Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

Scientists discover nanoparticle to deliver DNA with minimum toxic effect

In lab experiments, the researchers have found that this device, a vector, is able to deliver DNA deeply enough into a cell to allow genetic material to be activated - a critical step in gene therapy. This vector is between 2 - and 10 times more effective than other experimental materials, according to the research.

7 Jul 2010

FDA grants Angion Biomedica's BB3 therapeutic Fast Track and Orphan Drug product designations

Angion Biomedica Corp., a biopharmaceutical company dedicated to the discovery and development of novel therapeutics that enhance quality of life, eradicate disease and save lives by modulating the body's protective, reparative and regenerative systems, announced today that its lead therapeutic BB3 was accepted into the Fast Track program of the U.S. Food and Drug Administration (FDA) and has also been designated an Orphan Drug product by FDA.

7 Jul 2010

Clusterin associated with development, severity and progression of Alzheimer's disease: Report

Higher concentrations of clusterin, a protein in the blood plasma, appears to be associated with the development, severity and progression of Alzheimer's disease, according to a report in the June issue of Archives of General Psychiatry, one of the JAMA/Archives journals.

6 Jul 2010

Endo subsidiary successfully completes tender offer for HealthTronics' outstanding common stock

Endo Pharmaceuticals today announced the successful completion of the tender offer by its wholly owned subsidiary, HT Acquisition Corp., for all of the outstanding shares of common stock of HealthTronics, Inc..

3 Jul 2010

Over 28,000 patients access myMDAnderson web-based portal for personal health information in one year

Just one year after The University of Texas MD Anderson Cancer Center launched its secured, Web-based portal for personal health information, more than 28,000 patients (57 percent) who logged into myMDAnderson - a personalized, online connection to the center - have accessed their personal medical information, test results and records.

2 Jul 2010

BIDMC calls for new training program for personalized healthcare

The Department of Pathology at Beth Israel Deaconess Medical Center (BIDMC) have issued "A Call to Action" for the medical profession to catch up with the technology and business communities in the application of genomics to personalized health care.

2 Jul 2010

DNA damage caused by UVA radiation leads to melanoma

A new study by researchers at NYU School of Medicine found that UVA radiation damages the DNA in human melanocyte cells, causing mutations that can lead to melanoma. Melanocytes, which contain a substance called melanin that darkens the skin to protect it from the ultraviolet rays of the sun, are more vulnerable to UVA radiation than normal skin cells because they are unable to repair themselves as efficiently.

2 Jul 2010

New asthma therapy shows promise for patients who do not respond to steroid treatments

A new nonsteroidal, anti-inflammatory therapy made from a human protein significantly decreases disease signs of asthma in mice, opening the possibility of a new asthma therapy for patients who do not respond to current steroid treatments. Results of this therapy in an animal model were presented at The Endocrine Society's 92nd Annual Meeting in San Diego.

2 Jul 2010

AMP comments on array-based cytogenetic tests at FDA's public meeting

Today, the Association for Molecular Pathology presented comments at the US Food & Drug Administration's public meeting on array-based cytogenetic tests. The FDA convened the meeting to seek answers to more than a dozen questions they had on how to evaluate the performance, interpret results and report findings of array-based cytogenetic tests for copy number variation.

1 Jul 2010

Highly specific assay developed to detect ERG alterations in prostate cancer

Researchers at the Uniformed Services University of the Health Sciences Center for Prostate Disease Research, in collaboration with investigators at the Armed Forces Institute of Pathology and Walter Reed Army Medical Center, have developed a highly specific assay for the detection of ERG, a protein associated with tumor formations which is present in more than half of all prostate cancers.

1 Jul 2010

Community-based lymphatic filariasis education increases treatment compliance up to 90%: Study

Community-based lymphatic filariasis education in Orissa State, India, increased treatment compliance from around 50% to up to 90%, according to a study published June 29 in the open-access journal PLoS Neglected Tropical Diseases. In their study, researchers from the U.S. Centers for Disease Control and Prevention, in partnership with the Church's Auxiliary for Social Action, an India-based non-governmental organization, and IMA World Health, a US-based non-governmental organization, identified barriers to compliance with India's MDA program for LF, and suggest that timely educational and lymphedema management programs can reverse this trend.

1 Jul 2010

BioImagene, KUMC partner to develop Companion Algorithms for digital pathology

BioImagene, Inc., the leading provider of innovative digital pathology solutions, announced a collaboration with the University of Kansas Medical Center (KUMC) Department of Pathology & Laboratory Medicine to develop Companion Algorithms™ for next generation companion diagnostics for digital pathology.

1 Jul 2010

Collaborative project to consider new hypotheses for causation of subdural hematomas in SBS

New research led by the East Midlands Forensic Pathology Unit at the University of Leicester will consider new theories as to the cause of subdural hematomas in infants. Support for the research has been provided by the NPIA, and the project is multi-disciplinary and collaborative.

1 Jul 2010

Evotec commences EVT 101 proof-of-concept Phase II study in treatment-resistant depression

Evotec AG today announced the start of the proof-of-concept Phase II study in treatment-resistant depression with its NR2B subtype selective NMDA receptor antagonist EVT 101. This clinical development is part of an alliance between Evotec and Roche.

1 Jul 2010

AMP commends Advisory Committee for addressing genetic education, training needs

The Association for Molecular Pathology (AMP) commends the Secretary's Advisory Committee for recognizing the importance of professional and public education and training in genetics and addressing the needs in this area. AMP offers a number of continuing education programs for health professionals in genetics and genomics, including the AMP annual scientific meeting, outreach courses to health professionals, a review course in molecular genetic pathology, and online webinars geared to health professionals.

30 Jun 2010

Signature Dx obtains worldwide license to Affymetrix microarray technology for development of CRC tests

Affymetrix, Inc. and Signature Diagnostics AG today announced that they have signed a Powered by Affymetrix™ (PbA) agreement. Under the agreement, Signature Dx obtains a worldwide license to use Affymetrix® microarray technology to develop and commercialize diagnostic and prognostic colorectal cancer (CRC) tests.

29 Jun 2010

Study implicates cytokine molecule IL-17 in low back pain associated with herniated discs

An immune cell known to cause chronic inflammation in autoimmune disorders has been identified as a possible culprit in low back pain associated with herniated discs, according to doctors at Duke University Medical Center.

29 Jun 2010

Quark reports results from QPI-1007 siRNA drug study in rat ocular hypertension model of glaucoma

Quark Pharmaceuticals, Inc., a world leader in the discovery and development of RNAi-based therapeutics, today announced results from a second study of QPI-1007, a neuroprotective siRNA drug, in rat ocular hypertension model of glaucoma, conducted by Prof. Adriana Di Polo of the Department of Pathology and Cell Biology, Universite de Montreal.

29 Jun 2010

Scientists discover new mechanism of H5N1 circulation and transmission in nature

A team of scientists, led by Mauro Delogu, virologist from the Veterinary Faculty of the Bologna University and researchers from the Istituto Superiore di Sanit-, Istituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia and St. Jude Children's Research Hospital (Memphis, Tennessee) have discovered a new way of avian influenza transmission.

29 Jun 2010

New research project to develop reliable and cost-effective virtual autopsies

A new research project at the University of Leicester is set to play a vital role in continuing research into viable alternatives to invasive autopsies, which many families find to be unpleasant.

29 Jun 2010

Pathology News and Research

Further Reading

Scientists discover nanoparticle to deliver DNA with minimum toxic effect

FDA grants Angion Biomedica's BB3 therapeutic Fast Track and Orphan Drug product designations

Clusterin associated with development, severity and progression of Alzheimer's disease: Report

Endo subsidiary successfully completes tender offer for HealthTronics' outstanding common stock

Over 28,000 patients access myMDAnderson web-based portal for personal health information in one year

BIDMC calls for new training program for personalized healthcare

DNA damage caused by UVA radiation leads to melanoma

New asthma therapy shows promise for patients who do not respond to steroid treatments

AMP comments on array-based cytogenetic tests at FDA's public meeting

Highly specific assay developed to detect ERG alterations in prostate cancer

Community-based lymphatic filariasis education increases treatment compliance up to 90%: Study

BioImagene, KUMC partner to develop Companion Algorithms for digital pathology

Collaborative project to consider new hypotheses for causation of subdural hematomas in SBS

Evotec commences EVT 101 proof-of-concept Phase II study in treatment-resistant depression

AMP commends Advisory Committee for addressing genetic education, training needs

Signature Dx obtains worldwide license to Affymetrix microarray technology for development of CRC tests

Study implicates cytokine molecule IL-17 in low back pain associated with herniated discs

Quark reports results from QPI-1007 siRNA drug study in rat ocular hypertension model of glaucoma

Scientists discover new mechanism of H5N1 circulation and transmission in nature

New research project to develop reliable and cost-effective virtual autopsies

Expanding research and clinical options for children with cancer

Examining how pain could play a direct protective role in the gut

From Puberty to Menopause: Clue’s CEO, Audrey Tsang on the Power of Femtech

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