Neuro oncology News and Research

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Surgical removal of tumor may boost survival of patients with brainstem high-grade gliomas

For adult patients with brainstem high-grade gliomas -- one of the rarest and deadliest forms of brain cancer -- surgically removing the entire tumor may add many months or potentially years of survival beyond that offered by radiation and chemotherapy, according to results of a medical records study led by researchers at the Johns Hopkins Kimmel Cancer Center.

From Johns Hopkins Medicine 9 Jan 2020

Scientists use novel technology for opening blood-brain barrier with implantable ultrasound

One of most potent drugs for treatment of glioblastoma, the most deadly type of brain tumor, can't be used in patients because of two problems. First, it can't reach its target because it's blocked by the blood-brain barrier, a microscopic structure that protects the brain from toxins in the blood. And the conventional formulation for this drug is toxic to the brain.

12 Dec 2019

Important biomarker may help in determining prognosis of brain cancer patients

A common virus that is harmless to most individuals may produce an important biomarker in determining the prognosis of brain cancer patients, according to a recent study published by a student researcher at the University of Cincinnati.

9 Dec 2019

Extra DNA scooped up alongside cancer-causing genes helps drive tumor growth

One of the ways a cancer-causing gene works up enough power to turn a normal cell into a cancer cell is by copying itself over and over, like a Xerox machine.

21 Nov 2019

Researchers identify compound effective in killing chemotherapy-resistant cancer cells

A compound effective in killing chemotherapy-resistant glioblastoma-initiating cells has been identified, raising hopes of producing drugs capable of eradicating refractory tumors with low toxicity.

18 Oct 2019

Roswell Park moving three-pronged immunotherapy strategy forward with support from DoD grant

A team from Roswell Park Comprehensive Cancer Center is moving a new three-part strategy for treating advanced cancers forward with support from a U.S. Department of Defense grant to Pawel Kalinski, MD, PhD, Vice Chair for Translational Research and Rustum Family Professor for Molecular Therapeutics and Translational Research at the Buffalo, N.Y.-based cancer center.

18 Sep 2019

Treatment with both targeted cancer therapy and MS drug halts glioblastoma stem cells

Glioblastoma is an aggressive form of brain cancer that infiltrates surrounding brain tissue, making it extremely difficult to treat with surgery.

9 Aug 2019

Chemotherapy drugs delivered using biodegradable paste can prolong survival in brain cancer

A combination of chemotherapy drugs during brain cancer surgery using a biodegradable paste, leads to long-term survival, researchers at the University of Nottingham have discovered.

18 Jul 2019

New approach could help in treating brain tumors, other rare cancers

Large randomized clinical trials can uncover biomarkers that indicate which cancer treatments are likely to work best for individual patients. But it's been challenging to find these biomarkers in rarer cancers where such robust data aren't available.

13 Jun 2019

Researchers propose a new look at the role of ferroptosis in cancer development

Professor of Ghent University and Lead Researcher at the Institute of Biology and Biomedicine of the Lobachevsky University Dmitri Krysko together with scientists from Germany, Professor Marcus Conrad and Professor Jose Pedro Friedmann Angeli recently published an article in the journal Nature Reviews Cancer, one of the highest-rated journals that occupies the 2nd line in the oncology section among 223 journals in this category and has an impact factor of 42.78 according to WoS data.

7 Jun 2019

Targeting immune cells could potentially treat some kinds of brain tumor, study suggests

Tumors arise when cells shake off their restraints and start to multiply out of control. But how fast a tumor grows does not depend solely on how quickly the cancer cells can divide, a new study has found.

4 Jun 2019

Cancer stem cells adapt to environmental conditions and undergo reversible transformations

Until now, researchers have assumed that the growth of solid tumors originates from cancer stem cells characterized by specific surface markers, which develop in a fixed, hierarchical order.

25 May 2019

Low-dose radiation therapy may increase uptake of therapeutic nanoparticles by brain tumors

A new study led by Massachusetts General Hospital (MGH) investigators finds that radiation therapy may increase the uptake of therapeutic nanoparticles by glioblastomas, raising the possibility of using both growth-factor-targeted and immune-system-based therapies against the deadly brain tumor.

28 Mar 2019

New combination treatment shows promise for common brain tumor in children

A new combination treatment aimed at resistant and recurrent low-grade gliomas slowed tumor growth and killed tumor cells in laboratory and mouse models.

22 Mar 2019

Immunotherapy drug can be effective in treating patients with recurrent brain tumors

A UCLA-led study suggests that for people with recurrent glioblastoma, administering an immunotherapy drug before surgery is more effective than using the drug afterward.

11 Feb 2019

£1.5 million awarded to brain tumor researchers to extend lab-based research into clinical trials

Brain tumors kill more people under the age of 40 than any other cancer and less than 20% of those diagnosed survive beyond five years, compared to 50% of all other cancers. New funding from Barts Charity will help researchers get closer to a cure.

11 Jan 2019

UA researchers discover promising lead in genetic approach to treating deadly brain cancer

Glioblastoma, a deadly brain cancer that has grabbed headlines for claiming the lives of Sens. Edward Kennedy and John McCain, could be "tricked" into sparing more of its victims.

30 Nov 2018

Microglia show distinct responses under inflammatory conditions

The NorLux Neuro-Oncology Laboratory at LIH's Department of Oncology conducts research on brain diseases, with a special emphasis on glioma biology, drug resistance and systems approaches.

26 Nov 2018

Special chemical that makes brain tumours glow pink to help neurosurgeons operate

A clinical trial has shown that a special chemical makes brain tumours glow pink. This can help neurosurgeons operate easily on them and remove them completely and safely say the researchers. The results of this study were presented at the 2018 NCRI Cancer Conference in Glasgow.

4 Nov 2018

Hippocampal-avoidance whole-brain radiotherapy better preserves patients' cognitive function

When it comes to radiation therapy to treat brain cancer, hippocampal-avoidance whole-brain radiotherapy in conjunction with the drug memantine better preserved patients' cognitive function and demonstrated similar cancer control outcomes, compared to traditional whole-brain radiotherapy with memantine.

24 Oct 2018