Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

Study uses 3D cervical organoids to show the danger of multiple infections

Infections with several pathogens simultaneously increase the risk of cervical cancer—these results from a study conducted on artificial 3D tissue models.

25 Feb 2022

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

In a recent study posted to the Research Square* preprint server, which is under consideration at Scientific Reports, a team of researchers developed a novel human Alveolar Epithelial Lentivirus immortalized (hAELVi) cell infection model to estimate the replication potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses in the lower respiratory tract of humans.

23 Feb 2022

Exposure to endocrine disrupting mixtures during pregnancy impacts children's brain development

By linking human population studies with experiments in cell and animal models, researchers have provided evidence that complex mixtures of endocrine disrupting chemicals impact children's brain development and language acquisition.

17 Feb 2022

Human nose organoids provide better understanding of the first steps toward SARS-CoV-2 infection

Preclinical models that recapitulate aspects of human airway disease are essential for the advancement of novel therapeutics and vaccines.

16 Feb 2022

New DisCo method allows scRNA-seq to efficiently process samples with fewer cells

Single-cell RNA sequencing, or "scRNA-seq" for short, is a technique that allows scientists to study the expression of genes in an individual cell within a mixed population – which is virtually how all cells exist in the body's tissues.

15 Feb 2022

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

14 Feb 2022

New protocol for transplanting 3D cellular structures to regenerate damaged intestinal tissue

Ulcerative colitis is an inflammatory bowel disease (IBD) that causes inflammation and ulcers (sores) in the digestive tract. Ulcerative colitis affects the innermost lining of the colon and rectum.

10 Feb 2022

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

A study published on the bioRxiv* preprint server evaluates molnupiravir against a panel of relevant VOCs using three efficacy models: primary human airway epithelium organoids, a ferret model of upper respiratory disease, and a Roborovski dwarf hamster model for severe COVID-19.

9 Feb 2022

Research lays the groundwork to better understand and treat Crohn's disease

A paper published this week in Immunity, a leading research journal highlighting discoveries in immunology by Cell Press, lays the groundwork to better understand and treat Crohn's disease, a type of Inflammatory Bowel Disease (IBD).

9 Feb 2022

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Drugs which are commonly-used as the first line of treatment for colorectal cancer cause the tumor cells to oversecrete proteins known as mucins, according to a new study published today in the journal eLife.

9 Feb 2022

Three different autism risk genes found to have similar effects on brain development

Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a similar pathology in patients has remained a mystery.

2 Feb 2022

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

A large multinational group of researchers has shown how the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained exceptional immune evasion properties but also a much lower propensity to enter cells such as those in lung alveoli, resulting in its reduced pathogenicity. Their paper is currently released as an unedited version of the manuscript prior to publication in the journal Nature.

1 Feb 2022

Researchers generate a complex kidney-like 3D tissue in the lab

A research team based in Kumamoto University (Japan) has created complex 3D kidney tissue in the lab solely from cultured mouse embryonic stem (ES) cells.

1 Feb 2022

Investigating Omicron’s fitness and replicative potential compared with earlier SARS-CoV-2 variants using organoids

This study examined the shedding, fitness, and pathogenicity of SARS-CoV-2 VOCs using human airway and alveolar organoids.

24 Jan 2022

Study suggests SARS-CoV-2 Omicron variant spike mediated immune escape and tropism shift

A new study showed that the SARS-CoV-2 Omicron spike binds to its receptor with enhanced affinity and yet evades vaccine-elicited neutralizing antibodies and that a booster mRNA vaccine broadened the neutralization of Omicron.

21 Jan 2022

Study finds Omicron infection effectively induces immunity against itself and enhances protection against other variants in vaccinated individuals

Researchers investigated the effectiveness of the SARS-CoV-2 Omicron-variant induced immunity, whether it is cross-protective against other variants, and if earlier infection with the SARS-CoV-2 Delta variant offers protection against Omicron.

20 Jan 2022

Direct effect of SARS-CoV-2 on the kidney

Researchers infected human-induced pluripotent-stem-cell (iPSC)-derived kidney organoids with SARS-CoV-2 to study the virus's direct effect on the kidney.

18 Jan 2022

Exploring the relationship between stem cells and COVID-19

Though COVID-19-related stem cell clinical research is still in its infancy, stem cell treatment offers extensive clinical application possibilities and a far-reaching relevance thanks to ongoing exploration of stem cell clinical research and data mining.

14 Jan 2022

Using lab-grown stomachs to shed light on the symptoms of COVID-19

Could lab-grown 'mini-stomachs' be used to look at COVID-19 symptoms in children? In this interview, we speak to Paolo De Coppi to find out more.

13 Jan 2022

Study opens up prospects for using virotherapy to treat central nervous system tumors

In a study conducted at the University of São Paulo's Human Genome and Stem Cell Research Center (HUG-CELL) in Brazil, serial systemic injections of zika virus into mice with brain tumors destroyed the cancer without causing neurological damage or injuring other organs, and increased the animals' survival rate.

11 Jan 2022

Organoids News and Research

Further Reading

Study uses 3D cervical organoids to show the danger of multiple infections

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

Exposure to endocrine disrupting mixtures during pregnancy impacts children's brain development

Human nose organoids provide better understanding of the first steps toward SARS-CoV-2 infection

New DisCo method allows scRNA-seq to efficiently process samples with fewer cells

Hundreds of new proteins that could play a role in cystic fibrosis discovered

New protocol for transplanting 3D cellular structures to regenerate damaged intestinal tissue

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

Research lays the groundwork to better understand and treat Crohn's disease

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Three different autism risk genes found to have similar effects on brain development

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

Researchers generate a complex kidney-like 3D tissue in the lab

Investigating Omicron’s fitness and replicative potential compared with earlier SARS-CoV-2 variants using organoids

Study suggests SARS-CoV-2 Omicron variant spike mediated immune escape and tropism shift

Study finds Omicron infection effectively induces immunity against itself and enhances protection against other variants in vaccinated individuals

Direct effect of SARS-CoV-2 on the kidney

Exploring the relationship between stem cells and COVID-19

Using lab-grown stomachs to shed light on the symptoms of COVID-19

Study opens up prospects for using virotherapy to treat central nervous system tumors

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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