Oncogene News and Research

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An oncogene is a gene that, when mutated or expressed at high levels, helps turn a normal cell into a tumor cell.

Addressing research gaps: The UK's efforts to study lung cancer in never smokers

Study aimed to understand the specific needs of lung cancer in never smokers (LCINS) patients.

25 Jul 2023

Research reveals therapeutic potential of novel compound in inhibiting oncogene translation

Cutting-edge research at the Luxembourg Institute of Health reveals the ground-breaking therapeutic potential of the compound FL3 in inhibiting oncogene translation and rewiring cancer cell metabolism, opening up new therapeutic opportunities for leukemia patients.

24 Jul 2023

Aneuploidy could function as a therapeutic target for cancer

Cancer cells with extra chromosomes depend on those chromosomes for tumor growth, a new Yale study reveals, and eliminating them prevents the cells from forming tumors.

6 Jul 2023

Senescent cells unlock the secret to luscious hair growth

The study findings indicate a peculiar pathway of regulation of hair growth by hair stem cells that is mediated by dermal melanocytes in senescence.

25 Jun 2023

Using Src N-terminal regulatory element as potential oncotarget

A new research perspective was published in Oncotarget's Volume 14 on May 19, 2023, entitled, "Targeting the Src N-terminal regulatory element in cancer."

9 Jun 2023

Scientists unveil a metabolic Achilles' heel in pancreatic cancer

Research unveils the significance of uridine as a metabolic fuel in pancreatic ductal adenocarcinoma (PDA) cells under glucose-deprived conditions. Uridine utilization, mediated by uridine phosphorylase 1 (UPP1), supports redox balance, survival, and proliferation in PDA, highlighting its potential as a novel therapeutic target in the treatment of this resistant cancer.

23 May 2023

The role of RNA splicing in one of the deadliest forms of pancreatic cancer

In this interview, we spoke to Adrian Krainer, a Professor at Cold Spring Harbor Laboratory, about his latest research into the role of RNA splicing in one of the deadliest forms of pancreatic cancer.

22 May 2023

Study finds socio-economic inequalities in access to novel therapies for many NSCLC patients

Novel anti-cancer therapies were not accessible to more than half of the patients in England who were diagnosed with non-small cell lung cancer, according to a new study published in the Journal of Thoracic Oncology, the official journal of the International Association for the Study of Lung Cancer.

19 May 2023

Identify the underlying mechanism associated with the initiation of focal amplification in breast cancer

Identifying the underlying mechanism associated with the initiation of focal amplification in breast cancer.

19 May 2023

Mast cells play a crucial role in the development of chronic myeloid leukemia

Chronic myeloid leukemia (CML) is a type of blood cancer that arises from malignant changes in blood-forming cells of the bone marrow.

16 May 2023

Researchers discover key epigenetic alteration associated with clinical course of liver cancer

Researchers at the Josep Carreras Leukaemia Research Institute, led by Dr. Manel Esteller, have discovered a key epigenetic alteration that anticipates the clinical course of liver cancer.

16 May 2023

Biomarker signature test can predict tumor response to bladder cancer immunotherapy

In a discovery that could improve the survival of bladder cancer patients, Northwestern Medicine scientists have developed a biomarker signature test to predict which tumors will respond to immunotherapy.

27 Apr 2023

Researchers investigate the roles of STAT3α and STAT3β isoforms in aggressive breast cancer

A new research paper was published in Oncotarget's Volume 14 on April 24, 2023, entitled, "Differential silencing of STAT3 isoforms leads to changes in STAT3 activation."

26 Apr 2023

TONSL gene could be a new target for breast cancer treatment

While trying to understand what initiates breast cells to become cancerous, researchers at the Vera Bradley Foundation Center for Breast Cancer Research at Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a new target for breast cancer treatment.

20 Apr 2023

New $2.3 million NCI grant awarded to Georgia Cancer Center to improve survival of patients with AML

Acute myeloid leukemia (AML) is a cancer that affects blood cells in the bone marrow -; the spongy tissue inside certain bones, where new blood cells are made.

17 Apr 2023

Researchers show how the EBV virus exploits genomic weaknesses to cause cancer

The Epstein-Barr virus (EBV) is easily spread through bodily fluids, primarily saliva, such as kissing, shared drinks or using the same eating utensils.

13 Apr 2023

Clinical trial may change the paradigm of care for patients with ALK-driven high-risk neuroblastoma

In a significant step for the treatment of neuroblastoma, an international group of researchers led by Children's Hospital of Philadelphia (CHOP), Winship Cancer Institute of Emory University and the New Approaches to Neuroblastoma Therapy (NANT) Consortium has shown that the targeted therapy lorlatinib is safe and effective in treating high-risk neuroblastoma.

4 Apr 2023

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