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Optimized genome-editing method opens the door to more effective treatment of genetic diseases

CRISPR-Cas9 is widely used to edit the genome by studying genes of interest and modifying disease-associated genes.

11 Apr 2023

The association between adiposity and cognitive function

Researchers assessed the associations between cognitive function and adiposity.

11 Apr 2023

Study finds higher BMI and smoking increased time to conception

Researchers evaluate the effect of lifestyle behaviors on various fertility and reproductive outcomes.

10 Apr 2023

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Pieren, D. K. J., Kuguel, S. G., Rosado, J., Robles, A. G., Rey-Cano, J., Mancebo, C., Esperalba, J., Falcó, V., Buzón, M. J., & Genescà, M. (2023). Limited induction of polyfunctional lung-resident memory T cells against SARS-CoV-2 by mRNA vaccination compared to infection. Nature Communications, 14(1). https://doi.org/10.1038/s41467-023-37559-w, https://www.nature.com/articles/s41467-023-37559-w

10 Apr 2023

Is mRNA decoding in humans structurally and kinetically distinct from bacteria?

Researchers examined molecular-level differences in ribosomal translational fidelity between humans and bacteria.

7 Apr 2023

Increasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage M1UK

Study explores the emerging invasive group A Streptococcus M1uk lineage,

7 Apr 2023

Study examines the causal role of insomnia symptoms on 11,409 health related-symptoms

Researchers performed Mendelian randomization phenome-wide association study of insomnia symptoms using 11,409 outcome variables.

6 Apr 2023

Research provides new insights into the underlying disease mechanisms for polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is the most common potentially lethal genetic disease-;about a half million people in the United States alone suffer from the condition.

4 Apr 2023

What is currently known about the mechanisms by which DNA tumor viruses evade uracil-mediated antiviral immunity?

Researchers reviewed the existing knowledge on the mechanisms through which DNA tumor viruses evade the antiviral immunity mediated through mis-incorporated uracil (U).

3 Apr 2023

Researchers report surprising first steps that promote resistance to commonly prescribed antibiotics

Antibiotic resistance is a global health threat. In 2019 alone, an estimated 1.3 million deaths were attributed to antibiotic resistant bacterial infections worldwide.

31 Mar 2023

Early life adversity linked to accelerated neurobiological aging, raising vulnerability to depression and Alzheimer's

scientists investigate the neurocognitive correlates of genetic vulnerability to major depressive disorder and Alzheimer's disease.

30 Mar 2023

Study shows how many HBeAg-negative patients can achieve permanent immune control of hepatitis B

More than half of patients who suffer from chronic hepatitis B have the e antigen (HBeAg)-negative form of the disease.

30 Mar 2023

Riboswitch may be the key to advance gene therapy, regenerative medicine

The Okinawa Institute of Science and Technology, in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression.

30 Mar 2023

Can poor diet and lifestyle behaviors modify genomic susceptibility to impulsivity?

Researchers evaluated the effects of poor diet quality and lifestyle behaviors on modifying the genomic susceptibility to impulsivity.

30 Mar 2023

Which functional and structural changes in the brain are associated with blood pressure elevation and cognitive impairment in humans?

Researchers identified brain structures related to cognitive impairment associated with elevated blood pressure (BP).

30 Mar 2023

Study finds minimal impact of SARS-CoV-2 genome variability on current diagnostic molecular systems

The authors of a new study under review at the journal Scientific Reports and currently posted to the Research Square preprint* server proposed a novel analysis pipeline to help identify mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reverse transcription-polymerase chain reaction (RT-PCR) primer regions.

29 Mar 2023

COVID-19 activates endogenous retroviruses within our genome

Researchers assess the impact of SARS-CoV-2 infection on endogenous retroviruses of the LTR69 subfamily.

28 Mar 2023

JPL study uses metagenomic sequencing to monitor microbial burden on spacecraft

A recent study published in PLOS ONE uses metagenomics to examine the microbial composition in samples obtained from the Jet Propulsion Laboratory.

28 Mar 2023

Possible pathways of C. auris emergence and the hypothetical role of interspecies transmission

Researchers summarized the current understanding of the emergence and ecologic niches of Candida auris.

27 Mar 2023

High-resolution mass spectrometric rapid identification of Candida auris

A recent study published in the Journal of Fungi used a novel OrbitrapTM high-resolution mass spectrometric technology coupled with liquid chromatography to identify geographically different clades of Candida auris (C. auris) isolates. This proof-of-concept methodology could accurately detect C. auris in the microbiology laboratory.

23 Mar 2023

Nucleotide News and Research

Optimized genome-editing method opens the door to more effective treatment of genetic diseases

The association between adiposity and cognitive function

Study finds higher BMI and smoking increased time to conception

COVID mRNA vaccines fall short in eliciting lung resident memory T cells compared to natural infection

Is mRNA decoding in humans structurally and kinetically distinct from bacteria?

Increasing reports of invasive Streptococcus pyogenes infections mandate surveillance for toxigenic lineage M1UK

Study examines the causal role of insomnia symptoms on 11,409 health related-symptoms

Research provides new insights into the underlying disease mechanisms for polycystic kidney disease

What is currently known about the mechanisms by which DNA tumor viruses evade uracil-mediated antiviral immunity?

Researchers report surprising first steps that promote resistance to commonly prescribed antibiotics

Early life adversity linked to accelerated neurobiological aging, raising vulnerability to depression and Alzheimer's

Study shows how many HBeAg-negative patients can achieve permanent immune control of hepatitis B

Riboswitch may be the key to advance gene therapy, regenerative medicine

Can poor diet and lifestyle behaviors modify genomic susceptibility to impulsivity?

Which functional and structural changes in the brain are associated with blood pressure elevation and cognitive impairment in humans?

Study finds minimal impact of SARS-CoV-2 genome variability on current diagnostic molecular systems

COVID-19 activates endogenous retroviruses within our genome

JPL study uses metagenomic sequencing to monitor microbial burden on spacecraft

Possible pathways of C. auris emergence and the hypothetical role of interspecies transmission

High-resolution mass spectrometric rapid identification of Candida auris

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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