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Caspase-11 enzyme plays an important role in Legionella infection

New research shows that an enzyme that has long been considered relatively useless to the immune response instead has an important role in setting up immune cells to kill infection-causing bacteria.

13 Jun 2012

Polymorphism ’protective in pneumococcal disease’

Patients with invasive pneumococcal disease who have the FcyRIIa-R/R131 polymorphism may have better survival outcomes than those without the genotype, suggest study findings.

11 Jun 2012

HackensackUMC recognizes AcquiSci d-OSAB technology with research award

AcquiSci Inc., today announced it has received an award from the Hackensack University Medical Center to research AcquiSci's patented d-OSAB technology as a device-based approach to modulating inflammation.

11 Jun 2012

Biomedical engineers develop SMART detector for flu diagnosis

In April 2009, the world took notice as reports surfaced of a virus in Mexico that had mutated from pigs and was being passed from human to human. The H1N1 "swine flu," as the virus was named, circulated worldwide, killing more than 18,000 people, according to the World Health Organization. The Centers for Disease Control and Prevention in the United States said it was the first global pandemic in more than four decades.

11 Jun 2012

Discovery answers why mother's immune system does not reject developing fetus as foreign tissue

Researchers at NYU School of Medicine have made an important discovery that partially answers the long-standing question of why a mother's immune system does not reject a developing fetus as foreign tissue.

8 Jun 2012

Sorrento receives $300,000 STTR grant to develop novel therapeutics against Staph infections

Sorrento Therapeutics, Inc. today announced that it has received an Advanced Technology Small Business Technology Transfer Research (STTR) Fast Track grant from the National Institute of Allergy and Infectious Diseases (NIAID), a division of the National Institutes of Health, or NIH.

8 Jun 2012

WHO calls for greater vigilance on correct use of antibiotics against gonorrhoea

Millions of people with gonorrhoea may be at risk of running out of treatment options unless urgent action is taken, according to WHO. Already several countries, including Australia, France, Japan, Norway, Sweden and the United Kingdom are reporting cases of resistance to cephalosporin antibiotics - the last treatment option against gonorrhoea. Every year an estimated 106 million people are infected with gonorrhea, which is transmitted sexually.

7 Jun 2012

Ancient hepatitis B may hold clues to viral evolution, spread

The evolution of the hepatitis B virus and its possible migration have become clearer with the sequencing of the oldest sample of the virus, isolated from a mummified 16th-century Korean child, say scientists.

6 Jun 2012

Engineered proteins demonstrate flu-fighting potency

Computer-designed proteins are under construction to fight the flu. Researchers are demonstrating that proteins found in nature, but that do not normally bind the flu, can be engineered to act as broad-spectrum antiviral agents against a variety of flu virus strains, including H1N1 pandemic influenza.

2 Jun 2012

UV disinfection may reduce CDI in hospitals and LTCFs

In a recently published article, "Decontamination with Ultraviolet Radiation to Prevent Recurrent Clostridium difficile Infection in 2 Roommates in a Long-Term Care Facility" (Infection Control and Hospital Epidemiology, 05/2012), researchers shared the results of a trial that used Tru-D SmartUVC to prevent coincident recurrent CDI episodes in roommates in a Long-Term Care Facility (LTCF).

2 Jun 2012

New photoactive compound eradicates 'Iraqibacter' from wounds and skin infections

Researchers at the University of California, Santa Cruz, have developed a novel approach for eradicating drug-resistant bacteria from wounds and skin infections, using light to trigger the controlled release of nitric oxide. The UCSC team developed a photoactive compound that releases nitric oxide when exposed to light, and loaded it into a porous, biocompatible material that could be applied as a sprayable powder.

31 May 2012

Pseudomonas infection signals poor outcome for COPD patients

Patients with chronic obstructive pulmonary disease who are infected with Pseudomonas aeruginosa have a worse clinical outcome and are more likely to be hospitalized than those without the infection, states recent research.

30 May 2012

Patients with history of skin infection more likely to develop surgical site infections

Johns Hopkins scientists have engineered cells that behave like AND and OR Boolean logic gates, producing an output based on one or more unique inputs. This feat, published in the May issue of Nature Chemical Biology, could eventually help researchers create computers that use cells as tiny circuits.

30 May 2012

Neighborhood immunity has a role in determining risk of dengue infection

Researchers at the Johns Hopkins Bloomberg School of Public Health have found evidence of a role for neighborhood immunity in determining risk of dengue infection.

29 May 2012

New insight into immune-cell movement patterns

By pairing an intimate knowledge of immune-system function with a deep understanding of statistical physics, a cross-disciplinary team at the University of Pennsylvania has arrived at a surprising finding: T cells use a movement strategy to track down parasites that is similar to strategies that predators such as monkeys, sharks and blue-fin tuna use to hunt their prey.

28 May 2012

Brain cells prune circuits in the brain by eating away excess synapses

We’re born with our brains prewired, but as information comes in from our environment, this circuitry is updated. A study from Boston Children’s Hospital provides a new glimpse of how this happens: Brain cells known as microglia, tuned into the crosstalk between neurons, literally engulf unnecessary connections, known as synapses, and prune them away.

24 May 2012

COPD patients with P. aeruginosa infection more likely to have poor clinical outcomes

Patients with chronic obstructive pulmonary disease (COPD) who become infected with the bacterium Pseudomonas aerguinosa are more likely to have worse clinical outcomes and experience more hospitalizations during the course of their disease than COPD patients who are not infected, according to researchers from Buffalo, N.Y.

24 May 2012

Researcher restructures innovative virus-tracking software

A biomedical informatics researcher who tracks dangerous viruses as they spread around the globe has restructured his innovative tracking software to promote even wider use of the program around the world.

23 May 2012

Scientists decipher structure of bacterial injection needles at atomic resolution

The plague, bacterial dysentery, and cholera have one thing in common: These dangerous diseases are caused by bacteria which infect their host using a sophisticated injection apparatus. Through needle-like structures, they release molecular agents into their host cell, thereby evading the immune response.

21 May 2012

RA drug effective against Entamoeba histolytica

Research by a collaborative group of scientists from UC San Diego School of Medicine, UC San Francisco and Wake Forest School of Medicine has led to identification of an existing drug that is effective against Entamoeba histolytica. This parasite causes amebic dysentery and liver abscesses and results in the death of more than 70,000 people worldwide each year.

21 May 2012

Pathogen News and Research

Caspase-11 enzyme plays an important role in Legionella infection

Polymorphism ’protective in pneumococcal disease’

HackensackUMC recognizes AcquiSci d-OSAB technology with research award

Biomedical engineers develop SMART detector for flu diagnosis

Discovery answers why mother's immune system does not reject developing fetus as foreign tissue

Sorrento receives $300,000 STTR grant to develop novel therapeutics against Staph infections

WHO calls for greater vigilance on correct use of antibiotics against gonorrhoea

Ancient hepatitis B may hold clues to viral evolution, spread

Engineered proteins demonstrate flu-fighting potency

UV disinfection may reduce CDI in hospitals and LTCFs

New photoactive compound eradicates 'Iraqibacter' from wounds and skin infections

Pseudomonas infection signals poor outcome for COPD patients

Patients with history of skin infection more likely to develop surgical site infections

Neighborhood immunity has a role in determining risk of dengue infection

New insight into immune-cell movement patterns

Brain cells prune circuits in the brain by eating away excess synapses

COPD patients with P. aeruginosa infection more likely to have poor clinical outcomes

Researcher restructures innovative virus-tracking software

Scientists decipher structure of bacterial injection needles at atomic resolution

RA drug effective against Entamoeba histolytica

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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