Microarray News and Research

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Decreased breast cancer survival associated with high TRAIL-R2 expression

High expression of TRAIL-R2, a cell surface receptor that triggers cell death, has been shown to be associated with a decrease the survival rates of breast cancer patients according to a study published by Yale Cancer Center researchers in Clinical Cancer Research.

25 Jul 2005

Protein found in fat cells is a newly discovered cause of insulin resistance

A study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) has shown that a protein found in fat cells is a newly discovered cause of insulin resistance, establishing a previously unidentified molecular link between obesity and type 2 diabetes and offering a potential new target for the development of drugs to treat diabetes.

20 Jul 2005

Functional analysis of human hematopoietic stem cell gene expression using zebrafish

What do you get when you mix RNA chips and zebrafish? A new two-stage method for studying human gene expression differs in human stem cells and progenitor cells, according to a new article in the open access journal PLoS Biology.

6 Jul 2005

Scientists discover identifying markers for primitive blood-forming stem cells - simplifies cell identification

Scientists at the University of Michigan Medical School have discovered the biological equivalent of a grocery store bar code on the surface of primitive, blood-forming stem cells in mice. Called hematopoietic stem cells, they give rise to all the different types of specialized cells found in blood.

30 Jun 2005

Map of gene control regions provides tool for understanding cells' different roles

In another step to decipher information in the human genome, scientists have discovered the location and sequence of over 10,000 DNA regions that function as genetic on-off switches, or "promoters" in human fibroblasts.

29 Jun 2005

New clues about the location of genes potentially involved in the most common type of lung cancer

Using technology that makes it possible to zoom in on smaller sections of cell chromosomes than ever before, researchers at Dana-Farber Cancer Institute have identified nearly 100 chromosome regions where genes are either over-copied or missing in non-small cell lung cancer.

27 Jun 2005

New techniques use mitochondrial DNA as an early indicator for certain types of cancer

A pilot study at the National Institute of Standards and Technology (NIST), in support of the National Cancer Institute's Early Detection Research Network (EDRN), has validated the measurement accuracy of new techniques that use mitochondrial DNA as an early indicator for certain types of cancer.

16 Jun 2005

New study shows tiny RNAs intimately associated with cancer

In discoveries that may open a new chapter in understanding and diagnosing cancer, Howard Hughes Medical Institute (HHMI) investigators and their colleagues have established that tiny microRNAs provide a novel genetic route to the initiation of some forms of cancer.

9 Jun 2005

New device has the potential to significantly reduce sequencing of the human genome

The sequencing of the human genome was only the beginning of a much more complex task – deciphering the secrets of cellular chemistry and the mechanisms of disease. While the genome serves as a blueprint to understanding the body, proteins represent the materials that carry out these plans.

8 Jun 2005

Technology for analyzing gene expression must be standardized

Technology for analyzing gene expression must be standardized among laboratories and across platforms around the world to support this age of human genome exploration, an Oregon Health & Science University researcher says.

29 May 2005

Neutrophils dictate whether our immune system will permit or prevent bacterial infections

New research on a bacterium that can survive encounters with specific immune system cells has strengthened scientists' belief that these plentiful white blood cells, known as neutrophils, dictate whether our immune system will permit or prevent bacterial infections.

5 May 2005

Specific genes play key role in the of regulation of human-blood stem cells

This work is the first to validate gene expression analysis in human stem cells with functional experiments. The findings also suggest that changes in the expression of genes associated with universal cell signaling pathways can have a substantial impact on human stem cell behavior.

2 May 2005

Small number of genes can predict response to chronic hepatitis C therapy

For the first time, physicians at University Health Network and University of Toronto have identified a small subset of genes that can predict whether a patient with chronic Hepatitis C will be able to respond to current treatments.

2 May 2005

P12 protein influences key cell-signaling pathway

New research shows that a protein produced by a cancer-causing virus influences a key signaling pathway in the immune cells that the virus infects. This stimulates the cells to divide, helping the virus spread through the body.

26 Apr 2005

One step closer to personalized medical treatment

A new study by 64 renowned scientists may bring us one step closer to personalized medical treatment--that is, medical treatment tailored to each person's unique genetic make-up and medical condition.

22 Apr 2005

New strategy to identify differences between non-metastatic and highly metastatic breast cancer cells

Researchers at the University of California, San Diego have used a new strategy to identify differences between non-metastatic and highly metastatic breast cancer cells. The article by Valerie Montel et al., "Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model," appears in the May 2005 issue of The American Journal of Pathology and is accompanied by a commentary.

22 Apr 2005

Assessing the function of unknown genes is feasible and can be done with a microarray phenotype

Microarrays provide a method of quantifying the expression and order of genes in a particular genome -- acting as a surrogate measure of cell physiology, said researchers at Baylor College of Medicine in a report that appears online today in the journal Nature Genetics.

10 Apr 2005

SERPINE2 identified as novel candidate gene for COPD susceptibility

Using a combination of genetic linkage, microarray gene expression and genetic association studies, a group of Brigham and Women’s Hospital/ Harvard Medical School researchers have identified a serine protease inhibitor clade E, member 2, or SERPINE2, “as a novel candidate susceptibility gene for COPD,” according to Sorachai Srisuma

3 Apr 2005

ParAllele BioScience announces key patent issuance

ParAllele BioScience has announced the issuance by the U.S. Patent Office of a key patent (6,858,412) covering its Molecular Inversion Probe (MIP) technology. The patent is owned by Stanford University and is exclusively licensed to ParAllele.

21 Mar 2005

Genomic analysis may one day be a primary diagnostic tool for physicians deciding on a course of treatment for trauma

The researchers showed that state-of-the-art techniques for rapidly analyzing changes in activity of all human genes will likely produce useful insights into the health of critically ill patients. The findings, which are available online and will be published in the March 29 issue of the Proceedings of the National Academy of Sciences, make it possible for physicians to begin answering important questions about critical care through genomic analysis.