Morphine

Morphine is an extremely potent opiate analgesic psychoactive drug and is considered to be the prototypical opioid. In clinical medicine, morphine is regarded as the gold standard, or benchmark, of analgesics used to relieve severe or agonizing pain and suffering.

What is Morphine?

Morphine is the most abundant analgesic opiate found in opium and is a potent pain reliever. The drug is used in clinical pain relief but is also used illicitly for recreational purposes among drug users. It is potentially highly addictive and can cause intense physical dependence that leads to abuse of the substance.

Morphine History

Morphine Side Effects

Morphine Pharmacology

Morphine Pharmacokinetics

Morphine Chemistry

Morphine Brands

Morphine Uses

Latest Morphine News and Research

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems -; prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same pain relief, and paradoxically, prolonged use also can create an extreme sensitivity to pain, called hyperalgesia.

9 Apr 2024

Eating fatty food before surgery may affect memory-related cognitive function in older adults

Eating fatty food in the days leading up to surgery may prompt a heightened inflammatory response in the brain that interferes for weeks with memory-related cognitive function in older adults – and, new research in animals suggests, even in young adults.

15 Mar 2024

West Virginia city once battered by opioid overdoses confronts ‘fourth wave’

From 2006 through 2014, more than 81 million painkiller pills were shipped to this city and surrounding rural Cabell County.

13 Mar 2024

DNA aptamer-based sensors can accurately detect trace amounts of fentanyl, heroin, and cocaine

Researchers from North Carolina State University have developed a new generation of high-performance DNA aptamers and highly accurate drug sensors for cocaine and other opioids.

5 Mar 2024

Records show Publix opioid sales grew even as addiction crisis prompted other chains’ pullback

An executive at Teva Pharmaceuticals flagged Publix Super Markets in October 2015 after detecting what he called in an email "serious red flags" with the grocery chain's orders of powerful opioids.

29 Jan 2024

Morphine shows potential as effective cough therapy for pulmonary fibrosis, study finds

The efficacy of the controlled release of low-dose morphine as treatment against that of a placebo in idiopathic pulmonary fibrosis.

18 Jan 2024

New study challenges "gold standard" opioid treatment for cancer pain

Researchers examining the data on opioids for pain caused by cancer have found surprisingly large gaps in evidence regarding the true benefits of these medicines for cancer pain.

18 Dec 2023

New study casts doubt on effectiveness of opioids for cancer pain

The world's largest review on opioid medicines for cancer pain has found it is unclear whether some commonly used opioid medicines are better than a placebo and suggests that non-opioid medicines, including aspirin, may be as effective as opioids.

18 Dec 2023

Promising candidate medication for preventing and reversing fentanyl-induced overdose

Researchers assessed CSX-1004, a monoclonal antibody (mAb), for its efficacy in reversing fentanyl overdose based on its high affinity for fentanyl, positive animal model results, and safe pharmacokinetic profile, positioning it as a potential solution in the opioid crisis.

7 Dec 2023

MedUni Vienna scientists discover new pain medication with fewer side effects

People with chronic pain are often dependent on drugs from the class of opioids with sometimes considerable side effects.

6 Dec 2023

Evolving overdose crisis shakes previously effective treatments

"You can't inject a horse tranquilizer and think nothing bad is gonna happen" to you, said Ty Sears, 33, a longtime drug user now in recovery.

21 Nov 2023

Virtual reality vs. opioids: clinical trial of non-pharmacological pain management during burn wound care

Researchers assessed the feasibility and efficacy of virtual reality as a non-pharmaceutical intervention for managing procedural pain in adult burn patients during dressing changes compared to standard opioid-based approaches.

28 Sep 2023

Study: Drug overdose deaths in the U.S. more than quadrupled from 1999 to 2020

The United States is experiencing its highest overall death rates in more than a century, fueled in part by drug overdose mortality. The origins of the current epidemic are due, at least in part, to a 1986 World Health Organization pronouncement that pain treatment is a universal right.

12 Sep 2023

Enhanced recovery program shows promise in reducing opioid reliance after pancreatic cancer surgery

By improving hospital care pathways, researchers from The University of Texas MD Anderson Cancer Center successfully reduced inpatient opioid use by 50% after pancreatic cancer surgery and cut the median opioid prescription volumes at discharge to zero.

6 Sep 2023

Fentanyl overdose reversal: New hope on the horizon

According to the Centers for Disease Control, 100,000 Americans die each year from an overdose, most due to the use of synthetic opiates like fentanyl. While naloxone, currently the only an antidote for opiate overdose, has become more common, it is less effective against fentanyl-class synthetic opioids.

18 Jul 2023

Opioids linked to increased risk of death in older adults with dementia

The study population included everyone in Denmark aged 65 and older diagnosed with dementia between Jan. 1, 2008 and Dec. 31, 2018 (n=75,471), including both home-living and nursing home residents. Of that group, 42% (31,619) of those diagnosed with dementia redeemed a prescription for an opioid at a pharmacy.

18 Jul 2023

The American Journal of Health Economics articles examine policies to address opioid crisis

The August 2023 issue of the American Journal of Health Economics will feature a cluster of articles that examine the opioid crisis.

10 Jul 2023

Breaking the myth: opioids provide no advantage for acute back pain, study finds

The first placebo-controlled trial of opioids in acute low back and neck pain.

3 Jul 2023

Understanding factors associated with long-term opioid use in fibromyalgia patients

Fibromyalgia is common, affecting around 2% of people in the general population. The 2017 EULAR recommendations state that tramadol - a weak opioid - may be considered for pain management in fibromyalgia, but advise against use of strong opioids due to lack of evidence of efficacy, and the high risk of side effects and addiction.

2 Jun 2023

Special issue aims to deepen the conversation around cerebral palsy

Although cerebral palsy (CP) is the most common childhood-onset disability, there are very few evidence-based clinical practice guidelines or recommendations on how to treat and manage this condition.

31 May 2023

Morphine

Overview

Morphine History

Morphine Side Effects

Morphine Pharmacology

Feature Articles

Morphine Pharmacokinetics

Morphine Chemistry

Morphine Brands

Morphine Uses

Latest Morphine News and Research

Tiam1 inhibition mitigates morphine tolerance and hyperalgesia in mouse model

Eating fatty food before surgery may affect memory-related cognitive function in older adults

West Virginia city once battered by opioid overdoses confronts ‘fourth wave’

DNA aptamer-based sensors can accurately detect trace amounts of fentanyl, heroin, and cocaine

Records show Publix opioid sales grew even as addiction crisis prompted other chains’ pullback

Morphine shows potential as effective cough therapy for pulmonary fibrosis, study finds

New study challenges "gold standard" opioid treatment for cancer pain

New study casts doubt on effectiveness of opioids for cancer pain

Promising candidate medication for preventing and reversing fentanyl-induced overdose

MedUni Vienna scientists discover new pain medication with fewer side effects

Evolving overdose crisis shakes previously effective treatments

Virtual reality vs. opioids: clinical trial of non-pharmacological pain management during burn wound care

Study: Drug overdose deaths in the U.S. more than quadrupled from 1999 to 2020

Enhanced recovery program shows promise in reducing opioid reliance after pancreatic cancer surgery

Fentanyl overdose reversal: New hope on the horizon

Opioids linked to increased risk of death in older adults with dementia

The American Journal of Health Economics articles examine policies to address opioid crisis

Breaking the myth: opioids provide no advantage for acute back pain, study finds

Understanding factors associated with long-term opioid use in fibromyalgia patients

Special issue aims to deepen the conversation around cerebral palsy

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

Morphine

Overview

Feature Articles

Morphine Pharmacokinetics

Morphine Chemistry

Morphine Brands

Morphine Uses

Latest Morphine News and Research

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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