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New drug targets key mechanism in ALS, protects motor neurons

A new pharmacological inhibitor can intervene in a central cell death mechanism that is responsible for the death of motor neurons and hence important for the progression of the motor neuron disease amyotrophic lateral sclerosis (ALS).

8 Feb 2024

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "PROX1 interaction with α-SMA-rich cancer-associated fibroblasts facilitates colorectal cancer progression and correlates with poor clinical outcomes and therapeutic resistance."

8 Feb 2024

New treatment target found for CDKL5 deficiency disorder

Scientists at the Francis Crick Institute have found a new treatment target for CDKL5 deficiency disorder (CDD), one of the most common types of genetic epilepsy.

7 Feb 2024

AMG 133 (maridebart cafraglutide) weight loss drug shows promise in early trial

AMG 133, an engineered bispecific molecule, demonstrated significant weight loss with a favorable safety profile in a phase 1 clinical trial, offering a promising new treatment option for obesity.

7 Feb 2024

Immune cell networks key to success of personalized cancer treatment

Through an analysis of tumor samples collected over time from patients with advanced melanoma, a Ludwig Cancer Research study has identified a set of preexisting conditions in tumors that predict whether such patients are likely to respond to a personalized immunotherapy known as adoptive T cell therapy (ACT) using tumor-infiltrating lymphocytes (TIL).

7 Feb 2024

Researchers develop new approach to improve the accuracy of RNA sequencing

A team at NDORMS, University of Oxford has developed a new approach to significantly improve the accuracy of RNA sequencing.

7 Feb 2024

Academia's drug discovery challenges: Exploring the "publication landfill"

A new editorial paper was published in Oncotarget's Volume 15 on January 24, 2024, entitled, "The fate of drug discovery in academia; dumping in the publication landfill?"

6 Feb 2024

RvT4 molecule boosts the body's defenses against atherosclerosis in rheumatoid arthritis patients

Researchers from Queen Mary University of London have found that the molecule RvT4 enhances the body's natural defences against atherosclerosis (hardening of the arteries) in patients with rheumatoid arthritis.

6 Feb 2024

Paxlovid enhances treatment options for COVID-19 patients

The design, synthesis, and mechanism of action of Paxlovid.

6 Feb 2024

Researchers identify the basic principles of serotonin transport in nerve cells

Drugs known as antidepressants target the serotonin transporter in nerve cells and are among the most commonly prescribed medicines worldwide, but are sometimes associated with significant side effects.

5 Feb 2024

New research facility at the University of Surrey could soon unlock the secrets of diseases

A new research facility at the University of Surrey could soon help society better understand various diseases or even help scientists trace nanoplastics through the bodies and cells of humans and animals.

5 Feb 2024

New approach to treating neuropathic pain offers the possibility of non-opioid pain relief for millions

Researchers investigated the selective activity of sigmoid 2 receptor (σ2R) or transmembrane protein 97 (TMEM97) ligands on murine neuropathic pain models, their effects on nociceptive neurons and the mechanism of action after 24 hours.

5 Feb 2024

SCIEX expands high-throughput screening solutions with Echoâ MS+ system

The Echo® MS+ system unlocks enhanced high-throughput screening capability by bringing acoustic ejection mass spectrometry (AEMS) approaches to the SCIEX ZenoTOF 7600 system.

From SCIEX 5 Feb 2024

Tecan offers end-to-end solutions for cellomics: automated workflows from single-cell dispensing to 3D spheroid analysis

Tecan is proud to offer end-to-end cellomics workflow solutions, including cell seeding and culture with quality control and monitoring, through drug dosing to live-cell imaging and analysis. This comprehensive offering enables laboratories to improve the reliability, reproducibility and throughput of their workflows, addressing key challenges in the growing field of 3D cell biology.

5 Feb 2024

Small-molecule A485 mobilizes white blood cells on demand

New study reveals a small molecule that can selectively mobilize white blood cells, offering potential treatments for diseases with abnormal leukocyte counts.

3 Feb 2024

CAR T cells target senescent cells, improve healthspan in mice

Chimeric antigen receptor (CAR) T cells have transformed the treatment of blood cancers in recent years. And there have been positive signs the "living drugs" can be harnessed against other diseases, like autoimmune disorders.

2 Feb 2024

New molecule is one step closer to becoming a treatment for Phelan-McDermid syndrome

A molecule created at the University of Auckland is one step closer to becoming a treatment for an extremely rare and severely debilitating neurological disorder called Phelan-McDermid syndrome.

2 Feb 2024

Next-gen BTK degrader could help overcome treatment resistance in chronic lymphocytic leukemia

New research from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations has identified a next-generation BTK degrader that could help overcome treatment resistance in chronic lymphocytic leukemia (CLL) and related blood cancers.

1 Feb 2024

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

One of the major challenges in cancer research and clinical care is understanding the molecular basis for therapeutic resistance as a major cause of long term treatment failures.

1 Feb 2024

X-chromosome inactivation and its role in autoimmune susceptibility in females

Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women.

1 Feb 2024

Molecule News and Research

New drug targets key mechanism in ALS, protects motor neurons

Targeting gene-fibroblast interaction offers hope for treatment-resistant colon cancer

New treatment target found for CDKL5 deficiency disorder

AMG 133 (maridebart cafraglutide) weight loss drug shows promise in early trial

Immune cell networks key to success of personalized cancer treatment

Researchers develop new approach to improve the accuracy of RNA sequencing

Academia's drug discovery challenges: Exploring the "publication landfill"

RvT4 molecule boosts the body's defenses against atherosclerosis in rheumatoid arthritis patients

Paxlovid enhances treatment options for COVID-19 patients

Researchers identify the basic principles of serotonin transport in nerve cells

New research facility at the University of Surrey could soon unlock the secrets of diseases

New approach to treating neuropathic pain offers the possibility of non-opioid pain relief for millions

SCIEX expands high-throughput screening solutions with Echoâ MS+ system

Tecan offers end-to-end solutions for cellomics: automated workflows from single-cell dispensing to 3D spheroid analysis

Small-molecule A485 mobilizes white blood cells on demand

CAR T cells target senescent cells, improve healthspan in mice

New molecule is one step closer to becoming a treatment for Phelan-McDermid syndrome

Next-gen BTK degrader could help overcome treatment resistance in chronic lymphocytic leukemia

Specific epigenetic pathway found to be involved in the development of melanoma drug resistance

X-chromosome inactivation and its role in autoimmune susceptibility in females

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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