Pathophysiology News and Research

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Research advances understanding of neuroimmune mechanisms in ASD

In the Biological Psychiatry special issue "Neuroimmune Mechanisms in Autism Spectrum Disorder", guest editor Professor Kimberley McAllister of the University of California, Davis, presents five reviews and three original research articles highlighting advances that are transforming the field of autism spectrum disorder (ASD) research.

23 Feb 2017

Researchers identify genetic cause of novel myoclonic epilepsy in dogs

Researh groups from the University of Helsinki, the LMU Munich and the University of Guelph have described in collaboration a novel myoclonic epilepsy in dogs and identified its genetic cause.

21 Feb 2017

Researchers provide new data and prospects for links between gut microbiota and depression

An international group of researchers headed by André Carvalho has published in Psychotherapy and Psychosomatic a paper that provides new data and prospects for the links between the intestinal flora and several disorders, notably depression.

16 Feb 2017

Japanese scientists discover new potential treatment for septic shock

Sepsis is a life-threatening condition due to excessive immune responses to infection that damages the patient's own tissues and organs.

9 Feb 2017

Old tuberculosis drug improves impaired social behavior in autism mouse model

Reducing the function of the autism-associated gene Pcdh10 leads to impairments in social behavior, according to a study published in Biological Psychiatry.

26 Jan 2017

Researchers identify novel risk genes linked to bipolar disorder

Bipolar disorder (BD), characterized by mood swings between positive manic/hypomanic and negative/depressive states, is a common psychiatric disorder with a lifetime prevalence of ~1%.

26 Jan 2017

Scientists find altered blood-brain barrier and increased intestinal permeability in people with ASD

Autism spectrum disorder (ASD) has the dubious distinction of being the fastest-growing developmental disability in the U.S., according to the Centers for Disease Control and Prevention.

19 Jan 2017

Impact of IBS on patients

The report reveals a quite alarming situation about the economic impact of IBS on healthcare system, society and patients themselves. In particular, it disclosed that there are a lot of hidden costs related to the utilization of healthcare resources by means of patients, frequently not recognized as IBS...

16 Jan 2017

ATA releases new guidelines for diagnosis, treatment of thyroid disease during pregnancy and postpartum

New evidence-based recommendations from the American Thyroid Association provide guidance to clinicians in diagnosing and managing thyroid disease during pregnancy and the postpartum period.

6 Jan 2017

Stuttering linked to reductions in blood flow in the brain area that controls speech production

A study led by researchers at Children's Hospital Los Angeles demonstrates what lead investigator Bradley Peterson, MD, calls "a critical mass of evidence" of a common underlying lifelong vulnerability in both children and adults who stutter.

4 Jan 2017

Tau biomarker could lead to early identification of Alzheimer's disease pathology

A discovery of high relevance in medical research will be published in Volume 55, number 4 of December 2016 of the prestigious "Journal of Alzheimer's Disease (JAD)", entitled "Tau Platelets Correlate with Regional Brain Atrophy in Patients with Alzheimer's Disease".

22 Dec 2016

New study suggests how risk gene linked to ADHD may work

Genetics play a strong part in the development of attention-deficit/hyperactivity disorder (ADHD), but the path from a gene to risk for the disorder has remained a black box to researchers.

7 Dec 2016

New study shows link between metabolic syndrome and cognitive abilities in U.S. adolescents

A new study of U.S. adolescents shows an association between metabolic syndrome and impairments in reading, attention, and working memory.

30 Nov 2016

Enzyme research provides new insights into pathophysiology of depression

Despite the fact that more than four percent of the world's population suffer from depression, and even though approximately 1,500 individuals commit suicide each year in Sweden, the understanding of the pathophysiology of depression remains unclear and only a few new discoveries of mechanisms behind it have been made in recent years.

29 Nov 2016

ADD Program receives $19.5 million NIH contract to test drugs for treating epilepsy

The University of Utah College of Pharmacy's Anticonvulsant Drug Development Program has been awarded a five-year $19.5 million contract renewal with the National Institutes of Health to test drugs to treat epilepsy, and the major focus of the project is to address needs that affect millions of people worldwide -identify novel investigational compounds to prevent the development of epilepsy or to treat refractory, or drug-resistant, epilepsy.

23 Nov 2016

New method to generate kidney organoids from patient cells can help study human kidney diseases

A new method to create kidney organoids from patient cells may provide insights into how kidney diseases arise and how they should be treated.

18 Nov 2016

Single exposure to stress may cause long-term functional and structural consequences in the brain

One day a person experiences deep stress caused by a sudden happening (a traffic accident, a natural catastrophe, an episode of violence). Later on this person could develop a serious neuropsychiatric disorder that may last for years, post-traumatic stress disorder (PTSD).

16 Nov 2016

New bioinformatic framework identifies protein that plays key role in diabetic kidney disease

A new bioinformatic framework developed by researchers at University of California San Diego School of Medicine has identified key proteins significantly altered at the gene-expression level in biopsied tissue from patients with diabetic kidney disease, a result that may reveal new therapeutic targets.

16 Nov 2016

Identifying foods that trigger IBS: an interview with Dr Bill Chey

IBS is a common medical condition which is diagnosed in the presence of characteristic gastrointestinal symptoms including recurring bouts of abdominal pain and diarrhea and/or constipation. IBS patients also commonly report bloating and abdominal distension or swelling.

15 Nov 2016

Study explores biological marker to predict individual response to drug treatment for combat PTSD

Treatment with the drug prazosin effectively reduces symptoms of posttraumatic stress disorder (PTSD) for many people, but about one third of patients don't respond to the treatment at all.

5 Nov 2016