Neurological Disease News and Research

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Novel imaging method used to map glycosylation patterns linked with Alzheimer’s disease

Using new methodology, University of Kentucky researchers have mapped the variations in sugar chains attached to brain proteins from deceased healthy individuals or individuals with Alzheimer's disease.

15 Dec 2021

Study could aid in the development of adaptive DBS treatments for obsessive-compulsive disorder

In a small study, researchers funded by the National Institutes of Health captured more than 1,000 hours of brain recordings from patients with OCD in the clinic and at home.

9 Dec 2021

Potentially neurotoxic SARS-CoV-2 protein fragments

Researchers investigate potentially amyloidogenic peptide fragments that could be associated with the neurological symptoms of COVID-19 and long-COVID.

30 Nov 2021

Study reveals the role of SPOP protein in an inherited form of ALS

The damaging effects of toxic proteins created in one inherited form of amyotrophic lateral sclerosis (ALS) are mediated by a protein called SPOP, according to a study published in the Proceedings of the National Academy of the Sciences.

8 Nov 2021

What are the risk factors for severe disease in children hospitalized for SARS-CoV-2 infection?

A new preprint describes an effort to describe the risk factors for severe COVID-19 in children.

2 Nov 2021

SARS-CoV-2 infection leads to greater risk of neurological complications than vaccines

Researchers from across the UK, led by the University of Oxford, have today reported on the risks of developing neurological complications following a positive COVID-19 PCR test, or a first dose of either the Oxford-AstraZeneca or Pfizer-BioNTech COVID-19 vaccinations.

27 Oct 2021

Using deep brain stimulation to treat Parkinson’s Disease

News-Medical spoke to Dr. Aryn Gittis about her latest research into Parkinson's disease and how deep brain stimulation could be used to help treat it.

27 Oct 2021

Tau reduction impacts brain cells involved in creating abnormal activity

With the school year well on its way, we all recognize the importance of getting students energized. However, we also know that overstimulated children can wreak havoc on a classroom, leaving a teacher trying to regain control of their group. The situation is very similar in the brain, where cells must remain active-;but in an orderly manner-;to carry out their many important tasks.

20 Oct 2021

Warming climate favors the transmission of West Nile Virus in Europe

Increases in temperatures as a result of climate change is favoring the transmission of the West Nile Virus (WNV) in parts of Europe, by creating more suitable conditions for the virus and its mosquito vectors to proliferate.

14 Oct 2021

Detailed atlas of the mammalian primary motor cortex will provide a springboard for future research

The NIH Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative Cell Census Network (BICCN) has unveiled an atlas of cell types and an anatomical neuronal wiring diagram for the mammalian primary motor cortex, derived from detailed studies of mice, monkeys, and humans.

6 Oct 2021

$35.1 million US grant focuses on investigating sleep disorder linked to neurodegeneration

People with rapid eye movement (REM) sleep behavior disorder act out their dreams. While sleeping safely in bed, for example, they might throw up their arms to catch an imaginary ball, or try to run from an illusory assailant.

5 Oct 2021

Legal consumption of alcohol and tobacco may increase the use of illicit drugs

The use of legal drugs (tobacco and alcohol) may lead to the use of cannabis, a new study led by the University of Bristol and published in the journal Addiction has found. The study also found evidence that cannabis use may lead to smoking initiation, and opioid dependence could lead to increased alcohol consumption.

30 Sep 2021

Methylation of TDP-43 DNA linked to age-dependent motor cortex involvement in ALS

Amyotrophic lateral sclerosis (ALS) is an intractable neurological disease. Aging is a risk factor for the accumulation of TDP-43 (transduction responsive region DNA-binding protein of 43kDa) in the motor cortex. TDP-43 is a protein that tends to accumulate in increasing amounts, and the amount is strictly controlled by the splicing of TDP-43. Through cell experiments and analysis of human brain tissue, researchers at Brain Research Institute, Niigata University, led by Akihiro Sugai, M.D., Ph.D., have found that methylation of TDP-43 DNA is involved in the background of motor cortex involvement with aging in ALS

29 Sep 2021

Infections impact blood vessel repair within the meninges following TBI or other cerebrovascular injuries

Viral Infection Slows Blood Vessel Repair After TBI: Seven days after mTBI, the blood vessels (stained in red) in the tissues around the brain are not completely repaired. A marker for intact vessels was used (labeled in green) to distinguish fully functional blood vessels (yellow) from ones that are still damaged (red).McGavern Lab, NINDS

24 Sep 2021

NIH awards funding to build a national study population of volunteers on long-term effects of COVID-19

The National Institutes of Health awarded nearly $470 million to build a national study population of diverse research volunteers and support large-scale studies on the long-term effects of COVID-19.

15 Sep 2021

Scientists identify a possible “Achilles’ heel” in the frustration of amyloid beta peptides

Progress on treating Alzheimer's disease has been frustratingly slow. A group of scientists in Houston suggest frustration at a very small scale may lead to a new path toward treatment.

14 Sep 2021

NIH researchers develop a detailed cellular map of chronic MS lesions

Chronic lesions with inflamed rims, or "smoldering" plaques, in the brains of people with multiple sclerosis (MS) have been linked to more aggressive and disabling forms of the disease.

10 Sep 2021

UC San Diego receives $12.25 million NIH grant to improve epilepsy treatment

The National Institutes of Health has awarded a $12.25 million grant to the University of California San Diego to develop and enhance brain-sensing and brain-stimulating platform technologies to enable treatment of drug-resistant epilepsy.

10 Sep 2021

Infections during adolescence linked to increased risk of developing MS later in life

According to a new study, severe infections during adolescence may lead to an increased risk of contracting MS later in life. "We're talking mainly about brain and spinal cord infections, but also respiratory tract infections," says Scott Montgomery, professor at örebro University.

8 Sep 2021

Don and Karen Cohn's $2.5 million gift supports UC San Diego Health neurosurgery program

Don and Karen Cohn have given $2.5 million to create the Don and Karen Cohn Chancellor's Endowed Chair in Neurosurgery at University of California San Diego School of Medicine.

4 Sep 2021