Organoids News and Research

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Organoids are three-dimensional cell cultures from embryonic stem cells or induced pluripotent stem cells that model important features of whole organs.

New method maps 3D forces exerted by tiny cell clusters

A team of researchers has developed a new technique to map the three-dimensional forces that clusters of human cells exert on their surrounding environment. The method could potentially help scientists better understand how tissue forms, how wounds heal or how tumors spread.

3 Mar 2020

Researchers develop multi-organ-on-a-chip for drug toxicity screening

Researchers in the US have developed a new multi-organ-on-a-chip to test how new drugs affect the human body's vital organs.

2 Mar 2020

New genetic tool developed to label specific genes in human organoids

Researchers from the group of Hans Clevers at the Hubrecht Institute have developed a new genetic tool to label specific genes in human organoids, or mini organs.

2 Mar 2020

Cancer chemical from common gut microbe

Many common gut bacteria carry cancer-causing mutations, says a new study published in the journal Nature on the 27th February 2020.

27 Feb 2020

New understanding on how cancer cells communicate

Researchers from University College London have devised a new way by which they could decipher the language cancer cells use to communicate among themselves. They found this unique method of communication between the cancer cells in organoids or collections of cells mimicking a mini organism in the lab.

17 Feb 2020

New technique helps decipher how individual cancer cells communicate with each other

Scientists have a developed a new technique to decipher how millions of individual cells are communicating with each other in miniature tumors grown in the lab, known as organoids, according to new research published in Nature Methods today (Monday).

17 Feb 2020

New technology enables scientists to analyze behavior of cancer cells in lab-grown tumors

New technology developed at UCL is, for the first time, enabling cancer scientists to analyze the individual behavior of millions of different cells living inside lab-grown tumors - a breakthrough which could lead to new personalised cancer treatments.

17 Feb 2020

Scientists find a way to block the growth of kidney cancer

Scientists at the MDC have discovered stem cells responsible for the most common form of kidney cancer. The team of Walter Birchmeier has found a way to block the growth of these tumors in three models of the disease.

17 Feb 2020

New study describes inflammatory reaction in lab-developed human astrocytes

Astrocytes are neural cells with many important functions in the nervous system. The inflammation of these cells occurs in brain infections and neurodegenerative disorders, a process called astrogliosis.

14 Feb 2020

Metformin could help leaky gut

A team of researchers from University of California, San Diego, have successfully used gut organoids in their lab to show the effects of medications to treat conditions such as “leaky gut”. The study was titled, “The stress polarity signaling (SPS) pathway serves as a marker and a target in the leaky gut barrier: implications in aging and cancer,” and was published in the journal Life Science Alliance today.

10 Feb 2020

Researchers simulate leaky gut conditions using 3D models of human intestines

Once a vague scapegoat for a variety of ills, increasing evidence suggests a condition known as "leaky gut" -- in which microbes and other molecules seep out of the intestines -- may be more common, and more harmful, than previously thought.

10 Feb 2020

New study sheds light on human in vitro organ model research trends

Two distinct approaches are predominantly used to recapitulate physiologically relevant in vitro human organ models.

9 Feb 2020

Novel approach may offer a more effective way to eradicate colorectal cancer cells

A novel approach to reverse the progression of healthy cells to malignant ones may offer a more effective way to eradicate colorectal cancer cells with far fewer side effects, according to a team of researchers based in South Korea.

3 Feb 2020

Regenerative biology could be used to restore mucus production, shows study

Mucus is a protective, slimy secretion produced by goblet cells and which lines organs of the respiratory, digestive, and reproductive systems. Slime production is essential to health, and an imbalance can be life-threatening.

31 Jan 2020

A new study reveals the secrets of mucus production that could be applied to cancer biology

The cells that produce mucus are known to be involved in serious health conditions such as asthma, chronic obstructive pulmonary disease, and even cancer.

31 Jan 2020

New strategy using organoids to study childhood brain tumors

A new study reports the creation of in vitro models of brain tumors in children using organoids derived from stem cells, which will help to screen new drugs for efficacy and thus improve the rate of drug development. The study, titled 'Modeling medulloblastoma in vivo and with human cerebellar organoids,' is published in the journal Nature Communications.

29 Jan 2020

Researchers develop new strategy to study childhood brain tumors

Researchers are at work to find effective treatments to help young patients with brain tumors. Hundreds of brain organoids have been developed in the laboratories of the University of Trento to understand the genetic mechanisms responsible for these hard to treat diseases.

29 Jan 2020

Snake stem cells create real venom to use as medicine

Poisonous snakes kill more than 90,000 people each year across the globe, with about 1.2 million to 5.5 million snake bites occur annually. Despite the venomous bite, scientists have limited knowledge of the snake’s venom, complicating efforts to develop treatments. A new study has found that snake venom gland cells can be cultured in the lab as adult-stem-cell-based organoids, producing real venom, which can be used to develop treatments.

26 Jan 2020

Researchers grow venom-producing snake organoids in the lab

Researchers from the group of Hans Clevers at the Hubrecht Institute, in an international collaboration, have developed a method to grow snake venom gland cells as organoids.

23 Jan 2020