Nucleotides News and Research

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Research finds higher rate of rare tandem repeats in the genomes of individuals with schizophrenia

In our cells, the language of DNA is written, making each of us unique. A tandem repeat occurs in DNA when a pattern of one or more nucleotides – the basic structural unit of DNA coded in the base of chemicals cytosine (C), adenine (A), guanine (G) and thymine (T) – is repeated multiple times in tandem. An example might be: CAG CAG CAG, in which the pattern CAG is repeated three times.

30 Nov 2022

Study shows clear shifts in SARS-CoV-2 mutational spectrum during evolution

Researchers examined whether the mutational process of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) itself has changed during the evolution of SARS-CoV-2.

23 Nov 2022

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Johns Hopkins Medicine researchers have revamped an anti-cancer drug to better target cancer cells and leave healthy tissues unharmed. Scientists have dubbed this type of targeted approach a "prodrug" -; a medicine designed to release its payload in a particular area of the body and in no other areas.

17 Nov 2022

Researchers develop a new method to map the spatial evolution of cancers

Researchers developed a genetic clone mapping workflow centered around base-specific in situ sequencing (BaSISS) technology to derive quantitative maps of multiple genetic clones of cancer cells.

11 Nov 2022

MicroRNAs can upregulate proteins in addition to downregulating protein production

microRNAs can play a role in cancer development and are thought to exclusively suppress protein expression in dividing cells, such as tumor cells.

10 Nov 2022

High-quality reference genome assembly of the Nile rat facilitates diabetes research

Model organisms are essential for biomedical research and have enabled many important scientific discoveries. The ability to sequence the genomes of these models is a powerful tool to study the genetic factors that impact human health.

9 Nov 2022

Study shows likely SARS-CoV-2 transmission between different rooms of a quarantine hotel

The results of this study, published in the Emerging Infectious Diseases journal, underline the enhanced transmissibility of the Omicron variants of the virus, which takes advantage of small airstreams to jump to new hosts. "Our findings emphasize the importance of ventilation and integrity of building structure in quarantine facilities."

6 Nov 2022

Study reports on a novel property of antibodies, light chain coherence

Researchers investigate whether pairs of unrelated B-cells that have similar heavy chains also have the same light chains.

30 Oct 2022

The epigenetic alterations of monocytes in severe COVID-19

Researchers performed DNA methylation analysis on monocytes in the peripheral blood samples obtained from severe COVID-19 patients.

28 Oct 2022

Advanced type of nanoparticle could help fight hard-to-treat cancers

Nanoparticles, or tiny molecules that can deliver a payload of drug treatments and other agents, show great promise for treating cancers.

27 Oct 2022

COVID-19 and the gut

Researchers summarize current knowledge about underlying mechanisms and potential therapeutic approaches for the effects of COVID-19 on the gut.

26 Oct 2022

Novel method deploys nanopore tweezers to facilitate inhibition of SARS-CoV-2 helicase at single-nucleotide resolution

In a new study, researchers visualized the mechanism of action and inhibition of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 13 (NSP13) at high spatio-temporal resolution.

13 Oct 2022

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

In a new study, researchers pursued direct-acting severe acute respiratory syndrome coronavirus-2 drugs that compete for nucleotide-binding pockets (NBPs) of SARS-CoV-2 proteins.

11 Oct 2022

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

A new paper reviews current knowledge of RdRp inhibitors that could be developed further to provide broadly effective antivirals against SARS-CoV-2 in particular and CoVs in general.

10 Oct 2022

ASU scientists discover an unusual RNA biogenesis pathway

For the very first time, a study led by Julian Chen and his group in Arizona State University's School of Molecular Sciences and the Biodesign Institute's Center for the Mechanism of Evolution, has discovered an unprecedented pathway producing telomerase RNA from a protein-coding messenger RNA (mRNA).

3 Oct 2022

Nucleotides News and Research

Research finds higher rate of rare tandem repeats in the genomes of individuals with schizophrenia

Study shows clear shifts in SARS-CoV-2 mutational spectrum during evolution

Augmented drug preferentially eliminates cancer cells but does not harm healthy cells

Researchers develop a new method to map the spatial evolution of cancers

MicroRNAs can upregulate proteins in addition to downregulating protein production

High-quality reference genome assembly of the Nile rat facilitates diabetes research

Study shows likely SARS-CoV-2 transmission between different rooms of a quarantine hotel

Study reports on a novel property of antibodies, light chain coherence

The epigenetic alterations of monocytes in severe COVID-19

Advanced type of nanoparticle could help fight hard-to-treat cancers

COVID-19 and the gut

Novel method deploys nanopore tweezers to facilitate inhibition of SARS-CoV-2 helicase at single-nucleotide resolution

Researchers explore drug-repurposing candidates acting against nucleotide-binding pockets of multiple SARS-CoV-2 proteins

RNA-dependent RNA polymerase inhibitors in COVID-19 therapy

ASU scientists discover an unusual RNA biogenesis pathway

Study investigates long-range RNA-RNA interactions of SARS-CoV-2

Study shows vaccine-derived poliovirus in infant with severe immunodeficiency

Self-replicating intradermal RNA vaccine against SARS-CoV-2

Intranasally delivered neutralizing antibody protects against SARS-CoV-2 Omicron and Delta variants

dsDNA Quantification for NGS Quality Control

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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