Mitochondria News and Research

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Researchers explore changes in Parkinson's-affected cells at different stages of the disease

It's an unsettling thought: You could be walking around for 20 years developing Parkinson's disease and not even know it.

29 Apr 2016

Rapamycin drug could target neural damage linked to Leigh syndrome

Salk Institute scientists showed how an FDA-approved drug boosts the health of brain cells by limiting their energy use. Like removing unnecessary lighting from a financially strapped household to save on electricity bills, the drug--called rapamycin--prolongs the survival of diseased neurons by forcing them to reduce protein production to conserve cellular energy.

27 Apr 2016

Microtubules affect mechanics of beating heart, study finds

On top of the meaning and mystery that humans heap on the heart, it is first and foremost, a muscle. And one that beats about once a second for a person's entire life, with no rest. Given its vital importance, it's ironic researchers have only recently made direct observations of its subcellular parts in motion.

22 Apr 2016

Oxidized mitochondrial nucleoids released from neutrophils may contribute to SLE pathogenesis

Researchers at the Baylor Institute for Immunology Research have discovered that the neutrophils of systemic lupus erythematosus (SLE) patients release oxidized DNA from their mitochondria that can stimulate an unwanted immune response.

19 Apr 2016

PITRM1 protein may be involved in development of Alzheimer's disease

University of Bergen researchers have found a protein that could hold the key to understanding how Alzheimer's disease develops.

14 Apr 2016

Six newly identified proteins may help potentially unlock new insights into aging-related diseases

A group of six newly discovered proteins may help to divulge secrets of how we age, potentially unlocking new insights into diabetes, Alzheimer's, cancer, and other aging-related diseases.

12 Apr 2016

Novel metabolic pathways help cancer cells thrive under certain conditions

Scientists at the Children's Medical Center Research Institute at UT Southwestern (CRI) have identified a novel metabolic pathway that helps cancer cells thrive in conditions that are lethal to normal cells.

7 Apr 2016

Tumor suppressor p53 gene twice as likely to be defective in autistic children

A large study by researchers with the UC Davis MIND Institute has found that a gene whose role is to suppress cellular damage from environmental stressors is nearly twice as likely to be defective in children with autism spectrum disorder (ASD), and that the deficit is also present in their fathers.

1 Apr 2016

High-intensity workout could do more harm than good

High-intensity 'sprint training' may be gaining popularity at gyms, but if you're new to this form of exercise, the workout could do more harm than good.

24 Mar 2016

Research shows how recreational ketamine abuse harms the bladder

Research conducted by scientists at the University of York has revealed how recreational ketamine abuse damages the bladder

21 Mar 2016

Manipulation of NAD could lead to potential therapy for acute kidney injury

Approximately one out of five hospitalized adults and one out of three hospitalized children worldwide experience acute kidney injury, the sudden loss of kidney function. Many different factors, including surgery, chemotherapy or shock, can lead to acute kidney injury, but exactly why the kidneys are so vulnerable to these and other stressors has not been well understood.

19 Mar 2016

Drugs to help energy-starved photoreceptors offers new avenue for treating AMD , MacTel

New research from Boston Children's Hospital could potentially change how doctors approach two blinding diseases: 'Wet' age-related macular degeneration (AMD), the leading cause of blindness in the elderly, and macular telangiectasia (MacTel).

15 Mar 2016

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Malfunctioning mitochondria — the power plants in cells — are behind the damage caused by strokes, heart attacks, and neurodegenerative diseases, but little has been known about how to stop these reactors from melting down, destroying cells and tissue. Mitochondria also take up calcium, which regulates energy production.

11 Mar 2016

Inhibition of mitochondrial calcium uptake specifically toxic to cancer cells

Inhibiting the transfer of calcium ions into the cell's powerhouse is specifically toxic to cancer cells, according to an article published this week in Cell Reports by researchers from the Perelman School of Medicine at the University of Pennsylvania.

4 Mar 2016

Researchers uncover new pathway for mitochondrial cell death

Researchers at St. Jude Children's Research Hospital have uncovered a new pathway for mitochondrial cell death that involves the protein BCL-2 ovarian killer, otherwise known as BOK. The discovery, which is described online in the journal Cell, may lead to new ways to trigger cell death in some types of cancer cells.

4 Mar 2016

Study provides critical insight into Warburg effect

PGK1, a glycolytic enzyme, has been found to play a role in coordinating cellular processes crucial to cancer metabolism and brain tumor formation, according to results published in today's online issue of Molecular Cell. The findings may lay the groundwork for improved approaches to diagnosis and treatment of glioblastoma and other cancers.

4 Mar 2016

Researchers reveal link between mitochondrial dysfunction and Fuchs' Endothelial Corneal Dystrophy

Researchers at Schepens Eye Research Institute of Massachusetts Eye and Ear have shown a link between mitochondrial dysfunction in corneal endothelial cells and the development of Fuchs' Endothelial Corneal Dystrophy.

4 Mar 2016

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

When the heart begins to fail, the body does everything in its power to fix the situation. But sometimes, those compensatory mechanisms ultimately do more harm than good. Such is the case with the adrenal hormone aldosterone, which stimulates the heart to pump harder, causing greater damage to the heart muscle.

3 Mar 2016

Novel mitochondria-specific ceria nanoparticles can effectively suppress neuronal cell death

The brain is an enormous network of communication, containing over 100 billion nerve cells, or neurons, with branches that connect at more than 100 trillion points. They are constantly sending signals through a vast neuron forest that forms memories, thoughts and feelings; these patterns of activity form the essence of each person.

27 Feb 2016

Protein p62 acts as molecular brake to keep inflammation in check, avoid collateral damage

Inflammation is a Catch-22: the body needs it to eliminate invasive organisms and foreign irritants, but excessive inflammation can harm healthy cells, contributing to aging and sometimes leading to organ failure and death. Researchers at University of California, San Diego School of Medicine have discovered that a protein known as p62 acts as a molecular brake to keep inflammation in check and avoid collateral damage.

26 Feb 2016

Mitochondria News and Research

Researchers explore changes in Parkinson's-affected cells at different stages of the disease

Rapamycin drug could target neural damage linked to Leigh syndrome

Microtubules affect mechanics of beating heart, study finds

Oxidized mitochondrial nucleoids released from neutrophils may contribute to SLE pathogenesis

PITRM1 protein may be involved in development of Alzheimer's disease

Six newly identified proteins may help potentially unlock new insights into aging-related diseases

Novel metabolic pathways help cancer cells thrive under certain conditions

Tumor suppressor p53 gene twice as likely to be defective in autistic children

High-intensity workout could do more harm than good

Research shows how recreational ketamine abuse harms the bladder

Manipulation of NAD could lead to potential therapy for acute kidney injury

Drugs to help energy-starved photoreceptors offers new avenue for treating AMD , MacTel

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Inhibition of mitochondrial calcium uptake specifically toxic to cancer cells

Researchers uncover new pathway for mitochondrial cell death

Study provides critical insight into Warburg effect

Researchers reveal link between mitochondrial dysfunction and Fuchs' Endothelial Corneal Dystrophy

Researchers discover unexpected mechanism linked to aldosterone-induced heart damage

Novel mitochondria-specific ceria nanoparticles can effectively suppress neuronal cell death

Protein p62 acts as molecular brake to keep inflammation in check, avoid collateral damage

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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