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Broad-spectrum neutralizing antibody mAb-39 targets conserved S2 epitope in SARS-CoV-2

The ongoing COVID-19 pandemic caused by SARS-CoV-2 has caused serious damage to public health and the global economy, and one strategy to combat COVID-19 has been the development of broadly neutralizing antibodies for prophylactic and therapeutic use.

1 Mar 2024

Rare gene mutations in hereditary Alzheimer's disease disrupt amyloid production, study shows

A University of Kansas study of rare gene mutations that cause hereditary Alzheimer's disease shows these mutations disrupt production of a small sticky protein called amyloid.

29 Feb 2024

Study reveals high prevalence of BRCA1 and BRCA2 mutations in ovarian cancer patients from the Salento peninsula

A new research paper was published in Oncotarget's Volume 15 on February 22, 2024, entitled, "Prevalence and spectrum of germline BRCA1 and BRCA2 in a cohort of ovarian cancer patients from the Salento peninsula (Southern Italy): a matter of preventive health."

28 Feb 2024

Study reveals distinct molecular features of proximal and distal colon cancers

The colon is often thought of as one organ, but the right and left parts of the colon have different molecular features in cancers.

27 Feb 2024

Ancient Eastern Arabians developed malaria resistance through agriculture, study finds

People living in ancient Eastern Arabia appear to have developed resistance to malaria following the appearance of agriculture in the region around five thousand years ago, a new study reveals.

27 Feb 2024

Gut bacteria may be responsible for sight loss in certain inherited eye diseases

Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice co-led by a UCL and Moorfields researcher.

26 Feb 2024

Study uncovers a biological role of transmembrane protein TMEM208

A recent study conducted in the lab of Dr. Hugo J. Bellen, distinguished service professor at Baylor College of Medicine and principal investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children's Hospital, has discovered a biological role of a specific transmembrane protein called TMEM208.

23 Feb 2024

Key link discovered between spread of antibiotic resistance genes and drug resistance evolution

Biomedical engineers at Duke University have uncovered a key link between the spread of antibiotic resistance genes and the evolution of resistance to new drugs in certain pathogens.

23 Feb 2024

Research identifies cancer risk patterns in families of men with fertility problems

For the first time researchers have identified patterns of risk for several different types of cancer in men with fertility problems and their families.

22 Feb 2024

Mutation in E. coli bacteria linked to severe disease

Queensland researchers have discovered that a mutation allows some E. coli bacteria to cause severe disease in people while other bacteria are harmless, a finding that could help to combat antibiotic resistance.

21 Feb 2024

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

The recent approval of a CRISPR-Cas9 therapy for sickle cell disease demonstrates that gene editing tools can do a superb job knocking out genes to cure hereditary disease.

20 Feb 2024

Genetic mechanism shields bacterial communities from viral threats

Like humans struggling to get through the COVID-19 pandemic, bacterial cells need social distancing to thwart viruses.

16 Feb 2024

Study suggests CT imaging with automated AI system predicts EGFR genotype, identifying mutation status cost-effectively and non-invasively

Researchers developed an artificial intelligence (AI)-based predictive system (AIPS) model for the early detection of lung cancer by combining radiological, clinical, and genetic data.

16 Feb 2024

Next-generation sequencing and machine learning used to map genetic landscape of pancreatic cancer

A new research paper was published in Oncotarget's Volume 15 on February 5, 2024, entitled, "Genetic and therapeutic landscapes in cohort of pancreatic adenocarcinomas: next-generation sequencing and machine learning for full tumor exome analysis."

15 Feb 2024

City of Hope cures oldest person of blood cancer and achieves HIV remission

City of Hope, one of the largest cancer research and treatment organizations in the United States, treated the oldest person to be cured of a blood cancer and then achieve remission for HIV after receiving a blood stem cell transplant from a donor with a rare genetic mutation.

15 Feb 2024

Combo of targeted and immunotherapy may boost NSCLC treatment by overcoming immune resistance and enhancing anti-tumor activity

Researchers evaluated rational combination treatment regimens for advanced/metastatic non-small-cell lung cancer (NSCLC).

15 Feb 2024

Mutation News and Research

Broad-spectrum neutralizing antibody mAb-39 targets conserved S2 epitope in SARS-CoV-2

Rare gene mutations in hereditary Alzheimer's disease disrupt amyloid production, study shows

Study reveals high prevalence of BRCA1 and BRCA2 mutations in ovarian cancer patients from the Salento peninsula

Study reveals distinct molecular features of proximal and distal colon cancers

Ancient Eastern Arabians developed malaria resistance through agriculture, study finds

Gut bacteria may be responsible for sight loss in certain inherited eye diseases

Study uncovers a biological role of transmembrane protein TMEM208

Key link discovered between spread of antibiotic resistance genes and drug resistance evolution

Research identifies cancer risk patterns in families of men with fertility problems

Mutation in E. coli bacteria linked to severe disease

Breakthrough gene therapy method utilizes bird retrotransposon for safe gene insertion

Genetic mechanism shields bacterial communities from viral threats

Study suggests CT imaging with automated AI system predicts EGFR genotype, identifying mutation status cost-effectively and non-invasively

Next-generation sequencing and machine learning used to map genetic landscape of pancreatic cancer

City of Hope cures oldest person of blood cancer and achieves HIV remission

Combo of targeted and immunotherapy may boost NSCLC treatment by overcoming immune resistance and enhancing anti-tumor activity

Study uncovers more than one hundred key genes linked to DNA damage

Breakthrough research unveils effects of ionizing radiation on cellular DNA

Advanced melanoma survival rates improve significantly from 2013 to 2019, Dutch study finds

Understanding how natural genetic variation contributes to adaptive responses to low oxygen

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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