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Pangolin study uncovers novel strains of coronaviruses and raises concerns about origin

Researchers identify novel HKU4-related coronavirus in a pangolin single-cell sequencing dataset.

22 Jun 2023

Uncovering the hidden genetic connections behind COVID-19 and comorbidities

Researchers performed a protein diffusion network analysis using tissue-specific GRNs to identify predispositions to COVID-19.

21 Jun 2023

The contribution of transcription factor ROB1 to the pathophysiology of C. albicans-induced candidal infections

Researchers evaluated the function of the zinc finger transcription factor ROB1 and its two phenotypically distinct alleles in the pathogenesis of Candida albicans infections.

20 Jun 2023

Urban jungle: How city living may impact mental health

Researchers explore the effects of the urban environment on adult mental health.

19 Jun 2023

New base-edited T-cells proven effective to treat lymphoblastic leukemia

Three young patients with relapsed T-cell leukemia have now been treated with base-edited T-cells, as part of a 'bench-to-bedside' collaboration between UCL and Great Ormond Street Hospital for Children (GOSH).

15 Jun 2023

Stronger defense: symptomatic malaria provides durable protection against reinfection

Researchers evaluated the immune protection conferred by symptomatic and asymptomatic P. falciparum.

14 Jun 2023

Heat-damaged DNA in food may contribute to genetic risks

Researchers have newly discovered a surprising and potentially significant reason why eating foods frequently cooked at high temperatures, such as red meat and deep-fried fare, elevates cancer risk. The alleged culprit: DNA within the food that's been damaged by the cooking process.

13 Jun 2023

The battle against avian influenza: genetic analysis unveils the origins of H5N1 outbreak

Researchers analyzed epidemiologic and phylogeographic characteristics of the avian influenza virus.

13 Jun 2023

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

A new research paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair."

13 Jun 2023

Researchers discover how a sugar molecule can affect cancer cell response to chemoradiotherapy

Researchers at Georgetown University's Lombardi Comprehensive Cancer Center and colleagues who have been exploring the complexities of biochemical pathways involved in cancer development have found that a form of glucose, a type of sugar, is intricately linked to a pathway used to build DNA molecules.

12 Jun 2023

SARS-CoV-2 hijacks body's metabolism to amplify COVID-19 severity

In a review article published in the journal Signal Transduction and Targeted Therapy, scientists have discussed host metabolic alteration triggered by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its effect on disease severity.

9 Jun 2023

Participation in physical activity should be promoted in those with high genetic risk of type two diabetes

Study aimed to understand whether there is a dose-response association between physical activity and incident type 2 diabetes.

7 Jun 2023

Vaginal microbial diversity and pregnancy outcomes

Researchers examined the diversity, community-type prevalence, and role of the vaginal microbiota in various pregnancy outcomes.

6 Jun 2023

New algorithm could improve the search for genetic cause of hereditary diseases

So far, it has not been possible to explain the causes of around half of all rare hereditary diseases. A Munich research team has developed an algorithm that predicts the effects of genetic mutations on RNA formation six times more precisely than previous models.

1 Jun 2023

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

In crisis, the nucleus calls antioxidant enzymes to the rescue. The nucleus being metabolically active is a profound paradigm shift with implications for cancer research.

1 Jun 2023

Study unlocks insights into how 'good fat' tissue could be harnessed to combat obesity, diabetes

New research has unlocked insights into how "good fat" tissue could potentially be harnessed to combat obesity and remove glucose from the blood, helping to control diabetes.

31 May 2023

New variants of human metapneumovirus surge in Spain post-COVID, highlighting evolution and impact

Investigating Human metapneumovirus (HMPV) prevalence, genetic diversity, and evolution in respiratory tract infections (RTIs) for better understanding and management.

31 May 2023

Important discovery could lead to new treatments for obesity and related diseases

Researchers at the University of East Anglia and the University of Cambridge have made an important discovery in the race to find treatments for obesity and related diseases, such as diabetes.

31 May 2023

Obesity strikes below the belt: Study reveals link between obesity and male infertility

The influence of obesity on male fertility is still under debate. In the present investigation, researchers scrutinized semen samples from both obese individuals and those of normal weight. The aim was to explore the relationship between obesity, the length of sperm telomeres, levels of mRNA associated with autophagy, and diverse semen characteristics.

29 May 2023

Genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene shaped by exogenous exposures

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, "Exogenous exposures shape genetic predisposition to lipids, Alzheimer's, and coronary heart disease in the MLXIPL gene locus."

25 May 2023

Nucleotide News and Research

Pangolin study uncovers novel strains of coronaviruses and raises concerns about origin

Uncovering the hidden genetic connections behind COVID-19 and comorbidities

The contribution of transcription factor ROB1 to the pathophysiology of C. albicans-induced candidal infections

Urban jungle: How city living may impact mental health

New base-edited T-cells proven effective to treat lymphoblastic leukemia

Stronger defense: symptomatic malaria provides durable protection against reinfection

Heat-damaged DNA in food may contribute to genetic risks

The battle against avian influenza: genetic analysis unveils the origins of H5N1 outbreak

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

Researchers discover how a sugar molecule can affect cancer cell response to chemoradiotherapy

SARS-CoV-2 hijacks body's metabolism to amplify COVID-19 severity

Participation in physical activity should be promoted in those with high genetic risk of type two diabetes

Vaginal microbial diversity and pregnancy outcomes

New algorithm could improve the search for genetic cause of hereditary diseases

Study sheds light on metabolic enzymes and processes essential for DNA damage repair

Study unlocks insights into how 'good fat' tissue could be harnessed to combat obesity, diabetes

New variants of human metapneumovirus surge in Spain post-COVID, highlighting evolution and impact

Important discovery could lead to new treatments for obesity and related diseases

Obesity strikes below the belt: Study reveals link between obesity and male infertility

Genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene shaped by exogenous exposures

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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