Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Book about triple negative breast cancer

Hope, Treatment, and Recovery by Patricia Prijatel is exactly that-an encouraging guide to surviving a disease often referred to as, "a particularly aggressive and difficult to treat form of cancer." Prijatel is a health journalist who, at the age of 60 was diagnosed with triple negative breast cancer [TNBC] a disease which disproportionately affects young women and women of African descent. No book existed on TNBC at the time of Prijatel's diagnosis.

19 Oct 2012

Study explains link between infertility and hyperprolactinaemia

One of the most frequent is the existence of tumours that induce an over-secretion of this hormone. These women present with chronic infertility due to anovulation. Thanks to the work of the Inserm researchers from unit 693 "Steroid receptors: endocrinian and metabolic physiopathology", the intimate mechanism of the hyperprolactinaemia alterations affecting reproduction in mice has been discovered.

19 Oct 2012

Stat5 protein could serve as biomarker to help guide prostate cancer treatment

Men who had high levels of the activated Stat5 protein in their prostate cancer after a radical prostatectomy were more likely to have a recurrence or die from the disease compared to men who had little to no presence of the growth protein, according to a recent study published in Human Pathology by Jefferson's Kimmel Cancer Center researchers.

17 Oct 2012

Recurrent patterns of genomic imbalances determine evolution of invasive breast cancer

Ductal carcinoma in situ (DCIS) is considered a precursor lesion for invasive breast cancer if untreated, and is found in approximately 45% of patients with invasive ductal carcinoma (IDC). Patients with DCIS only (not accompanied by invasive disease) have a 5-year-survival of nearly 100%, compared to 89% for all stages of invasive breast cancer (24% for patients with distant metastasis).

17 Oct 2012

Brachyury variation may increase risk of chordoma

A genetic variation possessed by 40% of the population is associated with a five-fold increase in risk for developing chordoma, a cancer that strikes the bones of the skull and spine.

17 Oct 2012

Breast cancer… do you know who diagnoses you?

Australian women have a 1 in 9 lifetime risk of developing breast cancer and 1 in every 100 breast cancers occurs in men. In 2012, it is estimated that 14,610 women will be diagnosed with breast cancer, making it the most common cancer affecting women in Australia. However, despite this, few people realise that pathologists arguably play the most important role in the detection and treatment of breast cancer.

16 Oct 2012

Clinical prediction rules developed for chorioamnionitis in preterm babies

A clinical prediction rule composed of clinical birth variables could be used to predict histologic chorioamnionitis and histologic chorioamnionitis with fetal involvement in preterm babies, a study shows.

15 Oct 2012

FIGHT HLH Consortium receives EUR 6 million FP7 grant for testing NovImmune's NI-0501

NovImmune SA announced that the European Commission has awarded a 6 million Euros FP7 grant to the "FIGHT HLH" consortium of institutions to support clinical testing of NovImmune's anti-interferon gamma drug candidate, NI-0501.

15 Oct 2012

Regulatory B cells may provide effective treatment for severe autoimmune diseases

Reproducing a rare type of B cell in the laboratory and infusing it back into the body may provide an effective treatment for severe autoimmune diseases such as multiple sclerosis or rheumatoid arthritis, according to researchers at Duke University Medical Center.

15 Oct 2012

Comparing animal and human cancer is of mutual benefit

A diagnosis of cancer once spelled the end for our animal companions but the launch today of a specialty cancer clinic, led by one of Australia’s leading veterinary oncologists at the University of Sydney, offers new hope.

14 Oct 2012

Bidirectional communication between breast cancer cells and nearby MSCs cause metastasis

In recent years investigators have discovered that breast tumors are influenced by more than just the cancer cells within them. A variety of noncancerous cells, which in many cases constitute the majority of the tumor mass, form what is known as the "tumor microenvironment."

12 Oct 2012

Two CUMC studies provide new insights into spinal muscular atrophy

A study by scientists from the Motor Neuron Center at Columbia University Medical Center (CUMC) suggests that spinal muscular atrophy (SMA), a genetic neuromuscular disease in infants and children, results primarily from motor circuit dysfunction, not motor neuron or muscle cell dysfunction, as is commonly thought.

12 Oct 2012

USC project seeks to answer important questions about cancer

Three groups of University of Southern California (USC) researchers-representing medicine, chemistry and chemical engineering-are recipients of highly competitive grants from the National Institutes of Health's National Cancer Institute (NCI).

11 Oct 2012

Transplanted neural stem cells able to produce new myelin in children with PMD

A Phase I clinical trial led by investigators from the University of California, San Francisco and sponsored by Stem Cells Inc., showed that neural stem cells successfully engrafted into the brains of patients and appear to have produced myelin.

11 Oct 2012

Mayo Medical Laboratories launches mobile test catalog and reference apps

Mayo Medical Laboratories is introducing two comprehensive mobile applications for iPhones and iPads, allowing physicians and pathologists unparalleled access to clinical laboratory expertise from Mayo Clinic.

10 Oct 2012

Time is of the essence in depressed diabetes patients

Among patients with diabetes and comorbid depression, the time point at which they developed depression may have important implications for their clinical management, say researchers.

5 Oct 2012

GRID1 thalamo-cortical gene variations absent in schizophrenia

Genetic variation in the glutamate receptor delta 1 gene affects gray matter of the anterior thalamus and left lateral prefrontal cortex in healthy individuals but not among patients with schizophrenia, suggest findings published in the Journal of Psychiatric Research.

5 Oct 2012

New prototype mouse model duplicates the human response in rheumatoid arthritis

Researchers at Northwestern University Feinberg School of Medicine have developed the first animal model that duplicates the human response in rheumatoid arthritis (RA), an important step that may enable scientists to discover better medicines to treat the disease.

5 Oct 2012

Age impacts salivary markers of oxidative stress, oral pathology

Age has a significant impact on the variance of salivary markers of oxidative stress, and could shed light on the pathogenesis of oral diseases, report Slovakian researchers.

4 Oct 2012

Routine screening influences outcomes in prostate cancer after surgery

Men who undergo radical prostatectomy for a tumor that was detected by screening show better long-term outcomes than their peers who undergo the surgery after opportunistic diagnosis, study results show.

3 Oct 2012