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Signaling pathway in fat cells may provide key to better treatments for obesity, Penn research finds

A signaling pathway in fat cells may one day provide the key to better treatments for obesity, according to new research by scientists in the Perelman School of Medicine at the University of Pennsylvania.

6 Dec 2016

Research unlocks potential new therapies for inflammatory diseases

Macrophages are frontline cells in our immune system. They detect microbial invaders and also tissue injury and then mount an appropriate response needed to clear the infection and repair the damaged tissue.

5 Dec 2016

Biomedical scientist develops new way to create micro muscles for testing muscle efficiency

A biomedical research scientist is taking the lead in the creation of muscle cells and micro muscles to test muscle efficiency in the laboratory - and he is able to carry out this new and innovative work thanks to the support he has received to get him back into science after a career break.

30 Nov 2016

Allen Institute for Cell Science releases gene edited, fluorescently tagged human iPS cells

The Allen Institute for Cell Science has released the Allen Cell Collection: the first publicly available collection of gene edited, fluorescently tagged human induced pluripotent stem cells that target key cellular structures with unprecedented clarity.

30 Nov 2016

Targeting metabolic function of breast cancer may help combat disease

How does a cancer cell burn calories? New research from Thomas Jefferson University shows that breast cancer cells rely on a different process for turning fuel into energy than normal cells.

28 Nov 2016

BAG3 protein plays protective role by limiting reperfusion injury to the heart

The inability of cells to eliminate damaged proteins and organelles following the blockage of a coronary artery and its subsequent re-opening with angioplasty or medications - a sequence known as ischemia/reperfusion - often results in irreparable damage to the heart muscle.

17 Nov 2016

Discovery of novel protein could lead to potential new treatments for age-related retinal disease

The discovery of a novel protein that links aging and age-dependent retinal diseases could lead to potential new treatments for conditions that cause sight loss in later life.

15 Nov 2016

Cannabinoid receptors regulate memory processes by modulating mitochondrial energy metabolism

It has been known for some time that the extracts of the Cannabis plant, just like synthetic cannabinoids and those produced by the brain itself, join up with type 1 (CB1) cannabinoid receptors located in the nerve endings of the neurons, and inhibit the release of chemical messengers (neurotransmitters) in the communication areas between the nerve cells.

10 Nov 2016

Scientists show how key protein can be important driver of prostate cancer

Scientists at The Wistar Institute have demonstrated how a protein called TRAP1 - an important regulator of energy production in healthy and cancerous cells - is an important driver of prostate cancer and appears to be a valuable therapeutic target for the disease.

9 Nov 2016

Collapse of MAM is common pathological hallmark to certain inherited forms of ALS

Amyotrophic lateral sclerosis (ALS) is an adult onset, fetal neurodegenerative disease that selectively affects motor neurons.

8 Nov 2016

Scientists investigate role of mitochondria in Alzheimer's disease pathology

On Nov. 25, 1901, a 51-year-old woman is admitted to a hospital in Frankfurt, Germany, displaying a bizarre constellation of symptoms.

8 Nov 2016

Stanford researchers discover new biological markers to measure progression of Huntington's disease

Researchers at Stanford University School of Medicine have identified several new biological markers to measure the progression of the inherited neurodegenerative disorder Huntington's disease (HD).

7 Nov 2016

Genetic mutation confers risk for development of Parkinson's disease earlier than usual

A collaboration of 32 researchers in seven countries, led by scientists at Mayo Clinic's campus in Florida, has found a genetic mutation they say confers a risk for development of Parkinson's disease earlier than usual.

3 Nov 2016

Structure and number of mitochondria may help determine muscle endurance, research shows

We can all recognise that feeling of muscle fatigue after taking a brisk walk, cycling, running or playing football.

2 Nov 2016

New study shows final stages of how mitochondria regularly divide and propagate

A new University of Colorado Boulder study shows for the first time the final stages of how mitochondria, the sausage-shaped, power-generating organelles found in nearly all living cells, regularly divide and propagate.

2 Nov 2016

Research shows genetic link between mitochondrial DNA and autism

Cornell University researchers have confirmed a genetic link between mitochondrial DNA (mtDNA), which is passed on from the mother, and some forms of autism spectrum disorder (ASD).

31 Oct 2016

Natural compound slows typical signs of aging in mice

Much of human health hinges on how well the body manufactures and uses energy. For reasons that remain unclear, cells' ability to produce energy declines with age, prompting scientists to suspect that the steady loss of efficiency in the body's energy supply chain is a key driver of the aging process.

27 Oct 2016