Osteoblast News and Research

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Scientists open door to development of new drugs to combat osteoporosis

Scientists from the University of Granada (UGR) have opened the door to the development of new drugs against osteoporosis, one of the most common chronic illnesses in the world, especially among women 65 or over.

6 Mar 2014

Finding could lead to new treatments for osteoporosis

Scientists at Washington University School of Medicine in St. Louis have discovered what appears to be a potent stimulator of new bone growth. The finding could lead to new treatments for osteoporosis and other diseases that occur when the body doesn't make enough bone.

31 Jan 2014

Mutation in bone cells may cause acute myeloid leukemia: Study

Acute myeloid leukemia is a blood cancer, but for many patients the cancer may originate from an unusual source: a mutation in their bone cells.

21 Jan 2014

Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation

Bone homeostasis requires precise balance between deposition of new bone by osteoblasts and resorption of old bone by osteoclasts. Bone diseases, including osteoporosis and rheumatoid arthritis, are the result of increased osteoclast activity and formation, which allows bone resorption to outpace deposition.

9 Dec 2013

Findings suggest new approach for treating inflammatory bone diseases and skeletal metastases

The skeleton is constantly being remodelled by the breakdown of old bone by cells called osteoclasts and the formation of new bone by cells called osteoblasts. This coordinated activity is essential for maintaining healthy bone. However, excessive osteoclast activity leads to bone destruction in skeletal diseases such as osteoporosis, rheumatoid arthritis and cancer metastases in bone. A family of signaling enzymes known as phosphatidylinositol 3-kinases control diverse cell functions but, up until now, little was known about the function of specific PI3K isoforms in osteoclasts.

5 Dec 2013

Researchers discover link between NOX4 enzyme and osteoporosis

Genkyotex, the leading developer of NOX enzyme inhibitors, announced today that a group of collaborators have discovered a link between the enzyme NOX4 and development of osteoporosis.

21 Oct 2013

Research on bone-derived hormone could lead to new treatments for memory loss, depression

Researchers from Columbia University Medical Center (CUMC) have found that the skeleton, acting through the bone-derived hormone osteocalcin, exerts a powerful influence on prenatal brain development and cognitive functions such as learning, memory, anxiety, and depression in adult mice.

27 Sep 2013

Excess fat in liver, muscle tissue and blood may increase risk of bone loss

Excess fat around the belly has recently been identified as a risk factor for bone loss. Now, a new study has determined that excess liver and muscle fat also may be detrimental to bone.

16 Jul 2013

Investigators report possible missing link necessary to prevent osteoporosis

By analyzing biopsy specimens from patients with postmenopausal osteoporosis and primary hyperparathyroidism, investigators have begun to pay increasing attention to "reversal cells," which prepare for bone formation during bone remodeling.

6 Jun 2013

Surgeons identify role of stem cells in bone regeneration process

For many patients the removal of several centimetres of bone from the lower leg following a serious injury or a tumour extraction is only the beginning of a long-lasting ordeal.

4 Apr 2013

Link between Jagged-1 protein and bone formation

Researchers from the University of Pennsylvania School of Veterinary Medicine have discovered that a protein called Jagged-1 stimulates human stem cells to differentiate into bone-producing cells.

14 Feb 2013

Complex process of bone disease evident in mastocytosis

Patients with mastocytosis show elevated bone turnover that is associated with a higher mast cell load and advanced disease relative to individuals without the condition, suggest study findings.

12 Dec 2012

New method can generate stable human mesenchymal stem cells for bone engineering

Human mesenchymal stem cells (hMSCs) can develop into bone cells and are useful for tissue engineering and regeneration. However, when grown in the laboratory they quickly lose their ability to continue dividing and they die.

5 Dec 2012

Weill Cornell Medical College researcher wins 2012 William B. Coley Award

Dr. Laurie H. Glimcher, the Stephen and Suzanne Weiss Dean of Weill Cornell Medical College and provost for medical affairs of Cornell University, is a winner of the 2012 William B. Coley Award for Distinguished Research in Basic Immunology from the Cancer Research Institute for her outstanding achievements in immunology and cancer research.

19 Oct 2012

Vitamin C actively protects against osteoporosis

Researchers at Mount Sinai School of Medicine have shown for the first time in an animal model that vitamin C actively protects against osteoporosis, a disease affecting large numbers of elderly women and men in which bones become brittle and can fracture. The findings are published in the October 8 online edition of PLoS ONE.

10 Oct 2012

Five researchers receive IOF Young Investigator Awards

Five researchers were presented with 'IOF Young Investigator Awards' at the International Osteoporosis Foundation (IOF) Regionals - 2nd Middle East & Africa Osteoporosis Meeting and the 6th Pan Arab Osteoporosis Congress PAOC'6 on September 30, 2012.

2 Oct 2012

FSH-specific polyclonal antibody might offer more effective way to prevent osteoporosis

A new study suggests that a polyclonal antibody that blocks follicle-stimulating hormone (FSH) in mice without ovaries might offer a more effective way to prevent or arrest osteoporosis than currently available treatments.

21 Aug 2012

New study sheds light on exactly how cigarette smoke causes osteoporosis

Almost 20 years after scientists first identified cigarette smoking as a risk factor for osteoporosis and bone fractures, a new study is shedding light on exactly how cigarette smoke weakens bones. The report, in ACS' Journal of Proteome Research, concludes that cigarette smoke makes people produce excessive amounts of two proteins that trigger a natural body process that breaks down bone.

28 Jul 2012

Osteoporosis and sarcopenia: researchers at UMKC receive $8.3 million to study relationship

The University of Missouri-Kansas City has received a five-year, $8.3 million grant from the National Institute on Aging, part of the National Institutes of Health, to study the relationship between osteoporosis (loss of bone density) and sarcopenia (loss of muscle mass) as people age.

16 Jul 2012

$Researchers report positive effects of ibuprofen on bone repair after fracture or surgery$

Researchers report positive effects of ibuprofen on bone repair after fracture or surgery

A study conducted at the University of Granada has demonstrated that ibuprofen -a non-steroidal anti-inflammatory drug (NSAID)- has beneficial effects on bone repair after a fracture or following bone surgery.

3 Jul 2012