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HLA-Cw*0602 gene variation detected as a high risk for psoriasis

A specific genetic region that has been increasingly identified as the strongest genetic link to psoriasis has an even more significant role in the chronic skin disease than has been suspected, University of Utah medical researchers show in a new study.

27 Aug 2009

Standard Reference Material for determining essential nutrient concentration in infant and adult nutritional formula

Chemists at the National Institute of Standards and Technology (NIST) have issued a new certified reference material-a standardized sample backed by NIST-for determining the concentrations of vitamins, minerals and other nutrients in infant and adult nutritional formula and similar products.

27 Aug 2009

Relationship between the CD14 variation and the formation of portal lymphoid aggregates discovered

It is still unknown why the natural history of chronic disease caused by hepatitis C virus (HCV), which currently infects 3% of the world's population, varies from mild in some patients to rapidly progressing in others. Age, sex, alcohol consumption and liver sensitivity to gut-derived bacterial endotoxins, were the early factors defined to enhance the risk of fibrosis progression.

27 Aug 2009

University of Maryland researchers perform a genome-wide association study of ADP-stimulated platelet aggregation

Patients with a certain genetic variation who received the antiplatelet drug clopidogrel had a decreased platelet response to treatment and among those who had percutaneous coronary intervention (procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries) had an increased risk of having a cardiovascular event in the following year than patients who did not have this variant, according to a study in the August 26 issue of JAMA.

25 Aug 2009

New technique developed to identify gene copy number variations

A research team led by Associate Professor Jonathan Sebat, Ph.D., of Cold Spring Harbor Laboratory (CSHL) has developed a sensitive and accurate way of identifying gene copy number variations (CNVs).

25 Aug 2009

Santaris Pharma to discover and develop new RNA-based medicines for treating rare genetic disorders

Santaris Pharma A/S, a privately-held biopharmaceutical company focused on developing RNA-based drugs targeted to disease-related mRNAs and microRNAs, today announced a multi-year worldwide strategic alliance with Shire plc to discover and develop new RNA-based medicines to treat rare genetic disorders.

24 Aug 2009

Discovery of inherited gene variants that account for 37 percent of childhood acute lymphoblastic leukemia

Scientists at St. Jude Children’s Research Hospital have identified inherited variations in two genes that account for 37 percent of childhood acute lymphoblastic leukemia (ALL), including a gene that may help predict drug response.

16 Aug 2009

New study suggests possible genetic link between environmental toxins and myeloma

The International Myeloma Foundation (IMF) today said newly published data may provide a possible genetic link between environmental toxins and bone disease in multiple myeloma. Myeloma, also called multiple myeloma, is a cancer of cells in the bone marrow that affect production of blood cells and can damage bone.

14 Aug 2009

Discovery of possible genetic link between environmental toxins and bone disease in multiple myeloma

The International Myeloma Foundation (IMF) - supporting research and providing education, advocacy and support for myeloma patients, families, researchers and physicians - today said newly published data may provide a possible genetic link between environmental toxins and bone disease in multiple myeloma.

13 Aug 2009

Inhibitex reports Q2 2009 financials

Inhibitex, Inc. (Nasdaq: INHX), today announced its financial results for the second quarter ended June 30, 2009. The Company held cash, cash equivalents and short-term investments of $24.5 million at June 30, 2009, as compared to $33.1 million at December 31, 2008.

12 Aug 2009

HIV genome decoded

"Researchers at the University of North Carolina at Chapel Hill have decoded the entire HIV genome, opening the door to understanding how viruses infect humans – knowledge that could lead to new antiviral drugs," the Triangle Business Journal reports. The building block of HIV is a single stranded RNA, not a double stranded DNA (Gallagher, 8/6).

6 Aug 2009

Structure of an entire HIV genome decoded

The structure of an entire HIV genome has been decoded for the first time by researchers at the University of North Carolina at Chapel Hill. The results have widespread implications for understanding the strategies that viruses, like the one that causes AIDS, use to infect humans.

5 Aug 2009

Genetic link to ovarian cancer found

Scientists have located a region of DNA which - when altered - can increase the risk of ovarian cancer according to research published in Nature Genetics today.

3 Aug 2009

Discovery of gene linked to follicular lymphoma

California and Arizona researchers have identified a gene variant that carries nearly twice the risk of developing an increasingly common type of blood cancer, according to a study published online today by the science journal Nature Genetics.

20 Jul 2009

Discovery of five genetic variants related to blood pressure in African-Americans

A team led by researchers from the National Institutes of Health (NIH) has reported the discovery of five genetic variants related to blood pressure in African-Americans, findings that may provide new clues to treating and preventing hypertension. The effort marks the first time that a relatively new research approach, called a genome-wide association study, has focused on blood pressure and hypertension in an African-American population.

17 Jul 2009

Scientists discover 27 genes associated with Asperger's syndrome, autistic traits and empathy

Scientists from the University of Cambridge have identified 27 genes that are associated with either Asperger Syndrome (AS) and/or autistic traits and/or empathy. The research will be published tomorrow in the journal Autism Research. This is the first candidate gene study of its kind.

15 Jul 2009

New research tool – map of genomic variation for diagnosing and identifying genetic problems

Genetics researchers have unveiled a powerful new resource for scientists and health providers studying human illnesses -- a reference standard of deletions and duplications of DNA found in the human genome. Drawn from over 2,000 healthy persons, the study provides one of the deepest and broadest sets of copy number variations (CNVs) available to date, along with a new research tool for diagnosing and identifying genetic problems in patients.

15 Jul 2009

DNA alterations on human chromosome 9 linked to glioblastoma

Mayo Clinic researchers and colleagues at the University of California San Francisco (UCSF) have found a connection between DNA alterations on human chromosome 9 and aggressive brain cancer known as glioblastoma. The findings are reported in the current online issue of Nature Genetics.

5 Jul 2009

Backtracking and proofreading in DNA transcription

Accuracy is essential for life, so in converting the information stored in DNA into a form in which it can be used, a high level of precision is required. Dr Tanniemola Liverpool from the University of Bristol Department of Mathematics, working with colleagues from the University of Leeds, has developed a mathematical model for how the required accuracy is achieved.

23 Jun 2009

DNA template could explain evolutionary shifts

Rearrangements of all sizes in genomes, genes and exons can result from a glitch in DNA copying that occurs when the process stalls at a critical point and then shifts to a different genetic template, duplicating and even triplicating genes or just shuffling or deleting part of the code within them, said researchers from Baylor College of Medicine in a recent report in the journal Nature Genetics.

22 Jun 2009

Nucleotides News and Research

HLA-Cw*0602 gene variation detected as a high risk for psoriasis

Standard Reference Material for determining essential nutrient concentration in infant and adult nutritional formula

Relationship between the CD14 variation and the formation of portal lymphoid aggregates discovered

University of Maryland researchers perform a genome-wide association study of ADP-stimulated platelet aggregation

New technique developed to identify gene copy number variations

Santaris Pharma to discover and develop new RNA-based medicines for treating rare genetic disorders

Discovery of inherited gene variants that account for 37 percent of childhood acute lymphoblastic leukemia

New study suggests possible genetic link between environmental toxins and myeloma

Discovery of possible genetic link between environmental toxins and bone disease in multiple myeloma

Inhibitex reports Q2 2009 financials

HIV genome decoded

Structure of an entire HIV genome decoded

Genetic link to ovarian cancer found

Discovery of gene linked to follicular lymphoma

Discovery of five genetic variants related to blood pressure in African-Americans

Scientists discover 27 genes associated with Asperger's syndrome, autistic traits and empathy

New research tool – map of genomic variation for diagnosing and identifying genetic problems

DNA alterations on human chromosome 9 linked to glioblastoma

Backtracking and proofreading in DNA transcription

DNA template could explain evolutionary shifts

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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