Investigational New Drug Application for active rheumatoid arthritis treatment

FDA accepts Genmab's Investigational New Drug Application for active rheumatoid arthritis treatment

Researchers step closer to cure for common childhood cancer

Researchers step closer to cure for common childhood cancer

Remicade (infliximab) is able to reverse the symptoms of rheumatoid arthritis

Remicade (infliximab) is able to reverse the symptoms of rheumatoid arthritis