Muscle Atrophy News and Research

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Looking at cancer drugs to help put the brakes on classic indicators of aging

Antiretroviral cocktails can make human immunodeficiency virus, or HIV, undetectable and untransmittable, but both the virus and its treatment can also accelerate aging of bone and muscle.

24 May 2023

Researchers discover molecular pathway that mediates cancer-associated muscle atrophy

Nearly half of all cancer patients suffer from excessive weight loss due to the loss of adipose and skeletal muscle tissues, or cachexia.

18 May 2023

Experts provide a new clinical picture of sarcopenic obesity

Proteins and weight training could help if obese patients are suffering from muscle atrophy. However, the problem is usually not recognized, according to Prof. Dr. Bischoff from the University of Hohenheim.

15 May 2023

Researchers discover a receptor and protein associated with Lou Gehrig's disease

Researchers at Nagoya University in Japan have discovered a receptor, sigma-1 receptor, and a protein, ATAD3A, that are associated with Amyotrophic Lateral Sclerosis (ALS), also known as Lou Gehrig's disease.

25 Apr 2023

UH researcher examines the causes of skeletal muscle atrophy

Skeletal muscle atrophy, or wasting, is a devastating and often irreversible syndrome during the aging process and for patients with advanced cancer.

11 Apr 2023

Researchers fabricate first wearable sensor to detect and monitor muscle atrophy

Researchers at The Ohio State University have fabricated the first wearable sensor designed to detect and monitor muscle atrophy.

17 Mar 2023

Innate immune molecule could be at the root of ALS

While drugs are on the market to slow the progression of neurodegenerative diseases, there are still no cures.

13 Mar 2023

Resistance exercise improves sleep and inflammatory status in sarcopenic older patients

Sarcopenia is the decline of skeletal muscle mass with age, leading to loss of muscle strength (to move objects, shake hands etc.) and performance (walking and making other routine movements effectively). It involves chronic inflammation and is associated with cognitive alterations, heart disease and respiratory disorders.

2 Mar 2023

Study shows COVID-19 induces body fat and other metabolic changes

In a recent study published in the journal Cureus, researchers explored the relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and levels of serum insulin, body fat distribution, and insulin resistance (IR) estimated by homeostasis model assessment (HOMA).

29 Jan 2023

Vitamin D supplements reduce the risk of dynapenia in older people by 78%

Vitamin D plays an important role in the regulation of calcium and phosphorus absorption by the organism.

13 Dec 2022

Many genetic disorders respond well to specialized gene therapy

When the normal DNA sequence in an individual changes or mutates it can cause disease. The mutation may involve multiple genes and may be caused by environmental factors, or there may be chromosomal defects that are harmful at birth, in infancy or environment at a later stage.

12 Dec 2022

Mechanically active adhesive prevents and supports the recovery from muscle atrophy

Muscles waste as a result of not being exercised enough, as happens quickly with a broken limb that has been immobilized in a cast, and more slowly in people reaching an advanced age.

14 Nov 2022

New studies point to a broadly applicable treatment for neurodegenerative diseases

Two new studies from Washington University School of Medicine in St. Louis support development of a broadly applicable treatment for neurodegenerative diseases that targets a molecule that serves as the central executioner in the death of axons, the wiring of the nervous system.

26 Oct 2022

First-of-its-kind messenger RNA therapy developed for ovarian cancer, cachexia

Researchers at Oregon State University and Oregon Health & Science University have developed a promising, first-of-its-kind messenger RNA therapy for ovarian cancer as well as cachexia, a muscle-wasting condition associated with cancer and other chronic illnesses.

13 Sep 2022

Blocking FNDC5 prevents cancer-induced cachexia in mice

The severe muscle atrophy and weakness commonly associated with cancer growth (i.e., cachexia) can be prevented simply by being deprived of FNDC5, the precursor of the exercise hormone irisin, researchers from the Indiana University School of Medicine have found.

12 Sep 2022

Novel tool evaluates the contractile force-related state of myotubes

Researchers from Tokyo Metropolitan University have developed a way to characterize the force generated by contracting myotubes, precursors to skeletal muscle fiber, combining electrostimulation and analysis of wrinkles in the silicone substrate on which they are mounted. Existing methods rely on muscle mass or the expression of certain proteins, both not as strongly correlated with muscle strength. Accurate measurement of myotube strength promises more effective screening of drug targets for treating muscle atrophy.

5 Sep 2022

Novel member of a class of anti-diabetes drugs could help treat muscle wasting disease

Inflammatory myopathies can be challenging to treat, but a new study reports encouraging findings for patients with these debilitating conditions. Researchers from Japan have found that a novel member of a class of anti-diabetes drugs could be the key to treating patients with muscle wasting disease.

18 Aug 2022

Regular cycling can improve mobility in patients with myotonic dystrophy

A study led by McMaster University researchers has found that regular cycling can greatly improve mobility in patients with myotonic dystrophy (MD), a genetic disease that causes muscle degeneration.

11 Apr 2022

Vitamin C may help to counteract common side effect of the chemotherapy drug

A study conducted in rats suggests that taking vitamin C may help to counteract the muscle atrophy that is a common side effect of the chemotherapy drug doxorubicin.

4 Apr 2022

Study shows the benefits of once-weekly prednisone in obese mice

Obese mice that were fed a high-fat diet and that received prednisone one time per week had improved exercise endurance, got stronger, increased their lean body mass and lost weight, reports a new Northwestern Medicine study published in The Journal of Experimental Medicine.

1 Apr 2022