Nephrectomy News and Research

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Review of nephron sparing surgery for localized renal tumors

Nephron sparing surgery for localized renal tumors has gained increasing acceptance as a standard of care in appropriately selected patients.

21 Apr 2007

Hand-assisted radical nephrectomy study

Since the 1960's, radical nephrectomy through an open surgical approach has been the accepted standard of care for patients with localized and locally advanced renal cell carcinoma (RCC).

3 Apr 2007

Cryoablation for kidney tumor patients shows promise

Mayo Clinic researchers report that freezing kidney tumors through percutaneous cryoablation shows promise for patients who are not good candidates for surgery.

30 Mar 2007

New developments in the technique of partial nephrectomy

While partial nephrectomy has demonstrated oncologic equipoise with radical nephrectomy, it remains a surgically daunting procedure that can be associated with significant complications, particularly related to hemostasis and prevention of post-operative urinary fistulae.

1 Sep 2006

Laparoscopic partial nephrectomy using the potassium titnyl phosphate laser in a porcine model

Working with an 80 watt KTP laser delivered in a noncontact mode via a 600 micron fiber, these authors successfully completed 15 laparoscopic partial nephrectomies in pigs. This was done without clamping any renal vessels.

21 Aug 2006

A tissue marker of poor prognosis in clear cell renal cell carcinoma

The search for molecular markers that further advance our knowledge of the biology of renal cell carcinoma (RCC) and assist in evaluating the diagnosis and prognosis of patients remains the subject of intense investigation.

20 Aug 2006

Role of partial nephrectomy in the treatment of upper tract transitional cell carcinoma

Traditionally, upper tract transitional cell carcinoma (TCC) is managed with nephroureterectomy with excision of a bladder cuff.

22 May 2006

Renal cell carcinoma in the pediatric population

While the incidence of renal cell carcinoma (RCC) is rising, it remains a relatively uncommon malignancy in the pediatric population, where it represents only 2-6% of solid renal malignancies.

16 May 2006

The management of renal cell carcinoma in the elderly

The median age of presentation for patients with renal cell carcinoma (RCC) is in the 6th decade of life, but urologists are not uncommonly confronted with an elderly patient with a renal mass seeking treatment.

10 May 2006

What is the best laparoscopic approach for laparoscopic radical nephrectomy?

Laparoscopic radical nephrectomy is rapidly becoming the gold standard as the surgical procedure of choice in patients with localized renal cell carcinoma.

10 May 2006

Circulating tumor cells in the bone marrow of patients with metastatic renal cell carcinoma may be prognostic of outcome

Circulating tumor cells in the blood and bone marrow have been examined in a variety of malignancies, including colorectal, breast, and head & neck cancers, to determine their prognostic significance.

8 May 2006

Laparoscopic partial nephrectomy for centrally located renal tumors

The Cleveland Clinic Group has shown that with experience they have been able to effectively offer laparoscopic partial nephrectomy (LPN) to more patients with centrally located lesions.

17 Apr 2006

Underutilization of partial nephrectomy for localized renal cell carcinoma in the U.S.

In the past, the gold standard for the treatment of localized renal tumors has been radical nephrectomy. Over time however, experience with nephron sparing surgery and, now, laparoscopic approaches have demonstrated oncologic equipoise and may provide for an improved quality of life for patients as compared to those undergoing radical nephrectomy for localized renal masses.

31 Mar 2006

Partial nephrectomy: urologists need to practice what we preach

There is no question in the urologic literature that partial nephrectomy (PN), particularly for renal masses ¡Ü 4cm, has demonstrated oncologic equipoise with radical nephrectomy (RN).

14 Mar 2006

Renal and extrarenal predictors of nephrectomy from The National Trauma Data Bank reviewed

The management of renal trauma has become increasingly conservative with multiple series showing renal preservation after high grade injury.

13 Mar 2006

Therapy for metastatic renal cell carcinoma remains inadequate

The recent FDA approvals of the tyrosine kinase inhibitors sorafenib and sunitinib based on their activity in metastatic renal cell carcinoma have excited the medical oncology community

9 Mar 2006

Is partial nephrectomy oncologically safe for tumors greater than 4cm?

Traditionally, nephron sparing surgery in the presence of a normal contralateral kidney is primarily advocated for tumors <= 4cm.

7 Mar 2006

Most patients have kidney removed, despite organ-sparing surgery option

A less aggressive type of surgery designed to spare healthy organ tissue is used infrequently to treat early-stage kidney cancer, according to researchers at the University of Michigan Comprehensive Cancer Center.

21 Feb 2006

Imatinib mesylate (Gleevec) may not be effective at treating kidney cancer

Mayo Clinic Cancer Center investigators report that imatinib mesylate (GleevecTM), the drug used to treat patients with gastrointestinal stromal cancers (GISTs), is not likely to be effective for patients with high grade renal cell carcinoma -- the most aggressive kidney cancer.

22 Dec 2005

Open nephron-sparing surgery remains the most desirable for the patients

Urologists often view less-invasive surgery techniques as more desirable for the patient, but in a study of open nephron-sparing surgeries (NSS) from 1985 to 2001 at Mayo Clinic, researchers found that the "gold standard" of open surgery for kidney tumors should remain the first choice for many patients. The study appears online today in The Journal of Urology.

10 Aug 2005