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Notable improvement in brain cancer survival among younger patients but not much for elderly

A new study from Helsinki University Hospital, University of Helsinki and the Finnish Cancer Registry shows that survival after glioblastoma has improved since the millennium. The improvement in survival was, however, modest in elderly patients, raising concerns whether current treatment strategies are optimal for this patient group.

16 Oct 2018

New blood test for pediatric brain tumor patients offers safer approach than surgical biopsies

A new blood test for children with brain tumors offers a safer approach than surgical biopsies and may allow doctors to measure the effectiveness of treatment even before changes are identified on scans, according to research led by UCSF Benioff Children’s Hospitals and Children’s National Health System.

16 Oct 2018

Olfactory cells could act as 'Trojan horse,' delivering anticancer therapy to dangerous brain tumors

A special type of cell essential to the ability of olfactory neurons to regenerate may be genetically engineered to deliver anticancer therapy to the dangerous brain tumors called glioblastomas.

27 Sep 2018

TGen and PNOC take part in launch of NIH-supported Kids First Data Resource Portal

As part of a national initiative to solve children's diseases, the Translational Genomics Research Institute and the Pacific Pediatric Neuro-Oncology Consortium are participating in the launch of the Kids First Data Resource Portal, which is supported by the National Institutes of Health .

19 Sep 2018

New clinical trial initiated on experimental vaccine to stop the spread of glioblastoma

Rush University Medical Center is part of a new clinical trial testing whether an experimental vaccine can help patients' immune systems stop the spread of glioblastoma -- an aggressive form of brain cancer with veryhttps://www.rush.edu/news/press-releases/rush-testing-new-brain-cancer-vaccine few current treatment options.

14 Sep 2018

Researchers uncover secret of immortality mechanism in aggressive glioblastoma

UC San Francisco researchers have discovered how a mutation in a gene regulator called the TERT promoter -- the third most common mutation among all human cancers and the most common mutation in the deadly brain cancer glioblastoma -- confers "immortality" on tumor cells, enabling the unchecked cell division that powers their aggressive growth.

10 Sep 2018

Novel approach reveals metabolic vulnerabilities in kidney cancer

In order to halt the growth of cancer cells, you have to know what feeds them. Researchers at the nationally recognized Kidney Cancer Program at UT Southwestern's Harold C. Simmons Comprehensive Cancer Center have developed a novel approach using glucose that may open up new opportunities for therapeutic intervention.

30 Aug 2018

Immunotherapies may increase overall survival in patients with melanoma brain metastases

Among patients with cutaneous melanoma who had brain metastases (MBM), first-line treatment with a checkpoint inhibitor was associated with a 1.4-fold increase in median overall survival, according to results from a national cohort.

13 Jul 2018

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

A Ludwig Cancer Research study explains why a particular mutation in the epidermal growth factor receptor, a cell surface protein, results in more aggressive tumors and poorer overall survival of patients diagnosed with the brain cancer glioblastoma multiforme.

10 Jul 2018

Viral immunotherapy shows promise to treat pediatric brain tumors

A viral immunotherapy using a herpes virus to treat brain tumors has been shown to be safe and well-tolerated in a pediatric study from the University of Alabama at Birmingham and Children's of Alabama.

4 Jul 2018

Researchers use MR spectroscopy to investigate mechanisms behind targeted treatment for gliomas

Using a novel imaging method, a Massachusetts General Hospital research team is investigating the mechanisms behind a potential targeted treatment for a subtype of the deadly brains tumors called gliomas.

21 May 2018

Two immune checkpoint inhibitors efficiently block leukemia development in preclinical tests

Chronic lymphocytic leukemia is a hematological malignancy that originates in the blood-forming cells of the bone marrow and spreads to other organs through the bloodstream.

17 Apr 2018

Study lays groundwork for using PD-1 inhibitors against aggressive form of pediatric brain cancer

One type of immunotherapy removes a genetic blindfold that cancer uses to hide from the immune system. These "PD-1 inhibitors", including drugs like pembrolizumab, nivolumab and atezolizumab, have proven useful and have even in some cases revolutionized the treatment of common adult cancers ranging from melanoma, to lung cancer, to kidney cancer and more.

30 Jan 2018

Combination chemotherapy increases survival in animal models of glioblastoma

A diagnosis of the brain cancer glioblastoma carries a dismal prognosis, with most patients dying within five years.

23 Jan 2018

Experts report new guidelines for clinical trial design in patients with brain metastases

Clinical trials of new anti-cancer therapies have often excluded patients whose disease has spread to the brain or central nervous system (CNS) or, if such patients were allowed on trial, trials have often failed to clearly capture information on the drug's effect in the brain.

30 Dec 2017

Certain brain tumor patients more likely to receive short hospice services, study finds

While more than 60 percent of patients with the brain tumors called malignant gliomas enroll in hospice services, almost a quarter of them do so within a week of death, probably too late for patients and family members to benefit from hospice care.

20 Dec 2017

New scalp device delivering electric fields improves survival in patients with glioblastoma

A device attached to a patient's scalp that delivers a continuous dose of low-intensity electric fields improves survival and slows the growth of a deadly brain tumor, according to a new clinical trial led by a Northwestern Medicine scientist and published Dec. 19 in the journal JAMA.

19 Dec 2017

Neuro oncology News and Research

Notable improvement in brain cancer survival among younger patients but not much for elderly

New blood test for pediatric brain tumor patients offers safer approach than surgical biopsies

Olfactory cells could act as 'Trojan horse,' delivering anticancer therapy to dangerous brain tumors

TGen and PNOC take part in launch of NIH-supported Kids First Data Resource Portal

New clinical trial initiated on experimental vaccine to stop the spread of glioblastoma

Researchers uncover secret of immortality mechanism in aggressive glioblastoma

Novel approach reveals metabolic vulnerabilities in kidney cancer

Immunotherapies may increase overall survival in patients with melanoma brain metastases

Ludwig-developed antibody drug for deadly brain cancer may have broader applications

Viral immunotherapy shows promise to treat pediatric brain tumors

Researchers use MR spectroscopy to investigate mechanisms behind targeted treatment for gliomas

Two immune checkpoint inhibitors efficiently block leukemia development in preclinical tests

Study lays groundwork for using PD-1 inhibitors against aggressive form of pediatric brain cancer

Combination chemotherapy increases survival in animal models of glioblastoma

Experts report new guidelines for clinical trial design in patients with brain metastases

Certain brain tumor patients more likely to receive short hospice services, study finds

New scalp device delivering electric fields improves survival in patients with glioblastoma

Study provides new insights into mechanism of tumor survival in glioblastoma

Study shows how interplay between two key enzymes promotes brain tumor growth

Innovative technique makes low-grade gliomas visible

Cancer Research eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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