Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Cellular models based on reprogrammed human cells could boost development of efficient therapies

Studies on diseases that affect the human brain are usually based on animal models which cannot reproduce the complexity of human neuropathies.

22 Dec 2022

Using 3D patient tumor avatars to guide cancer treatment decisions

At any time, most cancer patients are receiving a treatment that does not significantly benefit them while enduring bodily and financial toxicity.

20 Dec 2022

UQ-led project uses 'brain in a dish' to study effects of the Zika virus

A University of Queensland-led project has used a 'brain in a dish' to study the effects of the Zika virus, taking research a step closer towards developing drugs to combat the infection.

12 Dec 2022

Bioengineered soluble ACE2 for brain protection against SARS-CoV-2 infection

Researchers compared the efficiency of bioengineered soluble ACE-2 concerning brain protection during COVID-19.

12 Dec 2022

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

Researchers assessed the association between farnesoid X receptor (FXR) inhibition and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

9 Dec 2022

New approach enables robust intestinal mini-organs to be grown more easily in the lab

Growing human body parts in the lab is a common trope of horror movies and sci-fi books. But growing miniature organ-like tissues in the lab is already within our reach.

6 Dec 2022

Innovative precision oncology enabled by micro-organospheres derived from patients

The development of an automatic microfluidics droplet platform to rapidly generate patient-derived models of cancer.

6 Dec 2022

Multiomics analysis of kidney metabolism reveals a gatekeeper for viral infections

Our kidney filters 180 liters of blood every day and retains nutrients through a process called 'endocytosis' and through active transport in the kidney cells.

2 Dec 2022

Chemical residue from commercial dishwashers causes gut epithelial barrier damage

Residue from rinse agents is left behind on dishes after they are cleaned in professional-grade dishwashers.

1 Dec 2022

Researchers develop 3D organoid model to advance understanding of gastroesophageal junction cancer

Researchers at Johns Hopkins Medicine say they have created a laboratory-grown three-dimensional "organoid" model that is derived from human tissue and designed to advance understanding about how early stages of cancer develop at the gastroesophageal junction (GEJ) — the point where the digestive system's food tube meets the stomach.

1 Dec 2022

Scientists discover new potential mechanism for vision loss

Visual cells in the human retina may not simply die in some diseases, but are mechanically transported out of the retina beforehand.

1 Dec 2022

UCSC engineers develop new method to automate the growth of cerebral organoids

A team of engineers at UC Santa Cruz has developed a new method for remote automation of the growth of cerebral organoids – miniature, three-dimensional models of brain tissue grown from stem cells.

28 Nov 2022

The potential of Sofosbuvir against COVID-19 neurological symptoms

Researchers discuss how SARS-CoV-2 infects cortical neurons and damages their synapses that form the connection between brain cells.

25 Nov 2022

Scientists provide metrics for organ development

Organs in the human body have complex networks of fluid-filled tubes and loops. They come in different shapes and their three-dimensional structures are differently connected to each other, depending on the organ.

21 Nov 2022

Using induced pluripotent stem cells to recreate the adrenal gland in a petri dish

Sitting atop the kidneys, the adrenal gland plays a pivotal role in maintaining a healthy body. Responding to signals from the brain, the gland secretes hormones that support critical functions like blood pressure, metabolism, and fertility.

21 Nov 2022

Brain organoids reveal how alcohol exposure impairs the development and functioning of new brain cells

Alcohol consumption during pregnancy poses significant peril to the healthy development of the unborn child. There is no known safe amount of alcohol during pregnancy.

20 Nov 2022

Researchers make first bone marrow 'organoids' to capture key features of human bone marrow

Scientists from Oxford University and the University of Birmingham have made the first bone marrow 'organoids' that capture the key features of human bone marrow.

15 Nov 2022

Researchers discover residual tumor cells responsible for colon cancer relapse

Colon cancer is the third most common cancer in the world, with about 2 million new cases each year. Most patients are diagnosed when the tumor is still located in the colon or rectum.

9 Nov 2022

Researchers use brain organoids to show how SARS-CoV-2 virus infects cortical neurons

Using human brain organoids, an international team of researchers, led by scientists at University of California San Diego School of Medicine and Sanford Consortium, has shown how the SARS-CoV-2 virus that causes COVID-19 infects cortical neurons and specifically destroys their synapses -; the connections between brain cells that allow them to communicate with each other.

3 Nov 2022

First preclinical model to study the pathobiology of appendiceal cancer

Appendiceal cancer (malignancies of the appendix, a small tissue pouch that is part of the gastrointestinal tract) is very rare, occurring in perhaps one or two people per 1 million per year.

1 Nov 2022

Organoids News and Research

Further Reading

Cellular models based on reprogrammed human cells could boost development of efficient therapies

Using 3D patient tumor avatars to guide cancer treatment decisions

UQ-led project uses 'brain in a dish' to study effects of the Zika virus

Bioengineered soluble ACE2 for brain protection against SARS-CoV-2 infection

What is the association between farnesoid X receptor inhibition and protection against COVID-19?

New approach enables robust intestinal mini-organs to be grown more easily in the lab

Innovative precision oncology enabled by micro-organospheres derived from patients

Multiomics analysis of kidney metabolism reveals a gatekeeper for viral infections

Chemical residue from commercial dishwashers causes gut epithelial barrier damage

Researchers develop 3D organoid model to advance understanding of gastroesophageal junction cancer

Scientists discover new potential mechanism for vision loss

UCSC engineers develop new method to automate the growth of cerebral organoids

The potential of Sofosbuvir against COVID-19 neurological symptoms

Scientists provide metrics for organ development

Using induced pluripotent stem cells to recreate the adrenal gland in a petri dish

Brain organoids reveal how alcohol exposure impairs the development and functioning of new brain cells

Researchers make first bone marrow 'organoids' to capture key features of human bone marrow

Researchers discover residual tumor cells responsible for colon cancer relapse

Researchers use brain organoids to show how SARS-CoV-2 virus infects cortical neurons

First preclinical model to study the pathobiology of appendiceal cancer

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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