Oxidative Stress News and Research

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Oxidative Stress is a condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma.

Body clock's could be utilized to improve current therapies to delay onset of chronic lung diseases

The body clock's natural rhythm could be utilized to improve current therapies to delay the onset of chronic lung diseases.

From The University of Manchester 18 Mar 2014

Edison Pharmaceuticals begins EPI-743 clinical trial in children with Pearson syndrome

Edison Pharmaceuticals today announced the initiation of a phase 2 study entitled "A Phase 2 Safety and Efficacy Study of EPI-743 (Vincerinone™) in Children with Pearson Syndrome." The Investigative New Drug application (IND) was approved by the Food and Drug Administration, Office of Hematology and Oncology Products.

17 Mar 2014

FDA grants Fast Track designation to Edison’s lead drug EPI-743

Edison Pharmaceuticals today announced that the United States Food and Drug Administration granted Fast Track designation to EPI-743, the company's lead drug, for the treatment of Friedreich's ataxia. EPI-743 is being developed for pediatric and adult mitochondrial disease, including Friedreich's ataxia.

17 Mar 2014

Study provides insight into the mechanisms underlying diabetic peripheral neuropathy

Iron overload can lead to cytotoxicity, and it is a risk factor for diabetic peripheral neuropathy. However, the underlying mechanism remains unclear.

13 Mar 2014

Researchers examine role of alpha-synuclein in neuronal cells

Alpha-synuclein is a principal component of Lewy bodies and Lewy neurites, which are pathologic hall-marks of Parkinson's disease. Alpha-synuclein is generally considered to play a role in synaptic activity, although its function remains largely unknown.

13 Mar 2014

Gene linked with breast cancer susceptibility plays critical role in obesity and diabetes

The gene known to be associated with breast cancer susceptibility, BRCA 1, plays a critical role in the normal metabolic function of skeletal muscle, according to a new study led by University of Maryland School of Public Health researchers.

13 Mar 2014

Aged mice lacking antioxidant protein Nrf2 show poor stem cell regeneration

Good news for lifelong exercisers: Along with its salutary effects on the heart, weight, and other facets of health, physical activity also helps to regenerate muscle mass, which tends to diminish as people age.

11 Mar 2014

Edison Pharmaceuticals initiates Phase 2B/3 study of EPI-743 in children with Leigh syndrome

Edison Pharmaceuticals today announced the initiation of a phase 2B/3 study entitled, "A Phase 2B/3 Open-label Study of EPI-743 in Children with Leigh Syndrome" to be conducted in conjunction with Dainippon Sumitomo Pharma Co, Ltd.

10 Mar 2014

Research reveals 2 key mechanisms of oxidative stress regulation

Regulation of oxidative stress is critical to cell survival. New preclinical research from Roswell Park Cancer Institute (RPCI) has revealed two key mechanisms by which oxidative stress is regulated in normal and cancerous cells.

7 Mar 2014

New research uncovers abnormal molecular signaling pathways for kidney failure

Prevention and reversal of chronic kidney disease is an urgent public health need. The disease affects 1 in 10 Americans, is debilitating and deadly, and existing drugs, at best, offer only mild delay in progression to end-stage kidney failure.

4 Mar 2014

Study raises concerns about use of acetaminophen during pregnancy

Acetaminophen, found in over-the-counter products such as Excedrin and Tylenol, provides many people with relief from headaches and sore muscles. When used appropriately, it is considered mostly harmless. Over recent decades, the drug, which has been marketed since the 1950s, has become the medication most commonly used by pregnant women for fevers and pain.

27 Feb 2014

Antioxidant in strawberries may help control cholesterol in blood, says study

A team of volunteers ate half a kilo of strawberries a day for a month to see whether it altered their blood parameters in any way. At the end of this unusual treatment, their levels of bad cholesterol and triglycerides reduced significantly, according to the analyses conducted by Italian and Spanish scientists.

26 Feb 2014

Omega-3 supplements, sertraline could help prevent onset of depression and dementia in later life

A University of Sydney study is looking into the effectiveness of omega-3 supplements and the antidepressant, sertraline, in reducing depressive symptoms and cognitive decline in older people, in a bid to prevent the onset of depression and dementia in later life.

24 Feb 2014

Researchers examine whether spirituality has role to play in prevention of addictions

Spirituality is a central tenet of 12-step recovery programs like Alcoholics Anonymous. Its value, particularly regarding alcohol addiction, has been recognized by many health care practitioners as well.

13 Feb 2014

New research reveals potential link between alcohol consumption and breast cancer

New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease.

From The University of Manchester 12 Feb 2014

Researchers examine link between alcohol consumption and breast cancer development

New research looking at the biological process involved in breast cancer development has strengthened the argument for a potential link between alcohol consumption and the disease.

From The University of Manchester 11 Feb 2014

Study on heart attacks identifies potential new treatment target for heart disease

Research led by David Lefer, PhD, Professor and Director of the Cardiovascular Center of Excellence at LSU Health Sciences Center New Orleans School of Medicine, demonstrates for the first time cross-talk between two protective signaling molecules during a heart attack.

11 Feb 2014

Proprietary supplement improves cognitive processing speed of older adults

Declines in the underlying brain skills needed to think, remember and learn are normal in aging. In fact, this cognitive decline is a fact of life for most older Americans.

7 Feb 2014

Study finds links between degree of urbanization and prevalence of parasites in wild house finches

Humans living in densely populated urban areas have a profound impact not only on their physical environment, but also on the health and fitness of native wildlife. For the first time, scientists have found a direct link between the degree of urbanization and the prevalence and severity of two distinct parasites in wild house finches.

6 Feb 2014

Edison's vatiquinone receives Orphan Status for treatment of Friedreich's ataxia

Edison Pharmaceuticals today announced that the US Food and Drug Administration has granted Orphan Status to vatiquinone for the treatment of Friedreich's ataxia.

4 Feb 2014

Oxidative Stress News and Research

Further Reading

Body clock's could be utilized to improve current therapies to delay onset of chronic lung diseases

Edison Pharmaceuticals begins EPI-743 clinical trial in children with Pearson syndrome

FDA grants Fast Track designation to Edison’s lead drug EPI-743

Study provides insight into the mechanisms underlying diabetic peripheral neuropathy

Researchers examine role of alpha-synuclein in neuronal cells

Gene linked with breast cancer susceptibility plays critical role in obesity and diabetes

Aged mice lacking antioxidant protein Nrf2 show poor stem cell regeneration

Edison Pharmaceuticals initiates Phase 2B/3 study of EPI-743 in children with Leigh syndrome

Research reveals 2 key mechanisms of oxidative stress regulation

New research uncovers abnormal molecular signaling pathways for kidney failure

Study raises concerns about use of acetaminophen during pregnancy

Antioxidant in strawberries may help control cholesterol in blood, says study

Omega-3 supplements, sertraline could help prevent onset of depression and dementia in later life

Researchers examine whether spirituality has role to play in prevention of addictions

New research reveals potential link between alcohol consumption and breast cancer

Researchers examine link between alcohol consumption and breast cancer development

Study on heart attacks identifies potential new treatment target for heart disease

Proprietary supplement improves cognitive processing speed of older adults

Study finds links between degree of urbanization and prevalence of parasites in wild house finches

Edison's vatiquinone receives Orphan Status for treatment of Friedreich's ataxia

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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