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Autism in males may result from problems in brain-based immune cells

Many cases of autism spectrum disorders may result from problems in immune cells that normally work to trim back unneeded brain connections in early life, suggests a new study led by scientists at Scripps Research.

15 Apr 2020

Toxic cell atlas can guide discovery of new drugs for neurodegeneration

A common thread in many inflammatory and neurodegenerative diseases, including multiple sclerosis (MS), is damage caused by oxidative stress. Oxidative stress occurs when cells produce toxic substances known as reactive oxygen species, which are damaging nerve cells and other cells in the body.

13 Apr 2020

Large-scale proteomic analysis links glucose metabolism proteins and AD biology

In the largest study to date of proteins related to Alzheimer's disease, a team of researchers has identified disease-specific proteins and biological processes that could be developed into both new treatment targets and fluid biomarkers.

13 Apr 2020

Large-scale analysis links glucose metabolism proteins to Alzheimer's disease biology

A team has identified Alzheimer's disease-specific proteins and processes that could be used for treatment targets and biomarkers.

13 Apr 2020

Alzheimer's disease: high amyloid levels linked to early disease

A new study published in the journal JAMA Neurology in April 2020 seems to indicate that higher brain amyloid levels represent early Alzheimer's disease (AD).

6 Apr 2020

Study shows how Toxoplasma infection causes seizures, psychiatric illness for some

Think about traffic flow in a city - there are stop signs, one-way streets, and traffic lights to organize movement across a widespread network. Now, imagine what would happen if you removed some of the traffic signals.

2 Apr 2020

Gene that could affect the progress of ALS discovered

Researchers from the Zuckerman Institute at Columbia University have successfully found a gene that could work towards accelerating the progression of ALS or amyotrophic lateral sclerosis. The study titled, "The loss of TBK1 kinase activity in motor neurons or in all cell types differentially impacts ALS disease progression in SOD1 mice," was published in the latest issue of the journal Neuron.

29 Mar 2020

Newly developed laboratory model helps reveal how HIV infection affects the brain

Though many negative repercussions of human immunodeficiency virus infection can be mitigated with the use of antiretroviral therapy, one area where medical advances haven't made as much progress is in the reduction of cognitive impacts.

27 Mar 2020

Immune mechanism in the brain appears to play key role in the development of Alzheimer's

An immune reaction in the brain seems to play a major role in the development of Alzheimer's disease. In a way, it "adds fuel to the fire" and apparently causes an inflammation that, in a sense, keeps kindling itself. The study has now been published in the journal Cell Reports.

18 Mar 2020

Novel Alzheimer's risk genes affect microglial response to amyloid-beta

Our DNA determines a large part of our risk for Alzheimer's disease, but it remained unclear how many genetic risk factors contribute to disease.

18 Mar 2020

New approach to stimulate immune cells may provide better protection against Alzheimer's

Scientists at the German Center for Neurodegenerative Diseases, the Ludwig-Maximilians-Universitaet Munich and Denali Therapeutics (South San Francisco, CA, USA) have developed an approach to stimulate immune cells of the brain in such a way that they might possibly provide better protection against Alzheimer's disease.

10 Mar 2020

Stress-linked disorders increase the risk of later brain degeneration

A new study published in the journal JAMA Neurology in March 2020 suggests that stress-related disorders increase the risk of later development of dementia and other neurodegenerative disorders.

9 Mar 2020

UQ study identifies a major shift in how to treat brain injuries

Researchers have identified a major shift in how to treat brain injuries, after rejuvenating immune cells to support the repair process.

9 Mar 2020

Researchers find link between interferon, neuroinflammation and synapse loss in Alzheimer's

When immunologist Dr. Wei Cao joined Baylor College of Medicine three-and-a-half years ago, her first project was to investigate how inflammation contributes to Alzheimer's disease.

5 Mar 2020

Visceral fat gives signal to the brain that damages cognition

Excessive weight around our middle gives our brain's resident immune cells heavy exposure to a signal that turns them against us, setting in motion a crescendo of inflammation that damages cognition, scientists say.

3 Mar 2020

A protein critical for wound healing and neural repair following spinal cord injury identified

Plexin-B2, an axon guidance protein in the central nervous system (CNS), plays an important role in wound healing and neural repair following spinal cord injury (SCI), according to research conducted at the Icahn School of Medicine at Mount Sinai and published today in Nature Neuroscience. T

2 Mar 2020

Microglia play a dual role in regulating the permeability of blood-brain barrier, study shows

The blood-brain barrier is a layer of cells that covers the blood vessels in the brain and regulates the entry of molecules from the blood into the brain.

28 Feb 2020

Targeting overactive immune cells with experimental drug could improve TBI symptoms

Researchers at the University of Maryland School of Medicine found that targeting overactive immune cells in the brain with an experimental drug could limit brain cell loss and reverse cognitive and motor difficulties caused by traumatic brain injury.

25 Feb 2020

Supplementing diet with amino acid delays signs of ALS in animal study

The addition of dietary L-serine, a naturally occurring amino acid necessary for formation of proteins and nerve cells, delayed signs of amyotrophic lateral sclerosis in an animal study.

24 Feb 2020

Dampening effects of overactive immune cells may serve as new treatment for TBI

Targeting overactive immune cells and dampening their effects may serve as a new treatment for treating a traumatic brain injury, according to new research in mice published in JNeurosci.

From Society for Neuroscience 19 Feb 2020

Microglia News and Research

Autism in males may result from problems in brain-based immune cells

Toxic cell atlas can guide discovery of new drugs for neurodegeneration

Large-scale proteomic analysis links glucose metabolism proteins and AD biology

Large-scale analysis links glucose metabolism proteins to Alzheimer's disease biology

Alzheimer's disease: high amyloid levels linked to early disease

Study shows how Toxoplasma infection causes seizures, psychiatric illness for some

Gene that could affect the progress of ALS discovered

Newly developed laboratory model helps reveal how HIV infection affects the brain

Immune mechanism in the brain appears to play key role in the development of Alzheimer's

Novel Alzheimer's risk genes affect microglial response to amyloid-beta

New approach to stimulate immune cells may provide better protection against Alzheimer's

Stress-linked disorders increase the risk of later brain degeneration

UQ study identifies a major shift in how to treat brain injuries

Researchers find link between interferon, neuroinflammation and synapse loss in Alzheimer's

Visceral fat gives signal to the brain that damages cognition

A protein critical for wound healing and neural repair following spinal cord injury identified

Microglia play a dual role in regulating the permeability of blood-brain barrier, study shows

Targeting overactive immune cells with experimental drug could improve TBI symptoms

Supplementing diet with amino acid delays signs of ALS in animal study

Dampening effects of overactive immune cells may serve as new treatment for TBI

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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