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Study shows cellular, molecular overlaps in ALS and FTLD

On the surface, the movement disorder amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and the cognitive disorder frontotemporal lobar degeneration (FTLD), which underlies frontotemporal dementia, manifest in very different ways. In addition, they are known to primarily affect very different regions of the brain.

22 Mar 2024

Scientists uncover four proteins that govern the identity of anaplastic large cell lymphoma

A collaboration between scientists from St. Jude Children's Research Hospital and Dana-Farber Cancer Institute uncovered four proteins that govern the identity of anaplastic large cell lymphoma (ALCL), an aggressive form of cancer.

22 Mar 2024

Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer

Researchers at the University of Zurich and the University Hospital Zurich have discovered that a specific mutation in the cancer cells of an aggressive type of blood cancer can prevent novel immunotherapies such as CAR T-cell therapy from working.

21 Mar 2024

Enhancing the safety and efficacy of breast and ovarian cancer treatment

Some anti-cancer treatments not only target tumour cells but also healthy cells. If their effects on the latter are too strong, their use can become limiting.

20 Mar 2024

Immune cell protein identified as potential target for rare liver cancer treatment

Fibrolamellar carcinoma (FLC) is a rare liver cancer with a poor prognosis if not addressed early with surgery. The disease is caused by a single genetic mutation that creates a fusion protein.

20 Mar 2024

Advanced laser imaging illuminates molecular interactions driving lung cancer growth

Researchers have shown for the first time that a crucial interface in a protein that drives cancer growth could act as a target for more effective treatments.

19 Mar 2024

Discovering the on-switch for rare genetic inflammatory diseases

University of Queensland researchers have discovered how the 'on-switch' for the body's inflammation machinery can get stuck and cause rare genetic inflammatory diseases.

18 Mar 2024

Study uncovers how APOBEC enzymes drive cancer mutations

A research team led by the University of California, Irvine has discovered the key role that the APOBEC3A and APOBEC3B enzymes play in driving cancer mutations by modifying the DNA in tumor genomes, offering potential new targets for intervention strategies.

18 Mar 2024

Researchers discover link between FBXW7 mutations and EGFR signaling in colorectal cancer

The Organoid group at the Hubrecht Institute have identified a new link between FBXW7 mutations and EGFR signaling activity.

18 Mar 2024

New fluid biomarker may one day detect ALS and FTD before symptoms appear

Two progressively degenerative diseases, amyotrophic lateral sclerosis (ALS, commonly known as Lou Gehrig's disease) and frontotemporal dementia (FTD, recently in the news with the diagnoses of actor Bruce Willis and talk show host Wendy Williams), are linked by more than the fact that they both damage nerve cells critical to normal functioning -; the former affecting nerves in the brain and spinal cord leading to loss of movement, the latter eroding the brain regions controlling personality, behavior and language.

18 Mar 2024

Study uncovers mutation impacting Alzheimer's progression

The scientist of the Faculty of Medicine of the University of Malaga José Luis Royo has coordinated a study that summarizes eight years of research and brings together 100 multidisciplinary specialists, identifying a mutation that alters Alzheimer's disease progression.

15 Mar 2024

New drug candidate designed at the atomic level could help halt emerging SARS-CoV-2 variants

Although COVID-19 has faded from the headlines, SARS-CoV-2 – the coronavirus behind the pandemic – is still rampantly infecting people around the world.

14 Mar 2024

NCCN updates treatment guidelines for high-incidence cancers

The National Comprehensive Cancer Network is announcing several new updates to the cancer treatment practices listed in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines).

14 Mar 2024

Novel CAR-T therapy shows promising results in glioblastoma patients

A collaborative project to bring the promise of cell therapy to patients with a deadly form of brain cancer has shown dramatic results among the first patients to receive the novel treatment.

13 Mar 2024

MIT researchers develop new method to quickly screen cancer-associated genetic mutations

Tumors can carry mutations in hundreds of different genes, and each of those genes may be mutated in different ways -; some mutations simply replace one DNA nucleotide with another, while others insert or delete larger sections of DNA.

12 Mar 2024

AI framework can identify and track new and concerning COVID-19 variants

Scientists at The Universities of Manchester and Oxford have developed an AI framework that can identify and track new and concerning COVID-19 variants and could help with other infections in the future.

11 Mar 2024

Childhood cancer survivors rarely up to date for recommended surveillance tests

Surviving childhood cancer does not always mean a clean bill of health, as the treatments that eradicate those cancers can put adult survivors at risk of new cancers and other serious health problems.

11 Mar 2024

Unveiling the molecular mechanism responsible for crossover interference during meiosis

Movies such as 'X-Men,' 'Fantastic Four,' and 'The Guardians,' which showcase vibrant mutant heroes, have captivated global audiences.

7 Mar 2024

Scientists design breakthrough drug to combat deadly pancreatic cancer mutation

Scientists discover a new way to disarm a deadly protein that also appears in cancers of the lung, breast and colon.

5 Mar 2024

Researchers take important step toward genetic therapy for hereditary conditions

Researchers who work with tiny drug carriers known as lipid nanoparticles have developed a new type of material capable of reaching the lungs and the eyes, an important step toward genetic therapy for hereditary conditions like cystic fibrosis and inherited vision loss.

5 Mar 2024

Mutation News and Research

Study shows cellular, molecular overlaps in ALS and FTLD

Scientists uncover four proteins that govern the identity of anaplastic large cell lymphoma

Concomitant pharmacotherapy overcomes immunotherapy challenges in aggressive blood cancer

Enhancing the safety and efficacy of breast and ovarian cancer treatment

Immune cell protein identified as potential target for rare liver cancer treatment

Advanced laser imaging illuminates molecular interactions driving lung cancer growth

Discovering the on-switch for rare genetic inflammatory diseases

Study uncovers how APOBEC enzymes drive cancer mutations

Researchers discover link between FBXW7 mutations and EGFR signaling in colorectal cancer

New fluid biomarker may one day detect ALS and FTD before symptoms appear

Study uncovers mutation impacting Alzheimer's progression

New drug candidate designed at the atomic level could help halt emerging SARS-CoV-2 variants

NCCN updates treatment guidelines for high-incidence cancers

Novel CAR-T therapy shows promising results in glioblastoma patients

MIT researchers develop new method to quickly screen cancer-associated genetic mutations

AI framework can identify and track new and concerning COVID-19 variants

Childhood cancer survivors rarely up to date for recommended surveillance tests

Unveiling the molecular mechanism responsible for crossover interference during meiosis

Scientists design breakthrough drug to combat deadly pancreatic cancer mutation

Researchers take important step toward genetic therapy for hereditary conditions

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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