Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

CU researchers awarded NEI's 3D ROC prize to accelerate development of new therapies

Natalia Vergara, PhD, assistant professor of ophthalmology at the University of Colorado School of Medicine, has been awarded a 3D ROC prize by the National Eye Institute for her research team's work to create better models to accelerate the development of new therapies for retinal diseases.

3 Feb 2021

Synthetic biology can help create complex embryo

Richard Feynman, one of the most respected physicists of the twentieth century, said "What I cannot create, I do not understand". Not surprisingly, many physicists and mathematicians have observed fundamental biological processes with the aim of precisely identifying the minimum ingredients that could generate them. One such example are the patterns of nature observed by Alan Turing.

2 Feb 2021

NEI scientists develop and test a promising gene therapy strategy for rare eye disease

Scientists at the National Eye Institute have developed a promising gene therapy strategy for a rare disease that causes severe vision loss in childhood.

28 Jan 2021

Corning to highlight newest products in 3D cell culture portfolio at SLAS2021

Corning Incorporated will highlight its latest technologies that support the advancement of 3D cell culture, automation, and drug discovery at this year's virtual Society for Laboratory Automation and Screening (SLAS) conference on Jan. 25 through 27.

22 Jan 2021

People with problems in the upper GI tract may be vulnerable to COVID-19 infection

No evidence so far indicates that food or drinks can transmit the virus that causes COVID-19, but new research at Washington University School of Medicine in St. Louis suggests that people with problems in the upper gastrointestinal (GI) tract may be vulnerable to infection after swallowing the virus.

20 Jan 2021

How does SARS-CoV-2 infect brain cells?

Researchers from the University of California San Francisco, Gladstone Institutes in the USA, and The Aga Khan University in Pakistan investigated if human neural cells can be infected by SARS-CoV-2.

20 Jan 2021

Gene editing shows potential to correct mutations causing inherited retinal degeneration

Gene editing therapies, including CRISPR-Cas systems, offer the potential to correct mutations causing inherited retinal degenerations, a leading cause of blindness.

20 Jan 2021

Novel organoid models illuminate path to cervical cancers

How do tumors develop in the cervix? Many new details are now known about this question. This is also thanks to Dr. Cindrilla Chumduri from the Biocentre at the University of Würzburg.

18 Jan 2021

Study reveals new way to target cancer’s nutritional needs

Scientists discover a way to target cancer’s nutritional needs, which could lead to a new way to treat the disease, according to a study published in Nature Communications today (Thursday).

18 Jan 2021

Study shows how neurons can become a target of SARS-CoV-2 infection

Using both mouse and human brain tissue, researchers at Yale School of Medicine have discovered that SARS-CoV-2 can directly infect the central nervous system and have begun to unravel some of the virus's effects on brain cells.

13 Jan 2021

Researchers develop a novel, patient-derived model of ulcerative colitis

As reported in Nature Communications, researchers from Cleveland Clinic's Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease.

11 Jan 2021

Researchers demonstrate SARS-CoV-2 infection in human lung bronchioalveolar tissue model

Development of an in vitro human-derived tissue model for studying virus infection and disease progression in the alveolar cells of the lungs responsible for oxygen and carbon dioxide exchange with the blood might enable the study of possible therapies for acute respiratory distress syndrome (ARDS) triggered by SARS-CoV-2.

11 Jan 2021

Synthetic lung organoids provide high-throughput platform to identify new cellular targets of SARS-CoV-2

An interesting new study published on the bioRxiv preprint server describes a new platform that allows a high-throughput workflow to generate matched human lung buds in the tens of thousands. This allows researchers to study SARS-CoV-2 infection and therapeutics in lung tissue that mirrors the key aspects of human lung development.

10 Jan 2021

Chemicals in e-cigarettes disrupt the gut barrier and trigger inflammation

Touted by makers as a "healthy" alternative to traditional nicotine cigarettes, new research indicates the chemicals found in e-cigarettes disrupt the gut barrier and trigger inflammation in the body, potentially leading to a variety of health concerns.

7 Jan 2021

Mount Sinai and Rumi Scientific join hands to initiate autism drug discovery pipeline

The Seaver Autism Center for Research and Treatment at the Icahn School of Medicine at Mount Sinai and Rumi Scientific announced today that they will team up to initiate a drug discovery pipeline for rare genetic disorders that carry a high risk of autism.

6 Jan 2021

Researchers identify the missing link between intestinal disease and brain injury in premature infants

Physicians have long known that necrotizing enterocolitis (NEC), a potentially lethal inflammatory condition that destroys a premature infant's intestinal lining, is often connected to the development of severe brain injury in those infants who survive.

6 Jan 2021

Novel device may help restore total eye function

An international consortium of researchers is developing a new method to bring eyes back to life from deceased body donors for clinical research purposes.

18 Dec 2020

New screening platform can be used to discover more effective drugs for type 1 diabetes

With nearly 2 million Americans battling type 1 diabetes, it is no surprise that clinical therapies for the disease are constantly evolving and improving.

16 Dec 2020

Scientists identify two drug candidates that counteract deficiencies caused by lack of MECP2 gene

Most autism spectrum disorders have a complex, multifactorial genetic component, making it difficult to find specific treatments. Rett syndrome is an exception.

9 Dec 2020

Synthetic biology and machine-learning can speed up maturation of lab-grown organ

Researchers at the University of Pittsburgh School of Medicine have combined synthetic biology with a machine-learning algorithm to create human liver organoids with blood- and bile-handling systems. When implanted into mice with failing livers, the lab-grown replacement livers extended life.

8 Dec 2020

Organoids News and Research

Further Reading

CU researchers awarded NEI's 3D ROC prize to accelerate development of new therapies

Synthetic biology can help create complex embryo

NEI scientists develop and test a promising gene therapy strategy for rare eye disease

Corning to highlight newest products in 3D cell culture portfolio at SLAS2021

People with problems in the upper GI tract may be vulnerable to COVID-19 infection

How does SARS-CoV-2 infect brain cells?

Gene editing shows potential to correct mutations causing inherited retinal degeneration

Novel organoid models illuminate path to cervical cancers

Study reveals new way to target cancer’s nutritional needs

Study shows how neurons can become a target of SARS-CoV-2 infection

Researchers develop a novel, patient-derived model of ulcerative colitis

Researchers demonstrate SARS-CoV-2 infection in human lung bronchioalveolar tissue model

Synthetic lung organoids provide high-throughput platform to identify new cellular targets of SARS-CoV-2

Chemicals in e-cigarettes disrupt the gut barrier and trigger inflammation

Mount Sinai and Rumi Scientific join hands to initiate autism drug discovery pipeline

Researchers identify the missing link between intestinal disease and brain injury in premature infants

Novel device may help restore total eye function

New screening platform can be used to discover more effective drugs for type 1 diabetes

Scientists identify two drug candidates that counteract deficiencies caused by lack of MECP2 gene

Synthetic biology and machine-learning can speed up maturation of lab-grown organ

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

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