Mouse Model News and Research

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Time-restricted feeding reverses Alzheimer's symptoms in mice, offers new hope for accessible treatment

Researchers explore the therapeutic potential of circadian-modulating interventions to treat Alzheimer’s disease.

27 Aug 2023

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

In 2012, University of Alabama at Birmingham researcher Anath Shalev, M.D., reported that a decades-old blood pressure medication called verapamil completely reversed diabetes in animal models.

25 Aug 2023

Naked mole rat gene boosts health and longevity in mice

In a groundbreaking endeavor, researchers at the University of Rochester have successfully transferred a longevity gene from naked mole rats to mice, resulting in improved health and an extension of the mouse's lifespan.

23 Aug 2023

Gut-first theory of Parkinson's disease gains traction

Ask any neurologist: Parkinson's disease is a brain disorder. The conspicuous symptoms of Parkinson's disease-;uncontrollable tremors, slowed down motions, and the feeling that one's feet are stuck to the ground-;all stem from the loss of neurons in a region of the brain that helps control movement.

22 Aug 2023

Time-restricted feeding may correct the circadian disruptions in Alzheimer's disease

One of the hallmarks of Alzheimer's disease is disruption to the body's circadian rhythm, the internal biological clock that regulates many of our physiological processes.

21 Aug 2023

Proxalutamide shows promise as potential COVID-19 treatment

At the outset of the COVID pandemic, men appeared to suffer higher rates of severe illness and death, leading researchers to suspect a link between androgen receptors-;which bind to hormones like testosterone--and SARS-CoV-2 viral infection.

18 Aug 2023

Scientist receives $6.8M grant to study how environmental chemicals increase CVD risk

Exposure to environmental chemicals, including those in common plastic products, has been linked with an increased risk of cardiovascular disease, or CVD, the leading cause of death worldwide. According to the World Health Organization, 17.9 million people died from CVDs in 2019.

16 Aug 2023

Researchers design one-step procedure for improving effective of adoptive cell immunotherapy against solid tumors

Researchers developed a one-step method to engineer multifunctional M1 phenotype macrophages.

14 Aug 2023

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

The researchers demonstrated that glucokinase activation was effective in lowering blood glucose in mice with high-fat diet-induced obesity, while it potentially raised the risk of increasing hepatic lipid accumulation that triggered the PERK-UPR pathway.

11 Aug 2023

Genetically diverse mice reveal key differences in innate immune responses to SARS-CoV-2

Researchers at The Jackson Laboratory have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection.

11 Aug 2023

New mechanism discovered for brain repair after ischemic stroke

Patients often experience functional decline after an ischemic stroke, especially due to the brain's resistance to regenerate after damage.

10 Aug 2023

New gene-editing tool helps to study single-base mutations in cancer

A change in just one letter in the code that makes up a cancer-causing gene can significantly affect how aggressive a tumor is or how well a patient with cancer responds to a particular therapy.

10 Aug 2023

Study provides clues to how harmful T cells cause heart disease

Scientists can finally hunt down a harmful kind of human T cell, thanks to new research led by scientists at La Jolla Institute for Immunology (LJI) and the Medical College of Georgia (MCG) at Augusta University.

10 Aug 2023

Scientists develop novel animal model of neurobrucellosis

Neurobrucellosis is a severe long-term complication of brucellosis, one of the most common bacterial zoonotic diseases.

10 Aug 2023

Stem cell transplants may be a promising therapeutic against Alzheimer's, study shows

In the ongoing search for a cure for Alzheimer's disease, a burgeoning branch of medicine is bringing new hope. Stem cell therapies are already being used to treat various cancers and disorders of the blood and immune system.

9 Aug 2023

Yale researchers create "humanized" liver in living mice to study chronic liver diseases

Yale researchers have created a functional "humanized" liver in living mice that will help scientists find human-specific mechanisms for regulating cholesterol levels and potentially for treating chronic liver diseases afflicting tens of millions of people in the United States.

9 Aug 2023

Mouse Model News and Research

Time-restricted feeding reverses Alzheimer's symptoms in mice, offers new hope for accessible treatment

UAB researchers show beneficial effect of verapamil for patients with Type 1 diabetes

Naked mole rat gene boosts health and longevity in mice

Gut-first theory of Parkinson's disease gains traction

Time-restricted feeding may correct the circadian disruptions in Alzheimer's disease

Proxalutamide shows promise as potential COVID-19 treatment

Scientist receives $6.8M grant to study how environmental chemicals increase CVD risk

Researchers design one-step procedure for improving effective of adoptive cell immunotherapy against solid tumors

Glucokinase activators induce hepatic lipid accumulation in mice with high-fat diet

Genetically diverse mice reveal key differences in innate immune responses to SARS-CoV-2

New mechanism discovered for brain repair after ischemic stroke

New gene-editing tool helps to study single-base mutations in cancer

Study provides clues to how harmful T cells cause heart disease

Scientists develop novel animal model of neurobrucellosis

Stem cell transplants may be a promising therapeutic against Alzheimer's, study shows

Yale researchers create "humanized" liver in living mice to study chronic liver diseases

Mice lacking TMCO3 gene have shortened bones

Mass spectrometry-based secretome approach reveals key players in astroglial barrier function

Are mushrooms an effective early dietary intervention for Alzheimer’s Disease?

CAR-T immune therapies could be effective against solid tumors

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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