Neurological Disease News and Research

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Parkinson’s disease linked to genetic alteration of immune system: Study

Parkinson’s disease (PD), a severely crippling disease of the nerves and brain has been linked to genes that affect the immune system according to new research. In these patients the immune system may go awry attacking healthy tissues or failing to fight infections that leave people susceptible to the condition scientists say.

16 Aug 2010

Scientists replace human gene to preserve photoreceptor function in retinal degeneration

The easy accessibility of the eye and the established link between specific genetic defects and ocular disorders offer hope for using gene therapy to provide long-term therapeutic benefit. Two reports in the current issue of Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc., describe the effective replacement of a human gene to preserve photoreceptor function in a mouse model of severe retinal degeneration. The articles are available free online.

16 Aug 2010

Common genetic variation in HLA region associated with late-onset sporadic Parkinson's disease: Research

A team of researchers has discovered new evidence that Parkinson's disease may have an infectious or autoimmune origin. "Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease" appears online in Nature Genetics.

16 Aug 2010

Spinal muscular atrophy may lead to cardiac dysfunction: Study

Along with skeletal muscles, it may be important to monitor heart function in patients with spinal muscular atrophy (SMA). These are the findings from a study conducted by Nationwide Children's Hospital and published online ahead of print in Human Molecular Genetics. This is the first study to report cardiac dysfunction in mouse models of SMA.

11 Aug 2010

Alzheimer’s disease can now be predicted with 100% accuracy: Study

In a new development, Alzheimer's disease can now be predicted with up to 100 percent accuracy several years before its onset using three special marker proteins present in the spinal fluids. The study was published in the American Medical Association's Archives of Neurology.

9 Aug 2010

Scientists find new way to make beating heart cells from body's own cells

Scientists at the Gladstone Institute of Cardiovascular Disease have found a new way to make beating heart cells from the body's own cells that could help regenerate damaged hearts. Over 5 million Americans suffer from heart failure because the heart has virtually no ability to repair itself after a heart attack.

6 Aug 2010

Detection of Alzheimer's before symptoms occur

Research is on to detect the dreaded Alzheimer's disease even before any symptoms occur. In a newly proposed diagnostic criteria developed by experts from the National Institute on Aging and the Alzheimer's Association three stages of the disease viz. pre-clinical Alzheimer's, mild cognitive impairment and Alzheimer's dementia are described.

4 Aug 2010

FDA accepts for filing Cladribine Tablets NDA for MS

EMD Serono, Inc., an affiliate of Merck KGaA, Darmstadt, Germany, announced today that the U.S. Food and Drug Administration (FDA) has accepted for filing the New Drug Application (NDA) for Cladribine Tablets as a therapy for relapsing forms of multiple sclerosis (MS).

28 Jul 2010

Major breakthrough in Alzheimer's disease research

Researchers from the University of Sydney's Alzheimer's and Parkinson's Disease Laboratory have achieved a major breakthrough by finding the causes of Alzheimer's disease at a cellular level and thereby identifying a potential therapy as a result.

23 Jul 2010

BDSRA designates Nationwide Children's Hospital as Batten Disease Center of Excellence

Nationwide Children's Hospital has been selected as a Center of Excellence by the Batten Disease Support and Research Association (BDSRA), the largest research and support organization in North America for families that have children with Batten disease. BDSRA chose Nationwide Children's because of its clinical and research history with the disease and its ability to provide comprehensive care for these unique children.

23 Jul 2010

Gladstone Institutes, H. Lundbeck collaborate to identify therapeutic candidates for neurological diseases

The Gladstone Institutes and the international pharmaceutical company H. Lundbeck A/S have announced a collaborative research agreement to study and identify therapeutic candidates for neurological diseases. The agreement funds research at the Gladstone Center for Translational Research led by Gladstone investigator Katerina Akassoglou, PhD, and establishes the new Lundbeck Center for Neurovascular and Immuno-imaging at the Gladstone Institute of Neurological Disease.

22 Jul 2010

Improved delivery methods needed to advance gene therapy strategies for prostate cancer: Review

Improved delivery methods and better testing systems are needed to advance promising gene therapy strategies for treating prostate cancer, according to a series of review articles in Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc.

14 Jul 2010

Larger heads may protect against Alzheimer’s disease: Study

A larger head may be offer natural protection against dementia and Alzheimer’s disease say researchers in a study conducted on 270 patients and published in the journal Neurology.

13 Jul 2010

MRC Technology, Genentech sign licensing agreement

MRC Technology (UK) announced today that it has entered into an agreement with Genentech, Inc., a wholly owned member of the Roche Group for an exclusive licence to a series of small molecule drug candidates for the potential treatment of neurological disease.

12 Jul 2010

Scientists identify new strategy for treating movement disorders

Scientists at the Gladstone Institute of Neurological Disease and Stanford University have shown how key circuits in the brain control movement. The research, published in the journal Nature not only establishes the function of these circuits, but offers promise for treating movement related disorders, such as Parkinson's disease.

8 Jul 2010

Brain fever mistaken as migraine kills a 30 year old woman

Jane Harrop, a 30 year old British woman was complaining of headaches for several days that made her feel “drunk”. She was diagnosed to be suffering from migraine but died two days later from a viral infection of the brain.

7 Jul 2010

Depression and dementia may go hand in hand: Study

A new study has found that depressive disorders raise the risk of dementia. The findings of this study were published in the journal Neurology. The study involved nearly 1,000 people who were studied for up to 17 years. Those who were depressed when first examined almost doubled their risk for dementia and also increased their risk for Alzheimer's disease the study authors wrote.

5 Jul 2010

Researchers to study interventional endovascular therapy on symptoms and progression of MS

Buffalo medical researchers led by a team from the University at Buffalo Department of Neurosurgery, will embark on a landmark prospective randomized double-blinded study to test the safety and efficacy of interventional endovascular therapy -- dubbed "liberation treatment" -- on the symptoms and progression of Multiple Sclerosis.

1 Jul 2010

Studies suggest role for IL-10 in prevention and treatment of neurological disease in newborns

This bacterium, Escherichia coli K1, is the most common cause of meningitis in premature infants and the second most common cause of the disease in newborns. "The ineffectiveness of antibiotics in treating newborns with meningitis and the emergence of antibiotic-resistant strains of bacteria require new strategies," explains Nemani V. Prasadarao, PhD, associate professor of infectious disease at Childrens Hospital Los Angeles.

17 Jun 2010

ISB, GIND collaborate on whole-genome sequencing to identify drug targets for Huntington's Disease

The Institute for Systems Biology (ISB) of Seattle, WA, is collaborating with the Gladstone Institute of Neurological Disease (GIND) and its Taube-Koret Center for Huntington's Disease Research to use whole-genome sequencing to identify genes and novel drug targets related to the onset and progression of Huntington's disease (HD). The research team, led by GIND associate director and senior investigator Steven Finkbeiner, MD, PhD, will also use induced pluripotent stem (iPS) cells from patients with HD to screen for drugs that might delay, prevent, or even reverse this devastating condition.

16 Jun 2010

Neurological Disease News and Research

Parkinson’s disease linked to genetic alteration of immune system: Study

Scientists replace human gene to preserve photoreceptor function in retinal degeneration

Common genetic variation in HLA region associated with late-onset sporadic Parkinson's disease: Research

Spinal muscular atrophy may lead to cardiac dysfunction: Study

Alzheimer’s disease can now be predicted with 100% accuracy: Study

Scientists find new way to make beating heart cells from body's own cells

Detection of Alzheimer's before symptoms occur

FDA accepts for filing Cladribine Tablets NDA for MS

Major breakthrough in Alzheimer's disease research

BDSRA designates Nationwide Children's Hospital as Batten Disease Center of Excellence

Gladstone Institutes, H. Lundbeck collaborate to identify therapeutic candidates for neurological diseases

Improved delivery methods needed to advance gene therapy strategies for prostate cancer: Review

Larger heads may protect against Alzheimer’s disease: Study

MRC Technology, Genentech sign licensing agreement

Scientists identify new strategy for treating movement disorders

Brain fever mistaken as migraine kills a 30 year old woman

Depression and dementia may go hand in hand: Study

Researchers to study interventional endovascular therapy on symptoms and progression of MS

Studies suggest role for IL-10 in prevention and treatment of neurological disease in newborns

ISB, GIND collaborate on whole-genome sequencing to identify drug targets for Huntington's Disease

Neuroscience - Second Edition eBook

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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