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Groundbreaking study identifies FAM3C as a key regulator of breast cancer progression

A groundbreaking study conducted by Professor Jiyoung Park and her research team in the Department of Biological Sciences at UNIST has identified FAM3C, a metabolism-regulating signaling molecule produced by cancer-associated adipocytes (CAAs), as a key regulator of breast cancer progression within the tumor microenvironment (TME).

19 Jan 2024

Prior mycobacterium exposure remodels immune cells, impacting tuberculosis defense

Tuberculosis, caused by the bacterium Mycobacterium tuberculosis (Mtb) kills upwards of 1.6 million people a year, making it one of the leading causes of death by an infectious agent worldwide-;and that number is only growing larger.

18 Jan 2024

UNC scientists develop "smart" patch for precision drug delivery

University of North Carolina at Chapel Hill scientists created a new drug delivery system, called the Spatiotemporal On-Demand Patch (SOP), which can receive commands wirelessly from a smartphone or computer to schedule and trigger the release of drugs from individual microneedles.

18 Jan 2024

DNA origami used to unveil novel Notch receptor activation pathway

Researchers at Karolinska Institutet in Sweden have used DNA origami, the art of folding DNA into desired structures, to show how an important cell receptor can be activated in a previously unknown way.

18 Jan 2024

The role of glucose in inducing tolerance to amphotericin B for fungal meningitis treatment

Researchers investigate the mechanism responsible for amphotericin B tolerance of Cryptococcus neoformans.

18 Jan 2024

New bioengineered strategy shows potential for treating ulcerative colitis

By taking advantage of mechanisms that allow cancer cells to evade immune attack, UT Southwestern Medical Center researchers have developed a new strategy in animal models that has potential for treating ulcerative colitis.

17 Jan 2024

Breakthrough nano-shield blocks selective allergic reactions

Northwestern University researchers have developed the first selective therapy to prevent allergic reactions, which can range in severity from itchy hives and watery eyes to trouble breathing and even death.

16 Jan 2024

Nanobots for bladder cancer treatment, promising high efficacy and targeted delivery

A study in Nature Nanotechnology reveals the potential of urease-powered nanobots to enhance bladder cancer treatment, showing a 90% tumor reduction in a mouse model using radioiodine-loaded nanobots for targeted therapy.

15 Jan 2024

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

This new article publication from Acta Pharmaceutica Sinica B, discusses how GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.

15 Jan 2024

Nicotine's surprising effect on gut microbiota and metabolism uncovered

The impact of nicotine exposure on host nutritional status, gut microbial metabolites, and metabolic homeostasis.

15 Jan 2024

Study explores intratumoral microbiota as a novel frontier in cancer research

Researchers review the role of intratumoral microbiota in cancer development, suggesting its potential in predicting and treating various cancers.

14 Jan 2024

New approach using ultrasound-guided drug delivery effectively targets lymph node metastasis

Researchers at Tohoku University have discovered a new approach for treating lymph node metastasis. Anticancer drugs are administered directly into the LNs under ultrasound guidance (Lymphatic Drug Delivery System or LDDS) to target sentinel lymph nodes (LNs) and generate antitumor effects locally, preventing distant metastasis.

12 Jan 2024

Study sheds light on how impaired autophagy can play a role in causing heart failure

A new study sheds light on how autophagy, the body's process for removing damaged cell parts, when impaired, can play a role in causing heart failure.

11 Jan 2024

Glioblastoma tumor cells mimic neurons to evade treatment

Certain cancers are more difficult to treat because they contain cells that are highly skilled at evading drugs or our immune systems by disguising themselves as healthy cells.

11 Jan 2024

mRNA therapy shows promise for curing children's rare liver disease

By exploiting the technology used in Covid-19 vaccines, a team led by UCL, King's College London and Moderna scientists has created an effective therapy for a rare disease, in a study in mice, demonstrating the technology's potential therapeutic use in people.

10 Jan 2024

Blocking brain inflammation could slow, reverse ALS symptoms

In people with amyotrophic lateral sclerosis (ALS), changes in neurons appear to activate immune cells. Lowering the inflammation could reduce the symptoms of the disease, according to a study led by Chantelle Sephton, a professor at Université Laval's Faculty of Medicine.

10 Jan 2024

MedUni Vienna researchers discover possible trigger of chronic inflammatory bowel disease

As the cause of chronic inflammatory bowel diseases (IBD) such as Crohn's disease or ulcerative colitis is not yet known, treatment for sufferers is currently aimed at alleviating the often agonizing symptoms.

10 Jan 2024

First-of-its-kind research shines light on how certain pathogens can outwit the body's immune system

In a first-of-its-kind research breakthrough, a team of scientists at the University of Massachusetts Amherst has analyzed and described what they call the "mosquito effect," which sheds light on how certain pathogens, such as cancerous tumor cells, can outwit the body's immune system.

8 Jan 2024

Three cytokine pairs found to be responsible for the body's damaging response to sepsis

Sepsis -; when an infection causes the immune system to improperly target the body -; is one of the leading causes of death in the ICU.

8 Jan 2024

Revolutionary study reveals Lactobacillus acidophilus could ward off liver cancer linked to fatty liver disease

Probiotic supplementation with Lactobacillus acidophilus could help prevent non-alcoholic fatty liver disease.

8 Jan 2024

Mouse Model News and Research

Groundbreaking study identifies FAM3C as a key regulator of breast cancer progression

Prior mycobacterium exposure remodels immune cells, impacting tuberculosis defense

UNC scientists develop "smart" patch for precision drug delivery

DNA origami used to unveil novel Notch receptor activation pathway

The role of glucose in inducing tolerance to amphotericin B for fungal meningitis treatment

New bioengineered strategy shows potential for treating ulcerative colitis

Breakthrough nano-shield blocks selective allergic reactions

Nanobots for bladder cancer treatment, promising high efficacy and targeted delivery

GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in rheumatoid arthritis

Nicotine's surprising effect on gut microbiota and metabolism uncovered

Study explores intratumoral microbiota as a novel frontier in cancer research

New approach using ultrasound-guided drug delivery effectively targets lymph node metastasis

Study sheds light on how impaired autophagy can play a role in causing heart failure

Glioblastoma tumor cells mimic neurons to evade treatment

mRNA therapy shows promise for curing children's rare liver disease

Blocking brain inflammation could slow, reverse ALS symptoms

MedUni Vienna researchers discover possible trigger of chronic inflammatory bowel disease

First-of-its-kind research shines light on how certain pathogens can outwit the body's immune system

Three cytokine pairs found to be responsible for the body's damaging response to sepsis

Revolutionary study reveals Lactobacillus acidophilus could ward off liver cancer linked to fatty liver disease

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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