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Researchers identify new immune cell that protects mice from lung infections during chemotherapy

St. Jude Children's Research Hospital investigators have identified a new form of an immune cell that protected mice from life-threatening lung infections under conditions that mimic cancer chemotherapy.

27 Sep 2016

Using the immune system to fight cancer: an interview with Dr Charles Akle

We all produce as many as 100,000 different types of cancer cells every day, which are recognized and eliminated by our extraordinarily efficient immune system. However, if something goes wrong with the immune system, and it no longer gets rid of these cells, then that’s when cancerous cells grow and become a problem.

12 Sep 2016

Researchers discover how immune cells transition from silent to merciless killing machines

Neutrophils are the superheroes of the body's immune system. Normally mild-mannered, they travel through the bloodstream until they reach an emergency situation, such as a cut or infection, where they switch into battle-mode to engulf and destroy foreign invaders.

9 Sep 2016

Researchers isolate cord blood factor that helps fight harmful inflammation

A factor found in umbilical cord blood could become the basis for developing a new therapy to fight harmful inflammation, University of Utah School of Medicine researchers report.

7 Sep 2016

Researchers reveal novel link between nicotine and inflammation

An Umeå-based team in collaboration with US researchers reveals a new link between nicotine and inflammation.

1 Sep 2016

LJI researchers reveal unanticipated way by which neutrophils defend against invading pathogens

As an arm of the innate immune system, white blood cells called neutrophils form the first line of defense against invading pathogens.

31 Aug 2016

Research findings pave way to effective strategies for treatment of visceral leishmaniasis

A study shows that stimulating the production of interleukin-17A (IL-17A), one of the cytokines released by cells of the immune system, can be an effective strategy for the treatment of visceral leishmaniasis, considered one of the six most important parasitic diseases affecting humans.

25 Aug 2016

Non-coding RNAs play key role in maintaining proper balance between fighting infection and inflammation

Special RNA molecules called long non-coding RNAs (lncRNAs) are key controllers for maintaining immune health when fighting infection or preventing inflammatory disorders, according to research led by Jorge Henao-Mejia, MD, PhD, an assistant professor of Pathology and Laboratory Medicine in the Perelman School of Medicine at the University of Pennsylvania.

25 Aug 2016

NYIT researcher aims to study link between wound healing problems and methamphetamine use

A chance observation in a Southern California fast food restaurant led Luis Martinez, Ph.D., to wonder about the connections behind wound healing problems and methamphetamine use.

19 Aug 2016

Researchers explain why secondary infection with MRSA kills influenza patients

Researchers have discovered that secondary infection with the Methicillin-resistant Staphylococcus aureus (MRSA) bacterium (or "superbug") often kills influenza patients because the flu virus alters the antibacterial response of white blood cells, causing them to damage the patients' lungs instead of destroying the bacterium.

16 Aug 2016

Naturally-occurring protein controls shape and activity of white blood cells to combat sepsis

Boosting levels of a protein that controls the shape and activity of a crucial group of white blood cells improves survival and recovery chances during sepsis.

8 Aug 2016

Wistar scientists discover marker for PMN-MDSCs in the blood of cancer patients

Myeloid-derived suppressor cells (MDSCs) are a population of immune cells that have been implicated in tumor resistance to various types of cancer treatment, including targeted therapies, chemotherapy and immunotherapy.

5 Aug 2016

Heart-resident macrophages promote neutrophil recruitment after ischemic injury

Tissue injury, such as occurs in response to a lack of oxygen, promotes an influx of immune cells to the site of damage.

5 Aug 2016

Amish farm environment protects children from asthma by shaping immune system

By probing the differences between two farming communities—the Amish of Indiana and the Hutterites of South Dakota—an interdisciplinary team of researchers found that specific aspects of the Amish environment are associated with changes to immune cells that appear to protect children from developing asthma.

4 Aug 2016

Malfunctioning of molecular signaling system suppresses mature blood cells battling against sepsis

When the body encounters an infection, a molecular signaling system ramps up the body's infection-fighting system to produce more white blood cells to attack invading bacteria.

30 Jul 2016

Specific urine proteins may be indicators of acute kidney injury in preterm infants

A new study indicates that several proteins are excreted differently in preterm infants with kidney injury compared with those with healthy kidneys.

29 Jul 2016

Scientists clarify mechanism of defective immune defense in G6PD patients

Favism is a common hereditary disease, affecting around 400 million people worldwide. It is caused by a lack of the enzyme glucose-6-phosphate dehydrogenase (G6PD).

26 Jul 2016

New study highlights role of TANs in regulating T cell responses in patients with early-stage lung cancer

The microenvironment of tumors is a mix of cell types, mostly comprised of inflammatory cells. White blood cells, recruited from the blood and bone marrow, represent a significant portion of these inflammatory cells and influence nearly all steps of tumor progression.

15 Jul 2016

Researchers discover strong genetic risk factor for IgA nephropathy

An international research collaboration has discovered a strong genetic risk factor for IgA nephropathy (IgAN) - the most common inflammatory kidney disease worldwide - and related renal dysfunction.

14 Jul 2016

CNIO study shows proinflammatory molecule IL-17A can be key factor in development of NASH and HCC

Non-alcoholic steatohepatitis (NASH) is a serious hepatic condition that precedes hepatocellular carcinoma (HCC) and is currently untreatable.

12 Jul 2016