Neurodegenerative Disease News and Research

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Alnylam and Medtronic announce pre-clinical research findings from their Huntington’s disease program

Alnylam Pharmaceuticals, Inc. (Nasdaq: ALNY), a leading RNAi therapeutics company, and Medtronic, Inc. (NYSE: MDT), the world’s leading developer of medical devices, announced today the presentation of new pre-clinical research findings from their Huntington’s disease program at the 2009 World Congress on Huntington’s Disease held September 12-15, 2009 in Vancouver, British Columbia.

15 Sep 2009

Mild cognitive impairment is a risk factor for dementia

Among individuals with mild cognitive impairment, often considered a transitional state between normal cognitive function and Alzheimer's dementia, those who have more difficulties performing routine activities appear more likely to progress quickly to dementia, according to a report in the September issue of Archives of Neurology, one of the JAMA/Archives journals.

15 Sep 2009

Parkinson Society Canada's SuperWalk raises record amount

SuperWalk for Parkinson's raised a record $2.46 million this year. Lauren Collins, star of Degrassi: The Next Generation, unveiled the new look SuperWalk for 2010 at this year's Toronto walk. Collins, left, walked with her mother, Sari, for her father who has had Parkinson's for over 20 years.

14 Sep 2009

Applications invited from scientists for LBD Biomarker Research Award

The Alzheimer's Drug Discovery Foundation (ADDF) and the Lewy Body Dementia Association (LBDA) invite scientists from the biotechnology industry and academia worldwide to apply for a new collaborative research grant award entitled Lewy Body Dementia Biomarker Research Award.

8 Sep 2009

Higher education levels associated with an earlier need for symptomatic treatment of Parkinson's disease

Individuals who have higher levels of education and who are more impaired by Parkinson's disease appear to require treatment for their symptoms earlier than do other patients, according to a report posted online today that will appear in the September print issue of Archives of Neurology, one of the JAMA/Archives journals.

2 Sep 2009

$3 million grant to help Parkinson's Institute and Clinical Center to continue cutting-edge research

The Parkinson's Institute and Clinical Center (PI) is very excited to announce the receipt of a $3 million challenge grant from the Brin Foundation as the lead gift in the PI's $15 million Capital Campaign - "A Campaign to Conquer Parkinson's Disease." The "Challenge" feature of the grant invites individuals, foundations and corporations to partner with the Brin Foundation in support of Parkinson's research.

28 Aug 2009

Mutations associated with prion diseases are sufficient to cause transmissible neurodegenerative disease

For the first time, Whitehead Institute researchers have shown definitively that mutations associated with prion diseases are sufficient to cause a transmissible neurodegenerative disease.

26 Aug 2009

Mesenchymal stem cells repair human brain

There is no known cure for neurodegenerative diseases such as Huntington's, Alzheimer's and Parkinson's. But new hope, in the form of stem cells created from the patient's own bone marrow, can be found ― and literally seen ― in laboratories at Tel Aviv University.

20 Aug 2009

Promising new treatment target for Kennedy's disease

New research with transgenic mice reveals that a therapy directed at the muscle significantly improves disease symptoms of a genetic disorder characterized by destruction of the neurons that control movement. The study, published by Cell Press in the August 13th issue of the journal Neuron, highlights a promising new treatment for this currently incurable and nontreatable neurodegenerative disorder.

12 Aug 2009

New class of molecules capable of blocking formation of tau protein fibrils

A new class of molecules capable of blocking the formation of specific protein clumps that are believed to contribute to Alzheimer’s disease pathology has been discovered by researchers at the University of Pennsylvania School of Medicine. By assaying close to 300,000 compounds, they have identified drug-like inhibitors of AD tau protein clumping, as reported in the journal Biochemistry.

11 Aug 2009

Scientists investigate health benefits of molecule associated with male sexual arousal

Medical scientists at the University of Leicester are investigating how signalling molecules known to control blood pressure and penile erection act to regulate brain function and which have potential for treatments of migraine, chronic pain, epilepsy and Alzheimer's disease.

24 Jun 2009

New discovery on Huntington's disease

Researchers at the University of Illinois at Chicago College of Medicine have discovered how the mutated huntingtin gene acts on the nervous system to create the devastation of Huntington's disease. The report of their findings is available in Nature Neuroscience online.

15 Jun 2009

Drugs designed to tackle endoplasmic reticulum stress might be useful in treating heart disease

Researchers say they have evidence to explain what separates your average blood vessel plaque from those that are at high risk for triggering the development of dangerous - even fatal - blood clots.

5 May 2009

Stem cell therapy used to fight amyotrophic lateral sclerosis

A team of Utahns is collaborating on a stem cell therapy to fight amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

21 Apr 2009

Neurodegeneration study reveals targets of destruction

Scientists are reporting the strongest evidence to date that neurodegenerative diseases target and progress along distinct neural networks that normally support healthy brain function.

15 Apr 2009

Scientists uncover mimicry at the molecular level that protects genome integrity

The new study, which was published on April 12, 2009, in an advanced online edition of the journal Nature Structural & Molecular Biology, draws new parallels between the Rad60 DNA repair factor and SUMO, a small ubiquitin-like modifier, which are both essential for maintaining genome stability during replication.

13 Apr 2009

New common pathway in neurodegenerative disease is a possible door to a point of no return

A just-out study suggests that what keeps chronic nervous system diseases such as Alzheimer's, Huntington's and ALS going - until they overcome the internal protective mechanisms a body can throw at them - may largely come down to poor conversational skills.

9 Apr 2009

Alzheimer's mechanism suggests combination therapy needed

Researchers at the University of Illinois at Chicago College of Medicine have discovered a mode of action for mysterious but diagnostic protein snarls found in the brains of Alzheimer's patients that suggests a one-two punch of therapy may be needed to combat the neurodegenerative disease.

17 Mar 2009

A living representation of the brain created by scientists

Researchers in the School of Life & Health Sciences at Aston University in Birmingham, UK are developing a novel new way to model how the human brain works by creating a living representation of the brain.