Necroptosis News and Research

RSS

Targeting necroptosis using a necroptosis inhibitor lessens myositis-induced muscle weakness

A new study has suggested that treatment to target necroptosis in muscle fibers using a necroptosis inhibitor lessens myositis-induced muscle weakness as well as muscle cell death and inflammation in the muscles. This has been shown to be a promising strategy for treating polymyositis.

2 Mar 2022

Study identifies a protein complex critical for regulating apoptosis and necroptosis

Cell death plays an important role in normal human development and health but requires tightly orchestrated balance to avert disease. Too much can trigger a massive inflammatory immune response that damages tissues and organs. Not enough can interfere with the body's ability to fight infection or lead to cancer.

18 Feb 2022

Relationship between SARS-CoV-2 neurotropism and Alzheimer's disease

In a new study, researchers evaluated the neurotropism of SARS-CoV-2 and its impact on COVID-19 patients with and without neurological disorders like Alzheimer's disease.

3 Feb 2022

Early-stage alveolar epithelial cell necrosis linked to COVID-19-induced acute respiratory distress syndrome

A new study analyzed whether alveolar epithelial cell necrosis at an early stage SARS-CoV-2 infection and subsequent releases of damage-associated molecular patterns could aggravate COVID-19-associated acute respiratory distress syndrome.

27 Jan 2022

Review highlights oncolytic viruses with remarkable ability to destroy cancer cells

With the world still in the grip of a devastating pandemic, it's hard to imagine viruses as something other than hostile enemies to be vanquished.

30 Nov 2021

Mtb's exotoxin secretion and trafficking mechanism revealed

Six years ago, Michael Niederweis, Ph.D., described the first known toxin of the deadly pathogen Mycobacterium tuberculosis (Mtb), an exotoxin that had gone undetected for 132 years.

25 Nov 2021

Does SARS-CoV-2 infection contribute to adrenal gland dysfunction?

New research suggests that SARS-CoV-2 infection can directly target and cause cellular damage to the adrenal glands.

23 Nov 2021

The role of ZBP1 in promoting SARS-CoV-2-induced cytokine expression

A new study reported that the ZBP1-induced inflammatory signaling pathway is dependent on ubiquitination and RIPK3’s scaffolding ability, independent of cell death.

5 Oct 2021

Study identifies how immune sensors launch a multi-faceted innate immune response to infections

St. Jude Children's Research Hospital immunologists have identified how immune sensors in infected cells organize and launch a multi-faceted innate immune response to infections with live viruses and bacteria. The discovery appears today in Nature.

2 Sep 2021

Enzyme inhibitor boosts immune system to fight MRSA and other dangerous skin infections

In what turned out to be one of the most important accidents of all time, Scottish bacteriologist Alexander Fleming returned to his laboratory after a vacation in 1928 to find a clear zone surrounding a piece of mold that had infiltrated a petri dish full of Staphylococcus aureus (S. aureus), a common skin bacterium he was growing.

8 Jul 2021

Inhibiting necroptosis could be a novel approach for treating COPD

Research shows that inhibiting necroptosis, a form of cell death, could be a novel therapeutic approach for treating chronic obstructive pulmonary disease, an inflammatory lung condition, also known as emphysema, that makes it difficult to breathe.

17 Jun 2021

Research looks at inflammatory nature of lipid nanoparticle component in mRNA vaccines

In a recent bioRxiv preprint research paper, Botond Z. Igyártó and colleagues from Thomas Jefferson University demonstrated the inflammatory nature of the lipid nanoparticles (LNPs).

15 Mar 2021

Research provides deeper insight into the pathogenesis of sclerodermatous chronic GVHD

Occasionally, following a transplant procedure, the donor's immune cells recognize the recipient's tissues as foreign and trigger a multisystem disorder called graft-versus-host disease (GVHD).

2 Dec 2020

Study unravels the immunogenicity of ferroptotic cancer cells

The interdisciplinary team of scientists from three different countries (Belgium, Italy, and Russia) under the leadership of Prof. Dr. Dmitri V. Krysko (Ghent University, Belgium) unravels the immunogenicity of ferroptotic cancer cells.

25 Nov 2020

Scientists discover potential strategy to prevent inflammation in COVID-19 patients

The COVID-19 pandemic continues to cause significant illness and death while treatment options remain limited. St. Jude Children's Research Hospital scientists have discovered a potential strategy to prevent life-threatening inflammation, lung damage and organ failure in patients with COVID-19. The research appeared online in the journal Cell.

19 Nov 2020

Multiple, intertwined cell death systems to prevent the spread of 'intracellular' bacteria

Melbourne researchers have revealed the multiple, intertwined cell death systems that prevent the spread of the 'intracellular' bacterium Salmonella, an important cause of typhoid fever which kills more than 100,000 people annually.

30 Jul 2020

Research team shines new light on inflammatory cell death regulator

Walter and Eliza Hall Institute researchers have made significant advances in understanding the inflammatory cell death regulatory protein MLKL and its role in disease.

19 Jun 2020

Scientists unravel a new mechanism that triggers cell death and inflammation

Z-form nucleic acids are double-stranded DNA and RNA molecules with an unusual left-handed double helix structure, as opposed to the classical right-handed Watson-Crick double helix. Z-nucleic acids were discovered more than 40 years ago, but their biological function has remained poorly understood.

31 Mar 2020

Immunologists discover new RIPK1 mechanism that leads to cell death

Scientists at St. Jude Children's Research Hospital have discovered a new way that the molecule RIPK1 leads to cell death in infected, damaged or unwanted cells showing that more than one mechanism can trigger the process.

23 Dec 2019

Enzyme caspase-8 controls apoptosis, necroptosis and pyroptosis

The enzyme caspase-8 induces a molecular cell death programme called pyroptosis without involving its enzymatic activity, a new study by Hamid Kashkar published in Nature shows.

26 Nov 2019