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MIT researchers design stealth drug delivery system to attack TNBC cells

Some of the most dangerous cancers are those that can outmaneuver the very drugs designed to defeat them, but researchers are now reporting a new Trojan-horse approach. In a preliminary study in the journal ACS Nano focusing on a type of breast cancer that is highly resistant to current therapies, they describe a way to sneak small particles into tumor cells, lower their defenses and attack them with drugs, potentially making the therapy much more effective.

25 Oct 2013

UMMS professor receives EUREKA grant to develop light activated nanoparticles for imaging brain tissue

University of Massachusetts Medical School Assistant Professor of Biochemistry and Molecular Pharmacology Gang Han, PhD, has received a $1.3 million EUREKA (Exceptional Unconventional Research Enabling Knowledge Acceleration) grant from the National Institute of Mental Health to develop light activated nanoparticles that can be used to image live brain tissue.

25 Oct 2013

"One-two punch" disables tumors' defenses

An aggressive form of breast cancer known as "triple negative" is very difficult to treat: Chemotherapy can shrink such tumors for a while, but in many patients they grow back and gain resistance to the original drugs.

25 Oct 2013

Nanopharmaceutical drug shows promise for cancers that resist antiangiogenic drugs

The nanopharmaceutical drug CRLX101 is showing promise as a potential new treatment for cancers that develop resistance to antiangiogenic drugs and radiation therapy, according to clinical trial results presented here at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, held Oct. 19 - 23.

22 Oct 2013

Combination of heat, doxorubicin drug and nanotech system may improve ovarian cancer treatment

The combination of heat, chemotherapeutic drugs and an innovative delivery system based on nanotechnology may significantly improve the treatment of ovarian cancer while reducing side effects from toxic drugs, researchers at Oregon State University report in a new study.

18 Oct 2013

NEJM publishes Celgene’s Abraxane phase III study results

Published today in the New England Journal of Medicine, a phase III clinical trial of Abraxane (paclitaxel formulated as albumin-bound nanoparticles) in combination with gemcitabine in treatment-naive patients with metastatic pancreatic cancer demonstrated a statistically significant improvement in overall survival compared to patients receiving gemcitabine alone [(median of 8.5 vs. 6.7 months) (HR 0.72, P=0.000015)].

17 Oct 2013

Simple urine test uses nanotechnology to detect dangerous blood clotting

Life-threatening blood clots can form in anyone who sits on a plane for a long time, is confined to bed while recovering from surgery, or takes certain medications.

17 Oct 2013

Common catalyst cerium oxide opens door to nanochemistry for medicine

Scientists at Rice University are enhancing the natural antioxidant properties of an element found in a car's catalytic converter to make it useful for medical applications.

16 Oct 2013

Scientists develop new method to regenerate cartilage

Unlike our bones, the cartilage inside our joints is not vascularized (i.e., it has no blood vessels). This is one reason why cartilage does not heal well after an injury. In athletes in particular, joint injuries often result in cartilage degeneration and arthritis. The process is chronic and irreversible, and to this day, no effective treatment exists.

12 Oct 2013

New combinations of postoperative pain treatment decreased both pain and use of pain relievers

New combinations of postoperative pain treatment decreased both pain and the use of narcotic pain relievers according to two studies presented this week at the 2013 Clinical Congress of the American College of Surgeons.

9 Oct 2013

Researchers to develop effective mucosal vaccines based on cell-targeted nanoparticles

The Knut and Alice Wallenberg Foundation will give a little over SEK 16 million to the development of new, highly-efficient mucosal vaccines. The vaccines will be drinkable or given as a nasal spray. Professor Nils Lycke at MIVAC at the Sahlgrenska Academy will in cooperation with researchers at Chalmers University of Technology and Lund University, combine technologies to develop the next generation of effective mucosal vaccines based on immunomodulation and cell-targeted nanoparticles.

9 Oct 2013

MIT engineers develop nanoparticles that deliver cancer vaccines to lungs

Many viruses and bacteria infect humans through mucosal surfaces, such as those in the lungs, gastrointestinal tract and reproductive tract. To help fight these pathogens, scientists are working on vaccines that can establish a front line of defense at mucosal surfaces.

26 Sep 2013

Engineered nanomaterials inhalation negatively impacts gestational development in animal models

After a decade of rapidly growing industrial use, unimaginably tiny particles surround us everywhere, every day, in everything we do. Used in the manufacturing of cosmetics, clothing, paints, food, drug delivery systems and many other familiar products we all use daily, little is known about the effects these materials have on health.

25 Sep 2013

New research chair established to develop innovative strategies for Alzheimer's disease

On September 19, INRS director general Daniel Coderre and INRS-Institut Armand-Frappier Centre director Charles M. Dozois announced the creation of the Louise and André Charron Research Chair in Alzheimer's Disease.

23 Sep 2013

World’s first preclinical Magnetic Particle Imaging (MPI) system announced by Bruker

At the 2013 World Molecular Imaging Congress (WMIC, www.wmicmeeting.org), Bruker today announced the world’s first Magnetic Particle Imaging (MPI) system, an entirely new technology for preclinical imaging. The addition of MPI as a complementary preclinical imaging technique for disease studies, translational research and drug discovery, has significant potential in helping researchers gain new insights into disease processes at the organ, cellular and molecular level.

From Bruker BioSpin - NMR, EPR and Imaging 19 Sep 2013

SignaBlok's novel peptide inhibitor of TREM-1 suppresses cancer progression

SignaBlok, Inc., a Massachusetts-based biopharmaceutical company, today announced the successful in vivo proof of concept data that demonstrate that the company's novel mechanism-based, first-in-class peptide inhibitor of TREM-1 effectively suppresses cancer progression in mouse models of lung cancer and dramatically improves survival in septic mice.

18 Sep 2013

Elevated miR-200 boosts survival of lung, ovarian, renal, triple-negative breast cancer patients

A family of microRNAs (miR-200) blocks cancer progression and metastasis by stifling a tumor's ability to weave new blood vessels to support itself, researchers at The University of Texas MD Anderson Cancer Center report today in Nature Communications.

12 Sep 2013

Binghamton researcher hopes to give docs accurate way of determining patient's risk of heart attack

A Binghamton University researcher hopes to give doctors a more accurate way of determining a patient's risk of heart attack or stroke.

11 Sep 2013

Revolutionary new solar energy technology sanitizes medical and dental instruments

A revolutionary new solar energy technology that turns water into steam without boiling the entire container of water has become the basis for new devices to sanitize medical and dental instruments and human waste in developing countries, scientists said here today.

10 Sep 2013

Little STING could go long way in avoiding arthritis, type 1 diabetes, report researchers

A little STING could go a long way in helping treat or even avoid autoimmune diseases such as arthritis, type 1 diabetes and multiple sclerosis, researchers report.

10 Sep 2013

Nanoparticles News and Research

MIT researchers design stealth drug delivery system to attack TNBC cells

UMMS professor receives EUREKA grant to develop light activated nanoparticles for imaging brain tissue

"One-two punch" disables tumors' defenses

Nanopharmaceutical drug shows promise for cancers that resist antiangiogenic drugs

Combination of heat, doxorubicin drug and nanotech system may improve ovarian cancer treatment

NEJM publishes Celgene’s Abraxane phase III study results

Simple urine test uses nanotechnology to detect dangerous blood clotting

Common catalyst cerium oxide opens door to nanochemistry for medicine

Scientists develop new method to regenerate cartilage

New combinations of postoperative pain treatment decreased both pain and use of pain relievers

Researchers to develop effective mucosal vaccines based on cell-targeted nanoparticles

MIT engineers develop nanoparticles that deliver cancer vaccines to lungs

Engineered nanomaterials inhalation negatively impacts gestational development in animal models

New research chair established to develop innovative strategies for Alzheimer's disease

World’s first preclinical Magnetic Particle Imaging (MPI) system announced by Bruker

SignaBlok's novel peptide inhibitor of TREM-1 suppresses cancer progression

Elevated miR-200 boosts survival of lung, ovarian, renal, triple-negative breast cancer patients

Binghamton researcher hopes to give docs accurate way of determining patient's risk of heart attack

Revolutionary new solar energy technology sanitizes medical and dental instruments

Little STING could go long way in avoiding arthritis, type 1 diabetes, report researchers

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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