Necrosis News and Research

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Atlas of cancer's hidden rules: Unveiling the transcriptomic and epigenetic secrets across 11 tumors

Researchers have mapped the complex epigenetic and transcriptomic landscape of cancer, revealing key regulatory elements across 11 tumor types that could unlock new insights into cancer progression and metastasis.

5 Nov 2023

Using ripretinib and surgery to manage recurrent gastrointestinal stromal tumor

A new case report was published in Oncoscience (Volume 10) on September 20, 2023, entitled, "Multi-disciplinary management of recurrent gastrointestinal stromal tumor harboring KIT exon 11 mutation with the switch-control kinase inhibitor ripretinib and surgery."

3 Nov 2023

AI model calculates percent necrosis in osteosarcoma patients with 99% accuracy

A research team at Johns Hopkins Medicine has created and trained a machine learning model to calculate percent necrosis (PN) -; or, what percentage of a tumor is "dead" and no longer active -; in patients with osteosarcoma, a type of bone cancer.

3 Nov 2023

Mast cell receptor linked to alcohol withdrawal-associated headaches

Researchers investigate the role of the mast-cell-specific receptor Mas-related G-protein-coupled receptor B2 (MrgprB2) in alcohol-withdrawal-induced headaches.

2 Nov 2023

Expert consensus on the classification of acute atherothrombotic myocardial infarction by stage of tissue injury severity

A document published in the Canadian Journal of Cardiology outlines the Canadian Cardiovascular Society's classification of acute MI.

1 Nov 2023

A four-stage classification of heart attack based on heart muscle damage

Heart attacks, or acute myocardial infarction (MI), are one of the leading causes of death worldwide. The newly released Canadian Cardiovascular Society Classification of Acute Myocardial Infarction (CCS-AMI) appearing in the Canadian Journal of Cardiology, published by Elsevier, presents a four-stage classification of heart attack based on heart muscle damage.

31 Oct 2023

Canadian Cardiovascular Society releases new heart attack classification based on heart tissue damage

The Canadian Cardiovascular Society (CCS) released the world's first classification of acute myocardial infarction (AMI), or heart attack, based on heart tissue damage research that was driven by two cardiovascular investigators within the Ischemic Heart Disease Program of Krannert Cardiovascular Research Center (KCVRC) at Indiana University School of Medicine and Northern Ontario School of Medicine.

30 Oct 2023

NF-κB activation during COVID-19 and its impact on patients with hypertension

Researchers review the role of NF-κB activation in the replication of SARS-CoV-2 and the impact of COVID-19 medications on NF-κB activation.

25 Oct 2023

Red grape polyphenol, resveratrol: a multifaceted therapeutic powerhouse under review

The therapeutic potential of resveratrol, a red grape polyphenol.

25 Oct 2023

Neoadjuvant pembrolizumab achieves major pathologic response in more than half of patients with resectable melanoma

In exploratory analyses of results from the SWOG S1801 trial in patients with stage III-IV resectable melanoma, researchers saw a major pathologic response in more than half of surgical specimens taken from patients who had been treated with neoadjuvant (pre-operative) pembrolizumab.

24 Oct 2023

Is COVID-19 a risk factor for Alzheimer's disease?

The study explores the interconnected risks between COVID-19 and Alzheimer's Disease (AD), highlighting how SARS-CoV-2 can aggravate AD pathology through neuroinflammation and neurodegeneration. It raises significant concerns about the long-term cognitive implications of COVID-19, especially among those already at risk for AD.

23 Oct 2023

How the gut microbiome contributes to schizophrenia

Researchers explore potential relationships between schizophrenia, the gut microbiome, the gut-brain axis, and short-chain fatty acids.

19 Oct 2023

How African sleeping sickness melts away body fat: New study sheds light on the role of lipolysis

Researchers find that the T. brucei parasite, responsible for African trypanosomiasis, triggers weight loss by disrupting fat cell lipolysis. The study shows that ATGL enzyme is key to this process, potentially offering a new angle for future research and treatment.

17 Oct 2023

UTHealth Houston clinical trial therapy shrinks tumor of pancreatic cancer patient

Demetrios Stroubakis, 55, thought he was having a gallbladder attack when he arrived at the emergency room in August 2021 with jaundice. Instead, he was shocked to be diagnosed with pancreatic cancer.

13 Oct 2023

Rare ‘flesh-eating’ bacterium spreads North as oceans warm

Debbie King barely gave it a second thought when she scraped her right shin climbing onto her friend's pontoon for a day of boating in the Gulf of Mexico on Aug. 13.

13 Oct 2023

Are migraines linked to gut health and chronic non-communicable diseases?

The Links Between Migraines, Gut Health, and Chronic Non-Communicable Diseases (CNCDs).

13 Oct 2023

Cracking the code: recent discoveries transform our understanding of cancer-immunity cycle

In a recent review published in Immunity, researchers reviewed tumor-immunity cycle data.

13 Oct 2023

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

The research paper explores the multifaceted role of the IL-17 family in immune response, covering everything from infection control to pathological conditions like autoimmune diseases and cancer. Future therapies may exploit IL-17's unique signaling pathways to offer more targeted and cost-effective treatments.

12 Oct 2023

Might a polyphenol-rich dietary approach hold the answers for managing inflammatory bowel disease?

Gut microbiota and macrophage-neutrophil interactions in the impact of dietary phenolic acids on intestinal inflammation.

11 Oct 2023

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

In the latest research published in Science Immunology, experts delve into the gene expression patterns of distinct intraepithelial lymphocyte populations in various gastrointestinal tract regions. Key findings reveal the roles of T-cell IELs in detecting infections and ensuring the gut's barrier integrity, with a special emphasis on their function in combating colon cancer.

9 Oct 2023

Necrosis News and Research

Atlas of cancer's hidden rules: Unveiling the transcriptomic and epigenetic secrets across 11 tumors

Using ripretinib and surgery to manage recurrent gastrointestinal stromal tumor

AI model calculates percent necrosis in osteosarcoma patients with 99% accuracy

Mast cell receptor linked to alcohol withdrawal-associated headaches

Expert consensus on the classification of acute atherothrombotic myocardial infarction by stage of tissue injury severity

A four-stage classification of heart attack based on heart muscle damage

Canadian Cardiovascular Society releases new heart attack classification based on heart tissue damage

NF-κB activation during COVID-19 and its impact on patients with hypertension

Red grape polyphenol, resveratrol: a multifaceted therapeutic powerhouse under review

Neoadjuvant pembrolizumab achieves major pathologic response in more than half of patients with resectable melanoma

Is COVID-19 a risk factor for Alzheimer's disease?

How the gut microbiome contributes to schizophrenia

How African sleeping sickness melts away body fat: New study sheds light on the role of lipolysis

UTHealth Houston clinical trial therapy shrinks tumor of pancreatic cancer patient

Rare ‘flesh-eating’ bacterium spreads North as oceans warm

Are migraines linked to gut health and chronic non-communicable diseases?

Cracking the code: recent discoveries transform our understanding of cancer-immunity cycle

IL-17: The molecule that could revolutionize autoimmune and cancer treatments

Might a polyphenol-rich dietary approach hold the answers for managing inflammatory bowel disease?

Gut defenders: How T-cell intraepithelial lymphocytes guard against colon cancer

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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