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The potential of CRISPR-based diagnostic assays and treatment approaches against COVID-19

In their review paper recently published in the Indian Journal of Clinical Biochemistry, a group of authors discusses currently available and forthcoming CRISPR-based diagnostic assays, as well as the possibility of using the CRISPR/Cas system as a salient treatment or prevention strategy in the fight against coronavirus disease 2019 (COVID-19).

25 Apr 2021

Genome-wide CRISPR screening used to identify factors essential for SARS-CoV-2 infection in humans

In a methodologically trailblazing paper published in the journal Nature Genetics, a team of Belgian scientists uncovered an assembly of coronavirus host factors that may be exploited to develop drugs against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but also potentially forthcoming zoonotic coronaviruses.

14 Mar 2021

Researchers develop mutant gene-targeted immunotherapy approach to fight cancers

A novel targeted immunotherapy approach developed by researchers at the Ludwig Center, the Lustgarten Laboratory, and Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center employs new antibodies against genetically altered proteins to target cancers.

1 Mar 2021

Gene-cutting system may play second role as a genetic dimmer switch

In a series of experiments with laboratory-cultured bacteria, Johns Hopkins scientists have found evidence that there is a second role for the widely used gene-cutting system CRISPR-Cas9 -- as a genetic dimmer switch for CRISPR-Cas9 genes.

19 Jan 2021

SARS-CoV-2 infection analysis could help fight against COVID-19

Researchers in the United States has provided a detailed catalog of the interactions that occur between host cell proteins and RNA and the RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the course of infection.

7 Oct 2020

New genome-editing technologies can help understand disease-associated genetic mutations

New genome-editing technologies developed by researchers in J. Keith Joung's laboratory at the Massachusetts General Hospital (MGH) have the potential to help understand disease-associated genetic mutations that are based on C-to-G (cytosine to guanine) single base changes.

24 Jul 2020

New advance addresses a big challenge with using CRISPR in cancer patients

A mutation unique to certain cancer tumors is a potential homing beacon for safely deploying CRISPR gene editing enzymes to disarm DNA that makes cancer cells resistant to treatment, while ignoring the gene in normal cells where it's critical to healthy function, according to a new study from ChristianaCare's Gene Editing Institute in the journal Molecular Cancer Research.

2 Jun 2020

Researchers recombine entire chromosomes with CRISPR/Cas technology

The CRISPR/Cas molecular scissors work like a fine surgical instrument and can be used to modify genetic information in plants.

25 May 2020

Finding new treatments for muscular dystrophy with CRISPR-Cas9

A new study out of Boston's Children's Hospital has used the gene-editing tool CRISPR-Cas9 to explore the fatal genetic condition called facioscapulohumeral dystrophy (FSHD, one of the family of muscular dystrophies), and to test out the potential utility of various genes involved in this disorder. The research is published in the journal Science Translational Medicine.

25 Mar 2020

Researchers develop new kind of CRISPR screen technology to target RNA

CRISPR-based genetic screens have helped scientists identify genes that are key players in sickle-cell anemia, cancer immunotherapy, lung cancer metastasis, and many other diseases.

16 Mar 2020

Gene-editing is more error-prone than thought, new findings suggest

The standard gene-editing tool, CRISPR-Cas9, frequently produces a type of DNA mutation that ordinary genetic analysis misses, claims new research published in the journal Proceedings of the National Academy of Sciences.

26 Feb 2020

ERC promotes CRISPR research to better treat infections

Chase Beisel heads the "Synthetic Biology of RNA" research group at the Helmholtz Institute for RNA-based Infection Research (HIRI) in Würzburg, a branch of the Helmholtz Centre for Infection Research in Braunschweig and run in collaboration with the Julius-Maximilians-Universität in Würzburg.

10 Dec 2019

New tool can rapidly reveal unintended changes made by CRISPR-directed gene editing

Amidst rising hopes for using CRISPR gene editing tools to repair deadly mutations linked to conditions like cystic fibrosis and sickle cell disease, a new study in the Nature journal Communications Biology describes a new innovation that could accelerate this work by rapidly revealing unintended and potentially harmful changes introduced by a gene editing process.

6 Dec 2019

New point-of-care medical device rapidly and accurately detects viruses

The gene-editing tool CRISPR has been heralded as a scientific miracle destined to eradicate diseases from sickle-cell anemia to cancer, or decried as "the genetic scissors that tailor the human gene pool," an ethically risky technology driving us toward a designer babies.

11 Nov 2019

CRISPR-Cas9 protein can help increase targeting accuracy in genome editing process

A team of researchers from City University of Hong Kong and Karolinska Institutet has recently developed a new protein that can help increase the targeting accuracy in the genome editing process. It is believed that it would be useful for future gene therapies in human, which require high precision.

6 Nov 2019

Editing away cancer and HIV in China: win or lose?

Scientists in China recently edited out the CCR5 gene from a patient with HIV's stem cells, but the research has sparked ethical debate.

13 Sep 2019

Living Cells Can Record and Track Genomic Events with New “Designer Cell” Computer Technology

Published in Molecular Cell, researchers at Massachusetts Institute of Technology (MIT) have developed a new technology that uses DNA to process and store information in living cells.

23 Aug 2019

Newly discovered molecules safely halt the gene editing process

Scientists have discovered two non-toxic molecules that safely halt the CRISPR-Cas9 gene editing process.

22 May 2019

Scientists deploy CRISPR gene-editing tool to engineer multiple edits

Scientists at Christiana Care Health System's Gene Editing Institute and NovellusDx, an Israeli biotechnology company, have deployed a breakthrough CRISPR gene-editing tool to successfully engineer multiple edits simultaneously to fragments of DNA extracted from a human cell, according to a new study published today in The CRISPR Journal.

19 Apr 2019

CRISPR may restore effectiveness of chemotherapies used to treat lung cancer

The CRISPR-Cas9 gene editing system may be able to restore the effectiveness of first-line chemotherapies used to treat lung cancer by deleting or "knocking out" a gene in cancer tumors that helps the tumors develop resistance to the drugs.

18 Dec 2018