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Gene therapy that reverses blindness in dogs could also help treat humans

A Michigan State University veterinary ophthalmologist has modified a gene therapy that reverses blindness in dogs that have a certain form of a disease known as progressive retinal atrophy, or PRA, and is now looking to advance the treatment for human use.

18 May 2018

Scientists find how immune system helps to clear HBV infection after treatment interruption

Scientists from Karolinska Institutet and Hannover Medical School have published two studies that provide insights into how the immune system responds and helps to clear a hepatitis B infection after treatment interruption.

17 May 2018

Study discovers genetic variations that increase heart attack risk for statin patients

A Vanderbilt-led research team has discovered genetic variations that increase the risk of heart attack even when patients are receiving a statin drug like Lipitor or Crestor to lower their blood cholesterol.

10 May 2018

New GP-write project to develop ultra-safe cells resistant to natural viruses

The Center for Excellence in Engineering Biology and the leadership of Genome Project-write today announced its first grand-scale community-wide project, to develop "ultra-safe cells" that resist natural viruses and potentially radiation, freezing, aging and cancer.

2 May 2018

Specific type of RNA editing plays key role in protein variation in cancer cells, shows research

A multi-center study led by The University of Texas MD Anderson Cancer Center has shed light on why proteins, the seedlings that serve as the incubator for many cancers, can vary from cancer to cancer and even patient to patient, a discovery that adds to a growing base of knowledge important for developing more effective precision therapies.

27 Apr 2018

New technique harnesses 'natural barcodes' to facilitate better cell tracking

Each of us carries in our genomes about 10 million genetic variations called single nucleotide polymorphisms, which represent a difference of just one letter in the genetic code.

24 Apr 2018

NuProbe to commercialize Wyss Institute's new technology to facilitate precision medicine

NuProbe Global will commercialize the Wyss Institute's DNA nanotechnology-based variant-detecting method as a fast, low-cost and multiplexed molecular diagnostic for different disease areas, including cancer and infectious diseases.

24 Apr 2018

Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects

Revealing surprising answers to a long-standing enigma about the brain target of the anti-obesity hormone leptin, neuroscientists at Tufts University School of Medicine have used CRISPR genome editing to identify a neural circuit in the hypothalamus as the primary mechanism in mediating leptin's anti-obesity and anti-diabetes effects and have identified two distinct mechanisms underlying leptin's inhibition of appetite.

19 Apr 2018

New long-acting delivery system has potential to lessen side effects from NRTIs

An HIV diagnosis, while no longer constituting a death sentence, brings with it a lifetime, daily regimen of medication to help continually combat the virus.

27 Mar 2018

Scientists use CRISPR to develop a genome surveillance tool

Scientists have converted CRISPR/Cas9 into a genome surveillance tool, in an effort to develop a more effective way of fighting disease.

27 Mar 2018

Study identifies genetic factors linked to severity of acute viral bronchiolitis

A scientific study conducted at the State University of Campinas (UNICAMP) in São Paulo State, Brazil, has identified genetic factors associated with the severity of acute viral bronchiolitis. The study was supported by the Sao Paulo Research Foundation - FAPESP. Its results were published in the journal Gene.

27 Mar 2018

Researchers develop comprehensive map of genetic risk factors for stroke

Stroke is a serious disease affecting blood flow to and from the brain, and is the second leading cause of death worldwide. Stroke is characterized by a sudden onset of neurological dysfunction, caused by a blood clot or hemorrhage in a cerebral artery. While many genetic variants and lifestyle behaviors have been identified as risk factors for stroke, the genetic basis for the disease is unknown.

26 Mar 2018

Genetic variant discovery could improve safety, effectiveness of drugs for asthma and COPD

Research from the University of Liverpool, published today in Lancet Respiratory Medicine, identifies a genetic variant that could improve the safety and effectiveness of corticosteroids, drugs that are used to treat a range of common and rare conditions including asthma, and chronic obstructive pulmonary disease (COPD).

16 Mar 2018

New technique provides pairs of genetically matched cells to study disease

Researchers led by Dr. Knut Woltjen report a new gene editing method that can modify a single DNA base in the human genome with absolute precision.

6 Mar 2018

AD polygenic risk score could identify younger population with mild cognitive impairment

For the first time, an international team of scientists, led by researchers at University of California San Diego School of Medicine, have determined that an Alzheimer's disease (AD) polygenic risk score can be used to correctly identify adults with mild cognitive impairment (MCI) who were only in their 50s. MCI is considered a precursor to AD.

5 Mar 2018

Scientists identify single genetic change in Salmonella that plays key role in bloodstream infections

Scientists have identified a single genetic change in Salmonella that is playing a key role in the devastating epidemic of bloodstream infections currently killing around 400,000 people each year in sub-Saharan Africa.

1 Mar 2018

ASU researchers uncover crucial step in telomerase enzyme catalytic cycle

Can we stay young forever, or even recapture lost youth? Research from the laboratory of Professor Julian Chen in the School of Molecular Sciences at Arizona State University recently uncovered a crucial step in the telomerase enzyme catalytic cycle.

27 Feb 2018

Researchers develop new tool that provides 3D view of metabolic processes

An international team of researchers has developed a computational resource that provides a 3D view of genes, proteins and metabolites involved in human metabolism.

27 Feb 2018

Combined analysis makes risk prediction for colorectal cancer more precise

If first-degree relatives are affected by colorectal cancer, this indicates a person's own elevated risk of developing bowel cancer. The same holds true for people who have large numbers of genetic risk markers in their genome.

26 Feb 2018

Scientists reveal new insights into mechanism of gene regulation by 'magic spot'

Using an innovative crystallization technique for studying three-dimensional structures of gene transcription machinery, an international team of researchers, led by scientists at Penn State, has revealed new insights into the long debated action of the "magic spot"--a molecule that controls gene expression in Eschericahia coli and many other bacteria when the bacteria are stressed.

24 Feb 2018

Nucleotide News and Research

Gene therapy that reverses blindness in dogs could also help treat humans

Scientists find how immune system helps to clear HBV infection after treatment interruption

Study discovers genetic variations that increase heart attack risk for statin patients

New GP-write project to develop ultra-safe cells resistant to natural viruses

Specific type of RNA editing plays key role in protein variation in cancer cells, shows research

New technique harnesses 'natural barcodes' to facilitate better cell tracking

NuProbe to commercialize Wyss Institute's new technology to facilitate precision medicine

Genome editing identifies neural circuit behind leptin’s anti-obesity and anti-diabetes effects

New long-acting delivery system has potential to lessen side effects from NRTIs

Scientists use CRISPR to develop a genome surveillance tool

Study identifies genetic factors linked to severity of acute viral bronchiolitis

Researchers develop comprehensive map of genetic risk factors for stroke

Genetic variant discovery could improve safety, effectiveness of drugs for asthma and COPD

New technique provides pairs of genetically matched cells to study disease

AD polygenic risk score could identify younger population with mild cognitive impairment

Scientists identify single genetic change in Salmonella that plays key role in bloodstream infections

ASU researchers uncover crucial step in telomerase enzyme catalytic cycle

Researchers develop new tool that provides 3D view of metabolic processes

Combined analysis makes risk prediction for colorectal cancer more precise

Scientists reveal new insights into mechanism of gene regulation by 'magic spot'

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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