Osteosarcoma News and Research

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Between two and three percent of all childhood cancers are osteosarcoma. Because osteosarcoma usually develops from osteoblasts, it most commonly affects children and young adults experiencing their adolescent growth spurt. Boys and girls have a similar incidence rate until later in their adolescence, when boys are more commonly affected. While most tumors occur in larger bones, such as the femur, tibia, and humerus, and in the area of the bone that has the fastest growth rate, they can occur in any bone. The most common symptom is pain, but swelling and limited movement can occur as the tumor grows.

Osteosarcoma is an orphan disease with approximately 1,200 new cases diagnosed in the United States each year. A similar incidence of the disease exists in Europe. According to the Children's Oncology Group (COG), the survival of children with osteosarcoma has remained at 60-65 percent since the mid-1980s. The standard treatment for osteosarcoma is tumor resection with combination chemotherapy before and after surgery.
Researchers discover novel protein that governs metastasis and chemoresistance in pediatric bone cancer

Researchers discover novel protein that governs metastasis and chemoresistance in pediatric bone cancer

New study shows combination therapy is effective in treating sarcoma tumors

New study shows combination therapy is effective in treating sarcoma tumors

Study identifies epigenetic changes that occur in adult stem cells to generate different body tissues

Study identifies epigenetic changes that occur in adult stem cells to generate different body tissues

Novel surgical technique removes invasive facial tumor, recreates functional lower jaw and mouth

Novel surgical technique removes invasive facial tumor, recreates functional lower jaw and mouth

Bioniche receives U.S. and Canadian approval for first of two canine oncology products

Bioniche receives U.S. and Canadian approval for first of two canine oncology products

Three outstanding young scientists named July 2012 Damon Runyon-Sohn Fellows

Three outstanding young scientists named July 2012 Damon Runyon-Sohn Fellows

Lead 8A analog can treat osteosarcoma in children

Lead 8A analog can treat osteosarcoma in children

BTG launches Voraxaze for treatment of toxic plasma methotrexate

BTG launches Voraxaze for treatment of toxic plasma methotrexate

Longer looks: Health literacy's effect on costs

Longer looks: Health literacy's effect on costs

FDA approves new supplies of drugs that are facing shortages

FDA approves new supplies of drugs that are facing shortages

Cartilage graft can stimulate bone regeneration

Cartilage graft can stimulate bone regeneration

ZIOPHARM reports promising preclinical data with palifosfamide in pediatric sarcoma model

ZIOPHARM reports promising preclinical data with palifosfamide in pediatric sarcoma model

JDR paper shows no link between fluoride bone levels and osteosarcoma

JDR paper shows no link between fluoride bone levels and osteosarcoma

Bone fluoride levels are not associated with osteosarcoma: Study

Bone fluoride levels are not associated with osteosarcoma: Study

First dog enters ADXS-HER2 dose-ranging study in canine osteosarcoma

First dog enters ADXS-HER2 dose-ranging study in canine osteosarcoma

PCIB reports main results of Amphinex Phase I/II study against multiple cancers

PCIB reports main results of Amphinex Phase I/II study against multiple cancers

Eli Lilly, Synthes collaborate to develop osteoinductive products

Eli Lilly, Synthes collaborate to develop osteoinductive products

Mount Sinai researchers identify protein signaling hyperactivity in human sarcoma cells

Mount Sinai researchers identify protein signaling hyperactivity in human sarcoma cells

Lilly's cixutumumab Phase II study results in five subtypes of sarcoma to be presented at 47th ASCO

Lilly's cixutumumab Phase II study results in five subtypes of sarcoma to be presented at 47th ASCO

Reprogrammed herpes virus can improve early cancer diagnosis

Reprogrammed herpes virus can improve early cancer diagnosis