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Researchers aim to test asthma drug for treating patients with heart disease

Researchers at Guy's and St Thomas' NHS Foundation Trust have launched an innovative new trial which aims to improve the recovery of patients with serious heart conditions.

27 Apr 2017

Air pollution may directly affect biology of upper airways to cause chronic sinus problems

Although human population studies have linked air pollution to chronic inflammation of nasal and sinus tissues, direct biological and molecular evidence for cause and effect has been scant.

18 Apr 2017

Study shows how early administration of old drug reduces damage during heart attack

Scientists at the Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC) have discovered a new mechanism of action of metoprolol, a drug that can reduce the damage produced during a heart attack if administered early.

18 Apr 2017

Research finds diagnostic tests to be less accurate for children with impaired kidney function

Breaking research published today in AACC's Journal of Applied Laboratory Medicine reveals that a number of diagnostic tests are less accurate when performed in pediatric patients with impaired kidney function.

17 Apr 2017

TSRI scientists develop easy method for synthesizing compounds with potential to treat lung disorders

Chemists at The Scripps Research Institute have developed a broad and strikingly easy method for synthesizing a class of molecules that have demonstrated value as pharmaceuticals.

17 Apr 2017

Research unravels how cytokines prevent multi-organ damage during parasitic infection

Cytokines are proteins secreted by several types of immune cells in response to infection, inflammation, or injury. Interleukin-17 (IL-17) is one such cytokine that causes inflammation, by controlling the production of other cytokines and mobilizing a type of white blood cell (neutrophil) that fights infections.

3 Apr 2017

Stem cell therapy can reduce lung inflammation in mouse model of COPD and cystic fibrosis

A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical stage, these findings have important potential implications for the future treatment of patients.

25 Mar 2017

Drug could activate innate anti-tumor immunity to eradicate aggressive prostate cancer in mice

Cabozantinib, a drug already used to treat patients with certain types of thyroid or kidney cancer, was able to eradicate invasive prostate cancers in mice by causing tumor cells to secrete factors that entice neutrophils - the first-responders of the immune system - to infiltrate the tumor, where they triggered an immune response that led to tumor clearance.

9 Mar 2017

Immune system defect makes Addison’s patients prone to respiratory infections

Research led by University of Birmingham scientists has found that people suffering from the adrenal disorder known as Addison's disease suffer from an immune system defect which makes them prone to potentially deadly respiratory infections.

1 Mar 2017

Clinical trial to test potential new drug treatment for osteoarthritis

The University of Liverpool, in partnership with AKL Research and Development Ltd, is to lead on a clinical trial to test a potential new drug treatment for osteoarthritis.

16 Feb 2017

Genetic variant encoded in NCF1 linked to increased risk for autoimmune diseases, study shows

Investigators at the Medical University of South Carolina report pre-clinical research showing that a genetic variant encoded in neutrophil cystolic factor 1 (NCF1) is associated with increased risk for autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis, and Sjögren's syndrome, in the January 2017 issue of Nature Genetics.

8 Feb 2017

Bacterial infection detector by Philips awarded prize for better use of antibiotics

Philips and Diagnostics Development win European Union ‘Horizon Prize – Better Use of Antibiotics’ for the rapid detection of bacterial infection on Philips’ Minicare I-20 platform.

8 Feb 2017

Immune system plays paradoxical role in breast cancer metastasis

The immune system plays a paradoxical role in the spread of breast cancer. Some immune cells contribute to metastasis, while other cells can be activated to strengthen the effect of chemotherapy.

7 Feb 2017

Thirdhand smoke exposure leads to biological effects on weight and cell development

The sticky residue left behind by tobacco smoke can do worse damage than stinking up furniture and discoloring walls.

3 Feb 2017

NIH researchers shed light on role of S. epidermidis toxin in bacterial sepsis

Staphylococcus epidermidis bacteria are a significant health concern for hospitalized infants, children and anyone with implanted medical devices.

2 Feb 2017

Virulence of bacterial infections dependent on presence of cytotoxins, study reports

Beginning in the mid-1980s, an epidemic of severe invasive infections caused by Streptococcus pyogenes (S. pyogenes), also known as group A streptococcus (GAS), occurred in the United States, Europe, and elsewhere.

2 Feb 2017

Scientists identify potential therapeutic solutions to combat age-related fibrosis

The wear and tear of life takes a cumulative toll on our bodies. Our organs gradually stiffen through fibrosis, which is a process that deposits tough collagen in our body tissue. Fibrosis happens little by little, each time we experience illness or injury. Eventually, this causes our health to decline.

30 Jan 2017

Researchers evaluate use of regenerative human umbilical cord for in-utero spina bifida repair

In a study to be presented Saturday, Jan. 28, in the oral concurrent session at 8:45 a.m. PST, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, researchers evaluated a possible regenerative patch by using human umbilical cord in two studies titled Cryopreserved Human Umbilical Cord (HUC) vs Acellular Dermal Matrix (ADM) for In-Utero Spina Bifida Repair and the study Conventional vs cryopreserved human umbilical cord (HUC) patch based on repair for in-utero spina bifida in a sheep model.

23 Jan 2017

Novel approach for imaging immune cell movements identifies initial steps in inflammatory arthritis

Using a novel approach for imaging the movement of immune cells in living animals, researchers from the Massachusetts General Hospital Center for Immunology and Inflammatory Diseases have identified what appear to be the initial steps leading to joint inflammation in a model of inflammatory arthritis.

20 Jan 2017

New research exposes cellular responses linked to bird flu vaccine

New research from Vanderbilt eavesdrops on gene expression in human immune system cells before and after vaccination against bird flu.

19 Jan 2017