Neurogenesis News and Research

RSS

Neurogenesis (birth of neurons) is the process by which neurons are generated. Most active during pre-natal development, neurogenesis is responsible for populating the growing brain.

Trinity researchers reveal CHD5 protein acts as tumor suppressor in nervous system development

CHD5 has previously been proposed as a tumour suppressor, acting as a brake that prevents healthy cells from developing into cancer cells. But the part played by the protein in healthy tissue, and whether this role is important for its ability to counter tumour growth, has remained largely uncharted.

14 Aug 2013

Computerized cognitive testing plays a key role in therapy development for dementia, AD

Computerized cognitive testing is increasingly playing a key role in therapy development for dementia and Alzheimer's disease. This week at the Alzheimer's Association International Conference, Keith Wesnes Ph.D., Practice Leader of Bracket and founder of the CDR System-, discussed new data for novel therapies at two poster presentations at the Alzheimer's Association International Conference.

19 Jul 2013

Study explores mechanisms of chemotherapy-induced neurological side effects

Chemotherapy is one of the primary treatments for cancer. However, one of the most disturbing findings of recent studies of cancer survivors is the apparent prevalence of chemotherapy-associated adverse neurological effects, including vascular complications, seizures, mood disorders, cognitive dysfunctions, and peripheral neuropathies.

16 Jul 2013

Scientists focus on the role of mutated adult neural stem cells play in human diseases

CHARGE syndrome* is a severe developmental disorder affecting multiple organs. It affects 1 in 8500 newborns worldwide. The majority of patients carry a mutation in a gene called CHD7. How this single mutation leads to the broad spectrum of characteristic CHARGE symptoms has been a mystery.

6 Jul 2013

Study shows possible biological cause of narcolepsy

In 2000, researchers at the UCLA Center for Sleep Research published findings showing that people suffering from narcolepsy, a disorder characterized by uncontrollable periods of deep sleep, had 90 percent fewer neurons containing the neuropeptide hypocretin in their brains than healthy people.

4 Jul 2013

Researchers mobilize brain's native stem cells to replenish neuron lost in Huntington's disease

Researchers have been able to mobilize the brain's native stem cells to replenish a type of neuron lost in Huntington's disease.

7 Jun 2013

Research shows fish oils could minimize effects of junk food on brain

Data from more than 180 research papers suggests fish oils could minimise the effects that junk food can have on the brain, a review by researchers at the University of Liverpool has shown.

15 May 2013

Findings could help develop new approaches to treat depression and memory loss in the elderly

Scientists have known for some time that exercise induces neurogenesis in a specific brain region, the hippocampus. However, until this study, the underlying mechanism was not fully understood.

14 May 2013

Hypothalamus controls aging throughout the body, scientists report

While the search continues for the Fountain of Youth, researchers may have found the body's "fountain of aging": the brain region known as the hypothalamus.

2 May 2013

Neuralstem gets approval from FDA for dosing cohort patients in NSI-189 Phase Ib in MDD treatment

Neuralstem, Inc. announced that it has received approval from the Food and Drug Administration (FDA) to begin dosing the third and final cohort of patients in its ongoing Phase Ib to test the safety of NSI-189 in the treatment of major depressive disorder (MDD).

26 Apr 2013

Reduction in neurogenesis associated with loss of certain cognitive faculties

These results incentivise the development of targeted therapies enabling improved neurone production to alleviate cognitive decline in the elderly and reduce the cerebral lesions caused by radiotherapy.

11 Apr 2013

New born neurons as a therapeutic strategy: an interview with Mi-Hyeon Jang, Mayo Clinic in Rochester, Minnesota

There are two regions in the brain that continue to produce new neurons well into adulthood. One of these regions is the hippocampus and as we converse this region is actively involved in memory formation, mood regulation and cognition.

2 Apr 2013

Environmental enrichment increases endogenous cell migration, facilitates functional repair

A team of Korean researchers investigated whether "environmental enrichment" can improve the neurobehavioral function of six week-old mice after transplantation of adipose-derived stem cells to treat hypoxic-ischemic brain injury, and found that brain repair (neurogenesis) was aided in some animals through exercise-induced fibroblast growth factor 2 (FGF2), a strong pro-angiogenic factor.

28 Mar 2013

Combination of HUCBCs and Simvastatin offers promising therapy for stroke: Study

Researchers at the Henry Ford Health System (Detroit, MI) and colleagues at Saneron CCEL Therapeutics, Inc. of Tampa, Florida, have found that when human umbilical cord blood cells were transplanted into test rats modeled with stroke, the addition of Simvastatin to the HUCBCs significantly increased the therapeutic benefit of the HUCBCs.

21 Mar 2013

Selective activation of the dentate gyrus can reduce anxiety without affecting learning

Columbia University Medical Center (CUMC) researchers have found the first evidence that selective activation of the dentate gyrus, a portion of the hippocampus, can reduce anxiety without affecting learning.

7 Mar 2013

EpiCept fourth quarter revenue decreases to $0.1 million

EpiCept Corporation today announced operating and financial results for the fourth quarter and full year ended December 31, 2012, and provided an update on the Company's merger with Immune Pharmaceuticals, Ltd. (Immune).

28 Feb 2013

Loss of Dickopf-1 restores neurogenesis and memory in animal model

Loss of the molecule Dickopf-1 in the hippocampus in older animals increases neurogenesis, research shows.

26 Feb 2013

New research offers clues for chemotherapy-induced cognitive impairment

It's not unusual for cancer patients being treated with chemotherapy to complain about not being able to think clearly, connect thoughts or concentrate on daily tasks. The complaint - often referred to as chemo-brain - is common. The scientific cause, however, has been difficult to pinpoint.

22 Feb 2013

Brain health just as important as physical health

We all know the importance of keeping healthy and are familiar with the refrains of 'exercise more', 'eat better' and 'get regular physicals'. But what about our mental health? Professor Barbara Sahakian, best known for her expertise on cognitive enhancers, challenges society (and government) to prioritise mental health in the same way as we do physical health.

17 Feb 2013

Prions may be crucial in brain development during childhood

A molecule that is not only dangerous, but can help the brain grow. A few years ago it was found that certain proteins, the prions, when defective are dangerous, as they are involved in neurodegenerative syndromes such as the Creutzfeldt-Jakob and the Alzheimer diseases.

16 Feb 2013