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Researchers shed new light on MS relapse during upper respiratory infections

For most of us, the flu is just the flu. We suffer through it for several days, and eventually bounce back. But for patients with multiple sclerosis (MS) and other neurological diseases, the flu can trigger a cascade of immune responses that result in a full-blown relapse of the disease.

8 Aug 2017

DNA-sensing mechanism of innate immune system controls cellular senescence

Cells in the body or in cultures eventually stop replicating. This phenomenon is called "senescence" and is triggered by shortening of telomeres, oxidative stress or genetic damage to the cells, either acute or simply due to the cell growing "old".

31 Jul 2017

Researchers provide evidence supporting need for gender-specific anti-inflammatory drugs

Perhaps you have come across the titles 'Men are from Mars, women are from Venus' or 'Why men don't listen and women can't read maps': just two of the many books and articles -- some enlightening or amusing and others irritating -- that theorise about fundamental differences between men and women.

26 Jul 2017

Immune system controls eye tissue regeneration in zebrafish, research finds

Researchers at Johns Hopkins Medicine report evidence that zebrafishes' natural ability to regenerate their eyes' retinal tissue can be accelerated by controlling the fishes' immune systems.

17 Jul 2017

MGH researchers identify novel mechanism behind resistance to angiogenesis inhibitors

A Massachusetts General Hospital research team has identified a novel mechanism behind resistance to angiogenesis inhibitors - drugs that fight cancer by suppressing the formation of new blood vessels.

14 Jul 2017

New study links hepatic inflammation to western diet

A new study in The American Journal of Pathology reports that mice fed a Western diet, which is high in fat and sugar, resulted in hepatic inflammation, especially in males. Moreover, liver inflammation was most pronounced in Western diet-fed male mice that also lacked farnesoid x receptor (FXR), a bile acid receptor.

12 Jul 2017

Ocular microbiome trains developing immune system to ward off pathogens, study shows

Bugs in your eyes may be a good thing. Resident microbes living on the eye are essential for immune responses that protect the eye from infection, new research shows.

11 Jul 2017

NYU researcher to study biological differences between men and women in oral cancer pain

Nicole Scheff, PhD, a postdoctoral fellow in the laboratory of Dr. Brian L. Schmidt, director of the NYU Bluestone Center for Clinical Research and the NYU Oral Cancer Center, both located at New York University College of Dentistry, has received a two-year, $120,000-plus F32 grant from the National Institute of Dental and Craniofacial Research.

10 Jul 2017

New portable device can quickly find markers of sepsis from single drop of blood

A new portable device can quickly find markers of deadly, unpredictable sepsis infection from a single drop of blood.

3 Jul 2017

Proteins impeding antitumor immunity could be 'Achilles heel' of some cancers

By comparing variations in protein expression in tumor samples from a single melanoma patient, researchers from the Johns Hopkins Bloomberg~Kimmel Institute and the Memorial Sloan-Kettering Cancer Center say their findings have the potential to reveal some of the mechanisms underlying response or resistance to immunotherapy drugs.

28 Jun 2017

Study finds link between upper GI infections and protein implicated in Parkinson’s disease

Acute and chronic infections in a person's upper gastrointestinal tract appear to be linked to Parkinson's disease, say scientists at Georgetown University Medical Center and their collaborators at the National Institutes of Health and other institutions.

28 Jun 2017

Wayne State awarded NIH grant to identify new therapeutic targets for bacterial keratitis

Wayne State University recently received a five-year, $1.925 million grant from the National Eye Institute of the National Institutes of Health to test the role of microRNAs (miRNAs) - a newly recognized level of gene expression regulation - in bacterial keratitis – an infection of the cornea caused by bacteria - as well as to identify new therapeutic targets and alternative treatment strategies.

15 Jun 2017

Hidden immune cells play key role in driving primary graft dysfunction

Northwestern Medicine scientists have discovered that a subset of immune cells called nonclassical monocytes (NCMs), previously unknown to reside in the lungs, play a key role in driving primary graft dysfunction (PGD), the leading cause of death after lung transplantation.

15 Jun 2017

New study suggests potential new therapeutic approach to septic shock recovery

A new study published online in the Journal of Leukocyte Biology suggests a new approach to treating patients with sepsis, one of the most frequent causes of morbidity and mortality in intensive care units.

1 Jun 2017

LMU researchers show how genetic variant in people of African ancestry modulates immune cells

A genetic variant that is particularly prevalent in people of African ancestry confers protection against malaria. LMU researchers have now shown how it modulates the properties of white blood cells that play a major role in immune defenses and inflammation.

1 Jun 2017

Pulmonary thrombosis-on-a-chip enables unprecedented study of blood responses to organ-level injury

The average human pair of lungs is permeated by a network of about 164 feet of blood vessels (roughly the width of a football field), including microscopic blood capillaries, which facilitate the diffusion of oxygen into the bloodstream in exchange for carbon dioxide.

23 May 2017

WSU scientists develop new approach to deliver therapeutics to tumors

For the first time, WSU researchers have demonstrated a way to deliver a drug to a tumor by attaching it to a blood cell. The innovation could let doctors target tumors with anticancer drugs that might otherwise damage healthy tissues.

16 May 2017

Researchers discover that microRNA can prevent excessive intestinal inflammation

An international team of researchers has discovered that a microRNA produced by certain white blood cells can prevent excessive inflammation in the intestine.

9 May 2017

Study: Use of white blood cell boosting drugs found to be safe during chemo-radiotherapy of lung cancer

A late breaking subanalysis of the phase III CONVERT trial presented at the European Lung Cancer Conference shows that white blood cell boosting drugs are safe during concurrent chemo-radiotherapy of small cell lung cancer (SCLC).

5 May 2017

Impaired effects of insulin can increase cancer risk, shows study

Over the decades, scientists have repeatedly shown that patients with increased levels of the hormone insulin in their blood can experience increased risks of cancer. Surprisingly, however, Joslin Diabetes Center researchers now have discovered that impaired effects of insulin also can boost these risks.

3 May 2017