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Drugs that act on 'fasting signal' may curb insulin resistance in obese

A report in the March issue of Cell Metabolism , a Cell Press publication, has found that a signal known to play a role during fasting also switches on early in the fat tissue of obese mice as they progress toward type 2 diabetes.

2 Apr 2009

Researchers discover structure-building role for 2 non-coding RNAs

Most of the DNA in the nucleus of each of our cells is converted into RNA, but only a small fraction of these RNA molecules serve as coding templates for the synthesis of proteins.

2 Apr 2009

Accurate assessment of heart disease leads to earlier, more aggressive therapy

In a study comparing the ability of various medical techniques to accurately determine the extent of heart disease and stratify patients according to disease severity, researchers found that myocardial perfusion testing with gated single photon emission computed tomography (gated SPECT) was a more accurate predictor of prognosis in chronic ischemic heart disease (IHD)-a painful condition caused by a temporary reduction of oxygen-rich blood to the heart.

1 Apr 2009

Novel assays provide new insight into why patients are in heart failure

A failing heart makes a lot of a hormone needed to eliminate the excess salt and water bloating the body but not enough of the enzyme needed to activate it, researchers say.

1 Apr 2009

Eye exercises help patients work out vision problems

You've probably been there. In a doctor's office, being advised to do what you dread - exercise.

1 Apr 2009

Ultrasound saves money, improves rheumatologic care

A few years back, 76-year-old Joseph Buggie woke up to pain so throbbing, he couldn't muster the strength to roll over, let alone crawl out of bed.

31 Mar 2009

Octogenarian muscles don't strengthen with exercise

Octogenarian women were unable to increase muscle mass after a 3-month weight lifting program targeted at strengthening the thigh muscle, according to a new study from the Journal of Applied Physiology.

31 Mar 2009

Genetic engineering breakthrough

In a genetic engineering breakthrough that could help everyone from bed-ridden patients to elite athletes, a team of American researchers - including 2007 Nobel Prize winner Mario R. Capecchi - have created a "switch" that allows mutations or light signals to be turned on in muscle stem cells to monitor muscle regeneration in a living mammal

30 Mar 2009

In lab supplements of lipoic acid lower triglyceride levels

Studies done with laboratory rats suggest that supplementation of their diet with lipoic acid had a significant effect in lowering triglycerides, which along with cholesterol levels and blood pressure are one of the key risk factors in cardiovascular disease.

30 Mar 2009

Is transforming growth factor-beta involved in intestinal wound healing?

Migration of colonic lamina propria fibroblasts (CLPF) plays an important role during the progression of fibrosis and fistulae in Crohn's disease.

30 Mar 2009

Post heart attack, bone marrow stem cells increase blood flow within heart

Patients treated with their own bone marrow stem cells after a heart attack experienced increased circulation within the heart, a study by Emory University School of Medicine physicians has found.

30 Mar 2009

FDA approves IXIARO for Japanese encephalitis

The U.S. Food and Drug Administration has approved IXIARO, a vaccine to prevent Japanese encephalitis (JE) which is caused by a mosquito-transmitted virus found mainly in Asia. IXIARO will be the only vaccine for JE available in the United States.

30 Mar 2009

NTRILIPIX (fenofibric acid) in combo with Rosuvastatin calcium shows improvement on key lipids for cholesterol management

Data from a new study showed that Abbott's TRILIPIX (fenofibric acid) delayed-release capsules in combination with rosuvastatin calcium met all of the study's primary endpoints.

29 Mar 2009

Protein from tick saliva shows potential for myasthenia gravis treatment

Looking for a better treatment for the autoimmune disease myasthenia gravis, researchers have found that a protein in tick saliva shows promise in limiting the severity of the disease in an animal model in a study published in the Annals of Neurology.

29 Mar 2009

Study offers closer look at Takotsubo cardiomyopathy

"Broken heart syndrome" is still a mystery to many in the medical community, but new data from researchers at The Miriam Hospital may shed some light on the clinical characteristics and outcomes of this relatively rare, life-threatening condition.

29 Mar 2009

Recently identified genetic heart disorder often deadly for young patients

A study that included young patients with a recently recognized rare type of cardiomyopathy (a disorder of the heart muscle) linked to a genetic mutation finds that progression of this disease may be rapid and often results in early death, according to a study in the March 25 issue of JAMA.

24 Mar 2009