Microfluidics News and Research

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DNA-encoded antibody libraries

During the past several years, breakthroughs in genomic and proteomic technologies have enabled researchers to more clearly identify the biochemical networks that malfunction when a healthy cell becomes malignant.

12 Feb 2007

Microfluidics gives boost to protein crystallization

Proteins produced by cancer cells are among the common targets for anticancer agents, and thanks to efforts in proteomics and cancer genomics, the number of potential protein targets is increasing exponentially.

16 Jan 2007

A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability

In an accomplishment that represents a significant step toward an era of rapid, inexpensive, bedside testing for cancer, researchers at the University of Virginia have developed a microfluidic device that can process human blood samples and yield diagnostic results within an hour.

8 Jan 2007

Nonlithographic fabrication of microfluidic devices

Typically, researchers create microfluidic devices using the same lithographic techniques and tools used to fabricate computer chips. Lithography is expensive and slow, factors that could limit the ultimate utility of microfluidic devices in clinical applications.

4 Dec 2006

Low-field magnetic separation of monodisperse Fe3O4 nanocrystals

Whether the goal is to separate different types of cells or molecules, methods that rely on the age-old principle of magnetism are a staple among researchers.

20 Nov 2006

Watching a tumor cell migrate

Using a microfluidics device designed to reproduce the physical microenvironment of small blood vessels and the spaces between cells, researchers at the National University of Singapore have imaged single tumor cells deforming as they migrate through the device.

20 Nov 2006

A nanoplasmonic molecular ruler for measuring nuclease activity and DNA footprinting

The interactions between proteins and nucleic acids play a critical role in some of life’s most crucial biochemical processes, including gene expression and protein production, and some promising anticancer agents exert their effects by interfering with these interactions.

16 Oct 2006

Lab-on-a-chip technology for determination of protein isoform profiles

A new microfluidics device that uses immobilized antibodies and carbon nanostrings as detection agents can identify slight variations in protein composition, known as protein isoforms, that could indicate the presence of cancer.

16 Oct 2006

Simultaneous synthesis and screening in a microfluidics device

In the quest for new methods to synthesize large numbers of drug leads, medicinal chemists are increasingly turning to microfluidics as a means of performing dozens of chemical reactions using minute quantities of chemical reagents.

From Siemens Healthineers 2 Oct 2006

Electrochemical fabrication of conducting polymer nanowires in an integrated microfluidic system

There seems to be little doubt among cancer researchers that new detection systems using nanowires and microfluidics hold the promise of providing a quantum leap in the detection of cancer-related molecules and genes.

25 Sep 2006

Nanocantilever biosensors detect multiple genes

Using nanoscale cantilevers in a microfluidics device, a team of European researchers has developed a portable biosensor capable of detecting specific genetic sequences.

19 Sep 2006

Detecting cancer with silica nanoparticles

Tumor necrosis factor-alpha is a widely accepted biomarker for cancer, but the minute amounts of this protein circulating in blood makes detecting the molecule and measuring its concentration accurately a technological challenge.

19 Sep 2006

Cell detachment model for an antibody-based microfluidic cancer screening system

In the quest to detect more types of cancers at ever earlier stages, researchers have been stymied by a lack of cell surface markers that distinguish in a clear-cut manner between healthy and malignant cells.

19 Sep 2006

New microfluidic device suitable for large-scale screening of disease-related biomarkers

Researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech have developed a disposable microchip that replaces space-consuming instrumentation with fast, cost-effective, lab-on-a-chip technology.

5 Sep 2006

Digital magnetofluidics holds hope for better medicine

Critical advances in medicine and environmental protection promise to emerge from a new method for biochemical analysis of fluids developed by an international science team led in part by Arizona State University researchers.

21 Jul 2006

Magnetic nanotechnology holds promise in fighting cancer

Detecting cancer and reinventing computing are two challenges that seemingly have little, if anything, to do with each other. That is, unless you are a nanotechnologist like Shan Wang, an associate professor of materials science and engineering and of electrical engineering at Stanford.

20 Apr 2006

Breakthrough in fast, disposable DNA testing

Thermal Gradient announced today that it has successfully developed a 30-cycle PCR device that can amplify DNA in just 4.4 minutes, far faster than anything available in the marketplace.

9 Mar 2006

New technology could replace time-intensive urine specimens

For the millions of people who suffer from urinary tract infections each year and the doctors who treat them, a promising new biosensor technology has been developed that may replace antiquated testing methods and save precious health care dollars.

12 Feb 2006

New DNA-based cell adhesion strategy

A new technique in which single strands of synthetic DNA are used to firmly fasten biological cells to non-biological surfaces has been developed by researchers with the Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California at Berkeley.

9 Feb 2006

Lab-on-chip can detect bird flu in humans

European microchip maker STMicroelectronics is planning to market a disposable laboratory microchip that can confirm within about an hour a human case of bird flu.

18 Jan 2006