Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Positive results from NanoString's second clinical study of PAM50-based breast cancer assay

NanoString Technologies, Inc., a privately held provider of life science tools for translational research and developer of molecular diagnostic products, today announced positive results from the second clinical validation study of its in vitro diagnostic breast cancer assay based on the PAM50 gene expression signature.

From NanoString Technologies 7 Dec 2012

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

Despite researchers' best efforts, no drug exists that can slow, halt or reverse the onslaught of Alzheimer's disease. A progressive and fatal neurodegenerative disorder, Alzheimer's has stolen the memories and livelihoods of millions-leaving patients and their families struggling to cope with the disease's devastating consequences. But today, scientists at the Gladstone Institutes propose a new research avenue that has the potential to change all that.

6 Dec 2012

New prenatal genetic test results in more clinically relevant information

A large, multi-center clinical trial led by researchers from Columbia University Medical Center (CUMC) shows that a new genetic test resulted in significantly more clinically relevant information than the current standard method of prenatal testing.

6 Dec 2012

Patients with obstructive sleep apnea have same early cardiovascular damage as diabetics

Patients with obstructive sleep apnea have the same early cardiovascular damage as diabetics, according to research presented at EUROECHO and other Imaging Modalities 2012.

5 Dec 2012

Study describes 68 cases of chronic traumatic encephalopathy in athletes, military veterans

A study done by investigators at the Boston University Center for the Study of Traumatic Encephalopathy (CSTE) and the Veterans Affairs Boston Healthcare System, in collaboration with the Sports Legacy Institute (SLI), describes 68 cases of chronic traumatic encephalopathy (CTE) among deceased athletes and military veterans whose brain and spinal cords were donated to the VA CSTE Brain Bank.

4 Dec 2012

Studies explore F-18-FLT PET utility in providing prognostic information for patients with gliomas

In the management of gliomas-or tumors that originate in the brain-precise assessment of tumor grade and the proliferative activity of cells plays a major role in determining the most appropriate treatment and predicting overall survival.

4 Dec 2012

Stem cells give insight into path of cytomegalovirus infection

Primitive human stem cells are resistant to human cytomegalovirus, say researchers who believe this finding could provide further insight into disease pathology.

3 Dec 2012

Topical simvastatin may be answer to nonhealing diabetic wounds

Topical simvastatin significantly accelerates wound healing in mice and may be a good treatment option for diabetic patients with nonhealing wounds, say researchers.

30 Nov 2012

Lewy pathology out of favor as Parkinson’s culprit

Neurodegeneration and cellular dysfunction may precede the appearance of Lewy bodies in the substantia nigra, shows research that challenges the role of Lewy pathology in Parkinson’s disease.

30 Nov 2012

LSUHSC's Louisiana Tumor Registry wins Data Quality Profile First Place Award from NCI

The Surveillance Epidemiology and End Results (SEER) Program of the National Institutes of Health's National Cancer Institute awarded the Louisiana Tumor Registry at the LSU Health Sciences Center New Orleans School of Public Health with a 2012 Data Quality Profile First Place Award.

30 Nov 2012

GM1 ganglioside effectively treats patients with Parkinson's disease

Treating Parkinson's disease patients with the experimental drug GM1 ganglioside improved symptoms and slowed their progression during a two and a half-year trial, Thomas Jefferson University researchers report in a new study published online November 28 in the Journal of the Neurological Sciences.

30 Nov 2012

Fn14 gene plays a role in growth and spread of non-small cell lung cancer tumors

Lung cancer researchers at St. Joseph's Hospital and Medical Center in Phoenix, Ariz., in collaboration with researchers at the Translational Genomics Research Institute and other institutions, have identified a gene that plays a role in the growth and spread of non-small cell lung cancer tumors, opening the door for potential new treatment options.

30 Nov 2012

Michigan State University, DWCHA receive teaching health center grant from HRSA

The Detroit Wayne County Health Authority (Health Authority) and Michigan State University College of Osteopathic Medicine (MSU) have been funded by the Health Resources and Services Administration (HRSA) to establish a teaching health center in Wayne County.

30 Nov 2012

Scientists define key underlying process implicated in multiple sclerosis

Scientists at the Gladstone Institutes have defined for the first time a key underlying process implicated in multiple sclerosis (MS)-a disease that causes progressive and irreversible damage to nerve cells in the brain and spinal cord. This discovery offers new hope for the millions who suffer from this debilitating disease for which there is no cure.

30 Nov 2012

Study identifies risk factors associated with co-exposure to lead, mercury and PCBs

Nearly 23 percent of American women of childbearing age met or exceeded the median blood levels for all three environmental chemical pollutants - lead, mercury, and PCBs - tracked in an analysis of data on thousands of women by Brown University researchers.

29 Nov 2012

Vermillion’s OVA1 diagnostic test effectively identifies early-stage ovarian cancer

Gynecologic Oncology, the prestigious medical journal of the Society for Gynecologic Oncology, has published the second prospective clinical study of OVA1 which demonstrated the positive performance of the multi-biomarker test in the triage of early-stage ovarian cancer.

29 Nov 2012

Cry acoustics may help identify infants at risk of autism

Autism is a poorly understood family of related conditions. People with autism generally lack normal social interaction skills and engage in a variety of unusual and often characteristic behaviors, such as repetitive movements. While there is no specific medical treatment for autism, some success has been shown with early behavioral intervention.

28 Nov 2012

REEAD technology can diagnose malaria infections with very high sensitivity

Malaria is a life-threatening disease that strikes more than 200 million people every year - mainly in Africa, Asia and Latin America. The disease is caused by the Plasmodium parasite, which is spread by infected mosquito bites. Today, malaria can be prevented and successfully treated, but more than half a million people nevertheless die every year from the disease.

28 Nov 2012

Topically applied simvastatin enhances wound recovery in diabetic mice

Delayed wound healing is a major complication of diabetes because the physiological changes in tissues and cells impair the wound healing process. This can result in additional disease outcomes such as diabetic foot ulcer, a significant cause of morbidity in the growing population of diabetic patients. A new study has found that topically applied simvastatin accelerates wound healing in diabetic mice, suggesting important implications for humans with diabetes.

28 Nov 2012

New way to protect neurons that express mutant huntingtin proteins

By using a model, researchers at the University of Montreal have identified and "switched off" a chemical chain that causes neurodegenerative diseases such as Huntington's disease, amyotrophic lateral sclerosis and dementia. The findings could one day be of particular therapeutic benefit to Huntington's disease patients. "We've identified a new way to protect neurons that express mutant huntingtin proteins," explained Dr. Alex Parker of the University of Montreal's Department of Pathology and Cell Biology and its affiliated CRCHUM Research Centre.

27 Nov 2012

Pathology News and Research

Further Reading

Positive results from NanoString's second clinical study of PAM50-based breast cancer assay

Investigators describe process by which apoE4 protein promotes development of Alzheimer's

New prenatal genetic test results in more clinically relevant information

Patients with obstructive sleep apnea have same early cardiovascular damage as diabetics

Study describes 68 cases of chronic traumatic encephalopathy in athletes, military veterans

Studies explore F-18-FLT PET utility in providing prognostic information for patients with gliomas

Stem cells give insight into path of cytomegalovirus infection

Topical simvastatin may be answer to nonhealing diabetic wounds

Lewy pathology out of favor as Parkinson’s culprit

LSUHSC's Louisiana Tumor Registry wins Data Quality Profile First Place Award from NCI

GM1 ganglioside effectively treats patients with Parkinson's disease

Fn14 gene plays a role in growth and spread of non-small cell lung cancer tumors

Michigan State University, DWCHA receive teaching health center grant from HRSA

Scientists define key underlying process implicated in multiple sclerosis

Study identifies risk factors associated with co-exposure to lead, mercury and PCBs

Vermillion’s OVA1 diagnostic test effectively identifies early-stage ovarian cancer

Cry acoustics may help identify infants at risk of autism

REEAD technology can diagnose malaria infections with very high sensitivity

Topically applied simvastatin enhances wound recovery in diabetic mice

New way to protect neurons that express mutant huntingtin proteins

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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