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Inhibiting cholesterol esterification can potentiate antitumor activity of killer T cells

As key players in the immune system, T cells provide tumor surveillance and have direct antitumor effects. However, tumors can escape T-cell attack through various mechanisms in the tumor microenvironment. Reactivating the antitumor effects of T cells has shown great clinical benefits in treating various cancers.

18 Mar 2016

Scientists find evidence that amyloid fibrils adopt several distinct architectures in human, animal tissues

Formation of amyloid fibrils is a characteristic feature of neurogenerative diseases like Alzheimer's. As published in the journal Angewandte Chemie, German and American scientists have found evidence that these fibrils adopt several distinct three-dimensional architectures in real patient and animal tissues.

16 Mar 2016

Could prebiotics benefit early life brain development? An interview with Dr Phil Burnet

Galacto-oligosaccharides are essentially sugar or saccharide molecules that have been joined together into short polymer chains.

16 Mar 2016

Smartphone microscopes could improve detection of skin cancer in developing countries

Everyone knows smartphones can be used as calendars, calculators, radios and cameras. But, did you know they can also be used as microscopes that have the potential to save lives? They are called smartphone microscopes and dermatologists at The University of Texas Health Science Center at Houston think these devices could improve the detection of skin cancer in developing countries.

16 Mar 2016

NIH-funded investigators develop therapeutic compound effective against malaria

An international team that includes NIH-funded researchers at Stanford University has developed a therapeutic compound that is effective in inhibiting Plasmodium falciparum, one of five species of parasite that infects people with malaria, and the strain which causes the highest number of malaria deaths.

13 Mar 2016

Novel nanoparticle technology can decipher protein structures and help access drug targets

Researchers at Karolinska Institutet, Sweden, have developed a nanoparticle technology that can be used to stabilise membrane proteins so that their structure can be studied in a lipid environment. The method, described in Nature Methods, makes it possible to access drug targets that previously could not be investigated and therefore potentially allows for the development of novel drugs, therapeutic antibodies and vaccines.

9 Mar 2016

Pittcon 2016: Bruker showcases new products and analytical solutions

This week at Pittcon 2016, Bruker is showcasing new products and analytical solutions for core Applied & Pharma markets, for our Nanoanalysis, Microscopy & Advanced Materials Research markets, as well as new after-market services and life-cycle support solutions for our customers.

From Bruker BioSpin - NMR, EPR and Imaging 8 Mar 2016

UC Berkeley study provides compelling evidence in favor of 'active learning'

Scientists at the University of California, Berkeley, have captured unique images of problem-solving in action by tapping into the minds of mice. The study shows rapid rewiring in the frontal brains of mice after they learn by trial and error.

8 Mar 2016

New study sheds light on challenges in addressing post-operative bleeding in newborns

A new study finds significant differences between the blood clot structure in adults and newborns, helping researchers better understand the challenges in addressing post-operative bleeding in neonatal patients.

7 Mar 2016

Researchers solve structure of key protein in coronaviruses, like MERS and SARS

When the respiratory illness SARS (Severe Acute Respiratory Syndrome) emerged in 2003, it killed at least 775 people before it was contained. Nine years later, MERS (Middle East Respiratory Syndrome) began circulating in the human population—and has gone on to have a 36 percent case fatality rate.

7 Mar 2016

Expression of BIRC3 protein associated with poor survival, recurrent disease in GBM patients

Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with low survival rates, with newly diagnosed patients surviving a median of 14 months and recurrent patients surviving a median of only 3 to 9 months. New therapeutic targets and biomarkers for prognosis are urgently needed.

7 Mar 2016

On-demand liquid nitrogen generator

The Asynt CryoSyn is a unique on-demand generator (available in 10, 20, 40, 60 & 120L capacity models) which generates liquid nitrogen and nitrogen gas for industrial, medical, food and agricultural, biological and general laboratory applications.

From Asynt 29 Feb 2016

Cryo-electron microscopy helps analyze infection mechanisms of coronaviruses in detail

High-resolution cryo-electron microscopy and supercomputing have now made it possible to analyze in detail the infection mechanisms of coronaviruses. These viruses are notorious for attacking the respiratory tract of humans and animals.

27 Feb 2016

Researchers develop effective technique for studying high-arched palate using mouse model

Researchers from the laboratory of Paul Trainor, Ph.D., at the Stowers Institute of Medical Research have developed an effective and reliable technique for studying high-arched palate using a mouse model. The methodology could expand research into the genetic aspects of this craniofacial abnormality.

27 Feb 2016

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Life-threatening heart damage is an adverse side effect of the cancer drug doxorubicin, damage that also limits the use of newer chemotherapeutic agents such as trastuzumab and imatinib. The ability to protect the heart from these side effects would benefit patients, including cancer survivors who are at risk of developing heart damage years later, and it also could allow safer use of these drugs at higher doses.

26 Feb 2016

Moffitt researchers develop novel therapeutic strategy to keep resistant cells in check

Despite numerous advances in oncology since the War on Cancer began, many patients develop resistance to standard therapies and eventually relapse. Moffitt Cancer Center researchers hope to improve treatment outcomes with development of a novel therapeutic strategy, called adaptive therapy, which is based on evolutionary principals and aims to keep resistant cells in check by maintaining a population of chemo-sensitive cells.

25 Feb 2016

Study provides pathways to understand complex neurological disorders

Scientists have now described the engineering of a bright red fluorescent protein-based voltage indicator, providing pathways to understanding complex neurological disorders. Designated as FlicR1 (fluorescent indicator for voltage imaging red), these indicators enable imaging of the electrical activity of many genetically targeted neurons with high spatial and temporal resolution.

25 Feb 2016

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase.

25 Feb 2016

MR Solutions introduces new 3D in vivo confocal microscope for preclinical research

MR Solutions’ new 3D in vivo confocal microscope for use in preclinical research provides a magnification range of up to 1000 times, allowing researchers to examine cellular details within a live small animal eliminating the need for a surgical biopsy - saving time and substantially reducing costs.

From MR Solutions 24 Feb 2016

UAB researchers use Malvern’s NanoSight NS300 system to figure out role of exosomes in disease transmission

Data measured using the NanoSight NS300 from Malvern Instruments is providing new insights into the role of exosomes in diseases such as cancer, arthritis, Alzheimer’s disease and cystic fibrosis, in pioneering research at the University of Alabama - Birmingham (UAB).

23 Feb 2016

Microscopy News and Research

Inhibiting cholesterol esterification can potentiate antitumor activity of killer T cells

Scientists find evidence that amyloid fibrils adopt several distinct architectures in human, animal tissues

Could prebiotics benefit early life brain development? An interview with Dr Phil Burnet

Smartphone microscopes could improve detection of skin cancer in developing countries

NIH-funded investigators develop therapeutic compound effective against malaria

Novel nanoparticle technology can decipher protein structures and help access drug targets

Pittcon 2016: Bruker showcases new products and analytical solutions

UC Berkeley study provides compelling evidence in favor of 'active learning'

New study sheds light on challenges in addressing post-operative bleeding in newborns

Researchers solve structure of key protein in coronaviruses, like MERS and SARS

Expression of BIRC3 protein associated with poor survival, recurrent disease in GBM patients

On-demand liquid nitrogen generator

Cryo-electron microscopy helps analyze infection mechanisms of coronaviruses in detail

Researchers develop effective technique for studying high-arched palate using mouse model

Over-expression of heme oxygenase-1 enzyme protects the heart from doxorubicin damage

Moffitt researchers develop novel therapeutic strategy to keep resistant cells in check

Study provides pathways to understand complex neurological disorders

Researchers reveal how stress conditions favor lytic reactivation of herpesviruses

MR Solutions introduces new 3D in vivo confocal microscope for preclinical research

UAB researchers use Malvern’s NanoSight NS300 system to figure out role of exosomes in disease transmission

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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