Neurodegenerative Diseases News and Research

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Novel PTP1B inhibitor drug candidate can prevent lethal lung inflammation in mice

Neutrophils, the most abundant type of white blood cell, are the body's first line of defense against infection. Foreign pathogens can stress the body and activate neutrophils.

23 Sep 2022

SARS-CoV-2 generates amyloid in cerebral spinal fluid

In a recent study posted to the bioRxiv* preprint server, an international team of researchers demonstrated amyloid aggregation due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human cerebrospinal fluid (CSF).

20 Sep 2022

Discovery could resolve one of the mysteries of Parkinson's disease

Aggregates of the protein alpha-synuclein spread in the brains of people with Parkinson's disease through a cellular waste-ejection process, suggests a new study led by Weill Cornell Medicine researchers.

20 Sep 2022

What are the effects of pesticides on neonates' health?

A new study explores the impact of pesticide exposure in neonates, reviewing current literature while evaluating the research methods used in this area.

20 Sep 2022

RIT scientist receives $1.7 million NIH award to study how cells control the size of organelles

A Rochester Institute of Technology scientist hopes that a better understanding of how living cells maintain the size of their organelles can lead to therapies for neurodegenerative diseases.

16 Sep 2022

Large molecules glom together into dense droplets to create squishy circuits in cells

An emerging field explores how groups of molecules condense together inside cells, the way oil droplets assemble and separate from water in a vinaigrette.

14 Sep 2022

C-Path secures FDA Grant for new public-private partnership to benefit people with rare neurodegenerative diseases

Critical Path Institute has announced it will serve as the convener of the Critical Path for Rare Neurodegenerative Diseases, a new public-private partnership to benefit people across multiple rare neurodegenerative diseases, supported by a grant from the U.S. Food and Drug Administration.

14 Sep 2022

Age-related changes in microbiome composition affects brain macrophages

Scientists review the impact of age-related gut microbiome composition on age-associated diseases caused by dysfunctional macrophages within the brain.

13 Sep 2022

Exercise hormone reduces protein levels linked to Parkinson's disease

Researchers from Johns Hopkins Medicine and the Dana Farber Cancer Institute in Boston have shown that a hormone secreted into the blood during endurance, or aerobic, exercise reduces levels of a protein linked to Parkinson's disease and halts movement problems in mice.

12 Sep 2022

Pollutant particles in the air trigger lung cancer in non-smokers

A new mechanism has been identified through which very small pollutant particles in the air may trigger lung cancer in people who have never smoked, paving the way to new prevention approaches and development of therapies, according to late-breaking data [to be] reported at the ESMO Congress 2022 by scientists of the Francis Crick Institute and University College London, funded by Cancer Research UK. The particles, which are typically found in vehicle exhaust and smoke from fossil fuels, are associated with non-small cell lung cancer (NSCLC) risk, accounting for over 250,000 lung cancer deaths globally per year.

12 Sep 2022

Molecular probes can track the progress of protein that misbehaves in neurodegenerative diseases

A team of researchers from the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has designed in silico "molecular probes" able to track the progress of a protein that misbehaves in different neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Dementia (FTD).

9 Sep 2022

New research project investigates molecular mechanisms underlying NeuroCOVID

Infections with the coronavirus SARS-CoV-2 can trigger both temporary and long-term neurological and neuropsychiatric symptoms, severely impacting patients and the wider society.

9 Sep 2022

Scientists reverse the effects of lysosomal storage disorders in patient cells and mice

Scientists at the Icahn School of Medicine at Mount Sinai in New York, the National Center for Advancing Translational Sciences (NCATS), and elsewhere have reversed the effects of several life-threatening inherited neurodegenerative diseases called lysosomal storage disorders (LSDs) in patient cells and mice.

9 Sep 2022

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

A new University of California, Irvine-led study reveals how mechanical forces and tissue mechanics influence the morphology of the developing brain, and establishes a direct link in neural stem cells between Piezo1, a mechanically-activated ion channel, and intracellular cholesterol levels during neural development.

8 Sep 2022

Neurodegenerative Diseases News and Research

Novel PTP1B inhibitor drug candidate can prevent lethal lung inflammation in mice

SARS-CoV-2 generates amyloid in cerebral spinal fluid

Discovery could resolve one of the mysteries of Parkinson's disease

What are the effects of pesticides on neonates' health?

RIT scientist receives $1.7 million NIH award to study how cells control the size of organelles

Large molecules glom together into dense droplets to create squishy circuits in cells

C-Path secures FDA Grant for new public-private partnership to benefit people with rare neurodegenerative diseases

Age-related changes in microbiome composition affects brain macrophages

Exercise hormone reduces protein levels linked to Parkinson's disease

Pollutant particles in the air trigger lung cancer in non-smokers

Molecular probes can track the progress of protein that misbehaves in neurodegenerative diseases

New research project investigates molecular mechanisms underlying NeuroCOVID

Scientists reverse the effects of lysosomal storage disorders in patient cells and mice

Study establishes link between Piezo1 and intracellular cholesterol levels during neural development

The role of nasal microbiome in Parkinson's disease

Researchers secure $20.5 million NIH grant to beat Alzheimer's disease and related dementias

Simple blood test may identify patients at high risk of neurotoxic complications after CAR-T cell therapy

Scientists uncover how a build-up of harmful protein starts to happen in Parkinson's disease

In vivo imaging of α-synuclein aggregates in the brains of living patients with multiple system atrophy

Researchers identify potential new pathway for treating a sporadic form of ALS

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