Necroptosis News and Research

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TUM scientists discover molecular signaling pathway for self-destruction in leukemia cells

When adults develop blood cancer, they are frequently diagnosed with what is referred to as acute myeloid leukemia.

15 Jul 2016

Study shows cancer cell death via necroptosis can drive pancreatic tumor growth

The most aggressive form of pancreatic cancer - often described as one of the hardest malignancies to diagnose and treat -- thrives in the presence of neighboring tumor cells undergoing a particular form of "orchestrated cell death." This is according to a major study recently published in the journal Nature.

25 Apr 2016

Better understanding of cell death mechanism could lead to more efficient cancer immunotherapy

Researchers in the group of Prof. Dr. Peter Vandenabeele show that killed tumour cells can serve as a potent vaccine that stimulates the immune system to prevent the outgrowth of cancer cells.

2 Apr 2016

LMU researchers reveal how crystalline deposits induce cell death

Crystal formation plays a defining role in the pathogenesis of a range of common diseases, such as gout and atherosclerosis. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers led by Hans-Joachim Anders have now elucidated how the insoluble deposits induce cell death.

29 Jan 2016

TSRI scientists discover new role for enzyme involved in cell death

Scientists at The Scripps Research Institute have discovered a new role for an enzyme involved in cell death. Their study shows how the enzyme, called RIPK3, relays signals between the cell’s mitochondria “powerhouses” and the immune system.

22 Sep 2015

Scientists identify white blood cells that tumors use to suppress disease-fighting immune system

A study led by St. Jude Children's Research Hospital scientists has identified the population of white blood cells that tumors use to enhance growth and suppress the disease-fighting immune system.

19 Dec 2014

Abnormal activation of cell death pathways may lead to inflammatory skin diseases

Inflammatory skin diseases such as psoriasis may result from abnormal activation of cell death pathways previously believed to suppress inflammation, a surprise finding that could help to develop new ways of treating these diseases.

3 Dec 2014

Study reveals molecular mechanism of cell death

Researchers at VIB and Ghent University have unraveled the mechanism of necroptosis. This is a type of cell death that plays a crucial role in numerous diseases, from viral infections and loss of auditory nerve cells to multiple sclerosis, acute heart failure and organ transplantation.

5 Jun 2014

Researchers resolve long-standing mystery of enzyme's role in cell survival

St. Jude Children's Research Hospital solves mystery of enzyme's role in cell survival, offering clues of how immune system fights infection and possible strategies to treat problems ranging from heart attack to cancer.

23 May 2014

Melbourne researchers find link between necroptosis and inflammatory disease

A team of Melbourne researchers has shown a recently discovered type of cell death called necroptosis could be the underlying cause of inflammatory disease.

13 May 2014

Researchers examine how toxin triggers motor neuron death

In most cases of amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, a toxin released by cells that normally nurture neurons in the brain and spinal cord can trigger loss of the nerve cells affected in the disease, Columbia researchers reported today in the online edition of the journal Neuron.

7 Feb 2014

Scientists reveal structure of protein essential for triggering necroptosis

Scientists in Melbourne, Australia, have revealed the structure of a protein that is essential for triggering a form of programmed cell death called necroptosis, making possible the development of new drugs to treat chronic inflammatory diseases such as Crohn's disease and rheumatoid arthritis.

6 Sep 2013

Research findings could lead to new therapeutic approaches for liver cancer

Liver cancer (Hepatocellular Carcinoma, HCC) usually arises as the result of a chronic, inflammatory liver disease. The most common causes here are excessive alcohol consumption as well as a high-fat diet and also chronic infection with the hepatitis viruses B and C. In the course of the inflammatory process, the liver cells (hepatocytes) die more frequently due to programmed cell death.

30 Aug 2013

New studies in mice support toxic role of aluminum in neurodegenerative conditions

Investigators have linked aluminum accumulation in the brain as a possible contributing factor to neurodegenerative disorders such as Alzheimer's disease. A new study published in Restorative Neurology and Neuroscience sheds light on the mechanism underlying aluminum-induced neuronal cell death and identifies necrostatin-1 as a substance which counteracts several of aluminum's neurotoxic effects.

6 Aug 2013

Necrostatin-1: A substance which counteracts several of aluminum's neurotoxic effects

New Studies in Mice Support Toxic Role of Aluminum in Neurodegenerative Conditions, According to Report in Restorative Neurology and Neuroscience

3 Aug 2013

New approach may prevent septic shock

Researchers of VIB and UGent have discovered a new approach to preventing septic shock, an often fatal extreme inflammatory reaction of the body. It is the most frequent cause of death at intensive care departments in hospitals.

28 Dec 2011

Inhibition of necroptosis protects mice from lethal SIRS

Sepsis, a form of systemic inflammation, is the leading cause of death in critically ill patients. Sepsis is linked with massive cell death; however, the specific mechanisms involved in the lethality of sepsis are unclear. Now, a new study published by Cell Press in the December 23rd issue of the journal Immunity finds that inhibition of a specific cell death pathway called "necroptosis" protected mice from lethal inflammation.

23 Dec 2011

Stopping necroptosis in keratinocytes prevents skin inflammation

The outer layer of the skin, called the epidermis, forms a critical physical and immunological wall that serves as the body's first line of defense against potentially harmful microorganisms. Most of the epidermis consists of cells called keratinocytes that build a mechanical barrier but also perform immune functions.

14 Oct 2011

Stopping unwanted cell death: novel avenue for drug development

Research published in Nature Chemical Biology reveals that three specific inhibitors of a cell death pathway, termed necroptosis, all target and inhibit RIP1 kinase, a protein that can direct cells into necrosis.

13 Apr 2008